Navigation Links
Researchers identify link between colon cancer and metabolism
Date:5/13/2014

HEIDELBERG, 13 May 2014 More than 60 years ago Otto Warburg recognized that cancer cells differ from normal cells in the metabolic pathway they use for the oxidation of sugar. Rather than the typical series of oxidative steps that take place in the citric acid cycle, cancer cells metabolize sugar via the glycolytic pathway irrespective of whether oxygen is present or not. In The EMBO Journal, researchers in the United States report that the reason for this difference in colon cancer is changes in the Wnt signaling pathway, an essential communication pathway operating in these tumours.

"Cancer cells have different metabolic demands than normal cells," remarked Marian Waterman, Professor at the University of California, Irvine and the lead author of the study. "However, until now the molecular evidence for how this metabolic reprogramming takes place in cancers of the colon has not been very well defined. Our results show that Wnt signaling plays an important role in establishing aerobic glycolysis as the predominant sugar-metabolizing pathway to support colon cancer. We have also been able to identify one of the key molecular targets for the Wnt signal in cancer cells."

Wnt signaling has been implicated for some time in the development of many cancers, including colon cancer. However, these effects have been attributed to its action on the cell cycle. The researchers decided to investigate if Wnt had another role in cancer, specifically on metabolism, due to their observations of changes to the genes of metabolic enzymes in microarray experiments for colon cancer cells.

Biochemical assays and advanced imaging techniques in live cells revealed that blocking the activity of Wnt reduced glycolysis, promoted a shift to sugar metabolism by the citric acid cycle, and reduced tumour growth. The researchers also identified the enzyme pyruvate dehydrogenase kinase 1 as one of the targets for Wnt activity related to its effects on metabolism.

"In addition to reducing the size of tumours, blocking Wnt in the colon cancer cells reduced the number of blood vessels feeding the tumour. These effects could be reversed by restoring the activity of glycolysis-promoting pyruvate dehydrogenase kinase 1 in the cancer cells," said Waterman. "Our findings illustrate that glycolysis in the cancer cells promotes blood vessel development in the nearby environment for glucose delivery to the growing tumour."

The findings of the study have implications for the development of cancer therapies targeting the Wnt pathway. The choice of system or assay used to study the effects of Wnt inhibitors can make a big difference to drug testing. "Just because a Wnt inhibitor or potential drug candidate shows no effect on cell division in one molecular test does not mean that it might not have beneficial effects for cancer treatment due to its impact on metabolism in another test," said Waterman.

"Although more work is needed to define the complete effects of Wnt signaling on metabolism, it appears that this mechanism can be added to the growing list of signal transduction pathways that directly contribute to the regulation of cellular metabolism," said Craig Thompson, professor at the Memorial Sloan Kettering Cancer Center in the United States who is not an author of the paper.


'/>"/>

Contact: Barry Whyte
barry.whyte@embo.org
European Molecular Biology Organization
Source:Eurekalert

Related biology news :

1. Researchers find a new gene expression mechanism of PRRS virus
2. Researchers find new molecule to treat asthma
3. JAX researchers identify potential therapeutic target for wound-healing and cancer
4. Henry Ford researchers identify genetic factors that may aid survival from brain cancer
5. Oregon researchers capture handoff of tracked object between brain hemispheres
6. Homemade stink bug traps squash store-bought models, Virginia Tech researchers find
7. Ban cigarette filters to save the environment, suggest researchers
8. University of Toronto researchers find seeing Jesus in Toast phenomenon perfectly normal
9. Researchers find unique fore wing folding among Sub-Saharan African Ensign wasps
10. Penn State researchers believe ants can offer human-disease insights
11. Researchers find way to decrease chemoresistance in ovarian cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/16/2017)... , Feb. 16, 2017  Genos, a community ... that it has received Laboratory Accreditation from the ... is presented to laboratories that meet stringent requirements ... scientifically rigorous processes. "Genos is committed ... laboratory practices. We,re honored to be receiving CAP ...
(Date:2/10/2017)... 10, 2017 Research and Markets ... "Personalized Medicine - Scientific and Commercial Aspects" to their ... ... is integrated with therapy for selection of treatment as well ... and prevention of disease in modern medicine. Biochip/microarray technologies and ...
(Date:2/8/2017)... Report Highlights ... The global synthetic-biology market reached nearly $3.9 billion in ... a compound annual growth rate (CAGR) of 24.0% through 2021. ... for synthetic biology. - Analyses of global market trends, with ... annual growth rates (CAGRs) through 2021. - Coverage of core ...
Breaking Biology News(10 mins):
(Date:2/23/2017)...  In Atlanta, it seems everyone has a chance to ... create an expressive and dynamic community unlike any other. The ... to it. With their newest salon in ... to carry on that tradition with a unique, fresh approach ... salon is the newest of 13 nationwide locations, each of ...
(Date:2/23/2017)... Minn. , Feb. 23, 2017  Imanis ... new product line of oncolytic vaccinia viruses for ... Corporation as part of Genelux,s proprietary, vaccinia virus-based ... are excited to enter into a partnership with ... selected oncolytic vaccinia viruses for use in research," ...
(Date:2/23/2017)... , ... February 23, 2017 ... ... announced today that in a published evaluation of multiple immunoassay-based threat detection ... Department of Energy Laboratory, PathSensors’ CANARY® biosensor threat detection technology was found ...
(Date:2/23/2017)... ... ... Today, researchers can fast-track sample collection and analysis for ... or SNPs of interest) using one, easy-to-collect saliva sample. With the addition of ... and other relevant biomarkers can be extensively studied through a non-invasive sample type. ...
Breaking Biology Technology: