Navigation Links
Researchers identify key culprit causing muscle atrophy
Date:8/13/2012

Whether you're old, have been ill, or suffered an injury, you've watched gloomily as your muscles have atrophied. The deterioration of muscleeven slight or gradualis about as common to the human condition as breathing.

Yet despite its everyday nature, scientists know little about what causes skeletal muscles to atrophy. They know proteins are responsible, but there are thousands of possible suspects, and parsing the key actors from the poseurs is tricky.

In a new paper, researchers from the University of Iowa report major progress. The team has identified a single protein, called Gadd45a, and determined that it orchestrates 40 percent of the gene activity that ultimately causes skeletal muscle to atrophy. Moreover, the researchers have learned that Gadd45a does its devilish work inside the muscle cell's nucleus, causing such a ruckus as it reprograms hundreds of genes that it changes the nucleus's shape.

"We now understand a key molecular mechanism of skeletal muscle atrophy," says Christopher Adams, associate professor of internal medicine at the UI and corresponding author on the paper published in the Journal of Biological Chemistry. "This finding could help us find a therapy for treating muscle atrophy in patients, and we now know a great place to start is by reducing Gadd45a."

Adams and his team zeroed in on Gadd45a like sleuths following a trail of clues. The researchers knew from previous work that when skeletal muscle is stressed from malnutrition, nerve damage, or inactivity, it increases its production of a protein called ATF4. That protein, in turn, initiates muscle atrophy by activating a slew of genes.

But the details remained elusive. For example, are all the genes equally important or do some play larger roles than others?

To find out, Adams and his colleagues conducted a series of experiments to discover the critical ATF4 target genes. The tests showed that ATF4 caused muscle atrophy
'/>"/>

Contact: Richard Lewis
richard-c-lewis@uiowa.edu
319-384-0012
University of Iowa
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
3. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
4. UNH researchers find African farmers need better climate change data to improve farming practices
5. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
6. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
7. Researchers print live cells with a standard inkjet printer
8. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
9. Researchers reveal how a single gene mutation leads to uncontrolled obesity
10. Researchers discover novel therapy for Crohns disease
11. New paper by Notre Dame researchers describes method for cleaning up nuclear waste
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers identify key culprit causing muscle atrophy
(Date:7/10/2014)... of the International Science and Business Belt project in ... led by professor Won Do Heo, have developed a ... remotely control specific receptors by light. They have named ... neuronal differentiation inducement. , The most significant feature of ... activate neuronal functions without the need of other substances. ...
(Date:7/10/2014)... or soap might not be ape friendly, and the situation ... in the Cell Press journal Current Biology on ... already led to the conversion of Southeast Asian forest into ... guidelines are not put in place very soon, researchers say ... Africa will be bad news for great apes there as ...
(Date:7/10/2014)... microbial megacity, teeming with life too small to be ... of bacteria can be found. Now scientists have ... own daily cyclesnot unlike the residents of a bustling ... eat at the same times., What,s more, it,s not ... energy to help them photosynthesize food from inorganic substanceshave ...
Breaking Biology News(10 mins):New optogenetic tool for controlling neuronal signalling by blue light 2Hunger for vegetable oil means trouble for Africa's great apes 2New research finds ocean's most abundant organisms have clear daily cycles 2New research finds ocean's most abundant organisms have clear daily cycles 3
... embryonic stem cell, which has the potential to become any ... of genes, proteins that bind DNA, and molecules that modify ... from MIT and the University of California at San Francisco ... cells into mature heart cells. The study, the first to ...
... A team of researchers that has been working ... within four years of a near-commercial-scale production level., The ... has received a $2 million National Science Foundation grant ... Devarenne, a Texas A&M AgriLife Research biochemist and collaborator ...
... ultrasound waves, MIT engineers have found a way to ... drug delivery more efficient. This technology could pave the ... to the researchers. "This could be used for ... systemic drugs and proteins such as insulin, as ...
Cached Biology News:Probing matters of the heart 2Probing matters of the heart 3Oil from algae closer to reality through studies by unique collaboration of scientists 2Oil from algae closer to reality through studies by unique collaboration of scientists 3Getting (drugs) under your skin 2Getting (drugs) under your skin 3
(Date:7/10/2014)... Los Angeles, CA (PRWEB) July 10, 2014 ... Analytical and Bioanalytical techniques during 18-20 August, 2014 at ... to critically review the recent developments in Analytical & ... across the globe. , Speaking on this occasion, Dr. ... that Analytica Acta conference is a remarkable one ...
(Date:7/10/2014)... 2014  Kainos Capital, a firm specializing in acquiring ... it has acquired the Slim-Fast brand from Unilever. Unilever ... of the transaction were not disclosed. Slim-Fast ... that markets ready-to-drink shakes, powders, bars and snacks to ... and in the United Kingdom ...
(Date:7/10/2014)... University of Adelaide research may help in the fight ... can detect tiny quantities of explosives with the use ... the journal Sensors and Actuators B: Chemical , ... can detect explosives in concentrations as low as 6.3 ... of only a few minutes. , "Traditionally explosives detection ...
(Date:7/10/2014)... Wash. The lithium-ion batteries that power our laptops ... longer on a single charge with the help of ... porous material to replace the graphite traditionally used in ... than 10 times the energy storage capacity of graphite. ... battery electrode was published today in Nature Communications ...
Breaking Biology Technology:A Critical Review of Analytical Techniques for Improved Living Standards 2A Critical Review of Analytical Techniques for Improved Living Standards 3A Critical Review of Analytical Techniques for Improved Living Standards 4Kainos Capital Acquires Slim-Fast From Unilever 2Detecting trace amounts of explosives with light 2Silicon sponge improves lithium-ion battery performance 2Silicon sponge improves lithium-ion battery performance 3
... security and compliance as their top issues, they dont see ... a big secret that few executives know about in most ... goes beyond knowing virus scans and firewalls. Security should be ... not a low-level function. , ,In several semesters of network ...
... and the progress of six regional firms were discussed on ... held at the Wisconsin Athletic Club. , ,Limited partners, portfolio ... in Milwaukee to hear a speech from Mark Hessen, president ... to updates from six firms that Mason Wells invests in. ...
... Care International Inc. announced on Wednesday that the U.S. Federal ... Bone Care have signed a definitive agreement for Genzyme ... at $33.00 per fully diluted share. The transaction ... at a meeting on June 30, and other customary ...
Cached Biology Technology:To find solid security candidates, look beyond tech certificates 2To find solid security candidates, look beyond tech certificates 3To find solid security candidates, look beyond tech certificates 4VC trends, company progress discussed at Mason Wells portfolio meeting 2VC trends, company progress discussed at Mason Wells portfolio meeting 3VC trends, company progress discussed at Mason Wells portfolio meeting 4
... Characteristics:, Antibody Binding: High, 400 ng ... volume) , Binding Interaction: Hydrophobic/Ionic , Performance ... (bottom): Flat , Maximum Well Volume: 360 ... tray ,Features, Special optically clear ...
...
...
... enables early selection of the best ... quantitative data for sensitivity, dynamic range, ... Furthermore quantitative antibody fingerprints can be ... your antibodies., The full-service package includes ...
Biology Products: