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Researchers identify key components linking circadian rhythms and cell division cycles
Date:1/14/2014

cle exists via serine/threonine protein kinase-29 (STK-29), the Neurospora homolog (possessing similar DNA sequence) of mammalian WEE1 kinase.

Additionally, the researchers conducted phase-shift experiments in which they transferred Neurospora to constant darkness, then administered a 90-minute pulse of white fluorescent light at indicated time points in order to induce phase-shift.

"We were able to show that when we phase-shift the circadian clock, we also observe phase-shifting of the cell cycle components," Hong says. By building on experimentally validated mathematical models from Neurospora, researchers will be able to make predictions in other Neurospora strains and mammalian cells.

As Hong puts it, "This discovery will serve as a stepping stone for further investigations to uncover conserved principles of coupled mechanisms between the cell cycle and circadian rhythms."


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Contact: Keith Herrell
keith.herrell@uc.edu
513-558-4559
University of Cincinnati Academic Health Center
Source:Eurekalert

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