Navigation Links
Researchers identify main genes responsible for asthma attacks in children
Date:11/17/2013

An international team spearheaded by researchers from the University of Copenhagen has identified the genes that put some children at particularly high risk of serious asthma attacks, including one not previously suspected of being implicated in the disease. In the long term, these new findings are expected to help improve treatment options for the disease, which represents a high cost for families and society alike.

Asthma is the most frequent chronic disease in children and also the most common reason for Danish children being admitted to hospital. Very young children are at especially high risk of severe asthma attacks requiring hospitalisation. This is hard on both child and family and severely strains society's resources. Nonetheless, doctors still have insufficient knowledge about asthma attacks in infants, making the condition difficult to prevent and treat. It is hoped that the recent research findings will help change this. An international team spearheaded by researchers from the University of Copenhagen have now identified the genes that put some children at risk of experiencing severe asthma attacks. The results have been published in the prestigious scientific journal Nature Genetics.

"Our results show that asthma attacks requiring young children to be hospitalised are usually genetically related. Genes play a far greater role in children with asthma than in adults. By screening children's DNA we've discovered that a gene called CDHR3, which was previously unassociated with the disease, plays a key role for the development of asthma, particularly in the very early years of life. Our study supports the theory that asthma is not just a single disease, but a complex of several sub-types that should be genetically mapped and understood individually if we are to prevent and treat the disease properly in future," says Klaus Bnnelykke, MD, PhD. He works for the Copenhagen Studies of Asthma in Childhood (COPSAC), the Danish Pediatric Asthma Center, Copenhagen University Hospital.

The researchers have studied the genes of 1,200 young children aged between two and six who had been hospitalised several times because of severe asthma attacks, and compared them with 2,500 healthy people.

Individualised treatment

Today doctors use the same medication to treat different types and degrees of asthma, but the researchers hope that improved understanding of the sub-types of the disease will pave the way for individualised treatment in future.

"Although good asthma medication is available today, it doesn't work for everyone. Specifically we need effective medicine to prevent very young children from being hospitalised and to treat them once they have been admitted. That's why we started looking at this particular group. Because asthma symptoms are fairly similar in all children, doctors tend to approach the condition in the same way. However, in reality asthma has many different underlying mechanisms, which need to be individually mapped," says Klaus Bnnelykke. He explains that to date researchers have focused on various theories about asthma attack prevention in young children, for example, recommending breastfeeding and avoiding pets and dust mites in the home.

"We know that children exposed to smoking have a higher risk of asthma attacks, but beyond that, none of our advice has really helped, and we won't make any progress until we understand the individual sub-types of asthma and their underlying mechanisms. In this respect knowledge about risk genes is an important step in the right direction," he points out.

Large volume of data

The study was headed by Klaus Bnnelykke and his colleague Hans Bisgaard, Professor of Paediatrics at the University of Copenhagen, chief physician of the Copenhagen Studies of Asthma in Childhood (COPSAC) and head of the Danish Paediatric Asthma Center. The study was conducted in collaboration with various research groups, including the Danish Centre for Neonatal Screening, Statens Serum Institut, Copenhagen, and Center for Biological Sequence Analysis (CBS), Technical University of Denmark,, as well as research teams in the USA, Spain, the UK and the Netherlands.

The study was based on examinations of 1,200 Danish children hospitalised for asthma and 2,500 healthy individuals. Two- to six-year-old children who had been hospitalised at least twice were identified in the hospital records. Their DNA was then screened for risk genes, and subsequent studies of children from Denmark and abroad confirmed the discovery of a new risk gene (CDHR3).


'/>"/>

Contact: Klaus Bønnelykke
kb@copsac.com
45-31-90-32-59
University of Copenhagen
Source:Eurekalert

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
3. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
4. UNH researchers find African farmers need better climate change data to improve farming practices
5. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
6. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
7. Researchers print live cells with a standard inkjet printer
8. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
9. Researchers reveal how a single gene mutation leads to uncontrolled obesity
10. Researchers discover novel therapy for Crohns disease
11. New paper by Notre Dame researchers describes method for cleaning up nuclear waste
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/11/2016)... , Feb. 11, 2016  According to new research ... mainstream. More than 200 fingerprint, iris, and eye-vein ... under 70 brand names. This includes market leaders ... ZTE. Acuity projects that 600 million biometric smartphones ... global installed base. Maxine Most , ...
(Date:2/11/2016)...  Vigilant Solutions announces today that its license plate recognition ... Lee,s Summit Police Department to improve ... of a homicide suspect. Kansas City ... square miles and is home to roughly 100,000 residents. ... mobile license plate reader system and also leverages Vigilant,s network ...
(Date:2/10/2016)... India , February 10, 2016 /PRNewswire/ ... --> According to 2016 iris recognition ... identification iris recognition is more widely accepted ... available with both fingerprint and iris recognition ... the user to avoid purchasing two individual ...
Breaking Biology News(10 mins):
(Date:2/12/2016)... ... , ... Global Stem Cells Group has announced an inaugural conference ... Quito, Ecuador, Feb. 24-March 6, 2016. The new facility will provide advanced protocols and ... Stem Cells Group CEO Benito Novas will host the event, which will begin with ...
(Date:2/12/2016)... , Feb. 12, 2016 Biocom, the association representing ... took a group of San Diego ... of its 2016 Precision Medicine Advocacy Fly-In. Biocom Fly-In participants ... and Drug Administration (FDA), the Centers for Medicare and Medicaid ... as San Diego U.S. Representatives Susan Davis and ...
(Date:2/12/2016)... ... February 12, 2016 , ... The Pittcon 2016 Exposition, which ... will include 848 exhibitors (count as of February 9) of which 119 are ... used by the scientific community in industrial, academic, and government labs. The Exposition ...
(Date:2/12/2016)... , Feb. 12, 2016  BD (Becton, Dickinson and ... technology company, today announced the launch of the BD ... and Technology (AGBT) Meeting. --> ... genomic research by providing cost effective NGS library preparation ... a high-throughput, fully integrated, next generation sequencing (NGS) library ...
Breaking Biology Technology: