Navigation Links
Researchers identify how zinc regulates a key enzyme involved in cell death
Date:4/2/2014

The molecular details of how zinc, an essential trace element of human metabolism, interacts with the enzyme caspase-3, which is central to apoptosis or cell death, have been elucidated in a new study led by researchers at Virginia Commonwealth University. The study is featured on the cover of the April issue of the journal Angewandte Chemie's International Edition.

Dysregulation of apoptosis is implicated in cancer and neurodegenerative disease such as Alzheimer's disease. Zinc is known to affect the process by inhibiting the activity of caspases, which are important drug targets for the treatment of the above conditions. The findings may help researchers design therapeutic agents that target zinc-caspase interaction to specifically control the activity of caspases, and hence, apoptosis.

"The work is unique in helping to open up a broad new area of research which we call the bioinorganic chemistry of apoptosis understanding the role of essential metal ions in one of life's fundamental processes," said corresponding author Nicholas P. Farrell, Ph.D., member of the Developmental Therapeutics program at VCU Massey Cancer Center and professor of chemistry in the VCU College of Humanities and Sciences.

"Indeed, the zinc inhibition of apoptosis in fact contrasts with the role of its closely related neighbor copper, which is understood to enhance apoptosis," he said.

In the study, Farrell and his research team, A. Gerard Daniel, Ph.D., and Erica J. Peterson, used conventional enzymology and biophysical techniques combined with state-of-the-art computational methods, to show evidence for a hitherto unrecognized interaction site with caspase-3.

According to Farrell, caspases were discovered in the mid-1990s. There are 11 caspases known humans, and seven of these are involved in cell death. The study suggests a regulatory zinc site that may be common to all caspases. Previous findings have shown other zinc binding sit
'/>"/>

Contact: Sathya Achia Abraham
sbachia@vcu.edu
804-828-1231
Virginia Commonwealth University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
3. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
4. UNH researchers find African farmers need better climate change data to improve farming practices
5. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
6. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
7. Researchers print live cells with a standard inkjet printer
8. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
9. Researchers reveal how a single gene mutation leads to uncontrolled obesity
10. Researchers discover novel therapy for Crohns disease
11. New paper by Notre Dame researchers describes method for cleaning up nuclear waste
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... natural-gas production from shale rock has increased by ... still do not fully understand the industry,s effects ... in the journal Frontiers in Ecology and ... to vastly outpace scientific examination, a team of ... including Princeton University, concluded that determining the environmental ...
(Date:7/31/2014)... by the National Science Foundation (NSF), counters a ... atmospheric warming, indicating instead that certain Arctic lakes ... the atmosphere. , The study, published this ... on thermokarst lakes, which occur as permafrost thaws ... fresh water, converting what was previously frozen land ...
(Date:7/31/2014)... has long been known that biomass burning ... as a ritual , slash-and-burn agriculture and wildfires ... health. , But until the release of a ... Engineering Professor Mark Z. Jacobson, the degree of ... Jacobson,s research, detailed in a paper published July ...
Breaking Biology News(10 mins):'Fracking' in the dark: Biological fallout of shale-gas production still largely unknown 2'Fracking' in the dark: Biological fallout of shale-gas production still largely unknown 3Certain Arctic lakes store more greenhouse gases than they release 2Stanford professor finds that wildfires and other burns play bigger role in climate change 2Stanford professor finds that wildfires and other burns play bigger role in climate change 3Stanford professor finds that wildfires and other burns play bigger role in climate change 4
... been debated in philosophical circles, and more recently, evolutionary ... of natural selection, altruism may have evolved because any ... and reproduction increases the chance of an individual,s DNA ... altruism are well known in the animal kingdom; however, ...
... -- Amphibians, for years considered a leading indicator of ... to a meta-analysis to be published in Ecology ... toxicological tests, researchers from the University of South Dakota, ... prevailing view that amphibians, with their permeable skin and ...
... international group of researchers from Carnegie Mellon University, Goettingen ... in the United Kingdom have received a Human Frontiers ... will help researchers better understand the "cellular GPS" system ... system. In the course of the development ...
Cached Biology News:Can a plant be altruistic? 2Amphibians as environmental omen disputed 2Carnegie Mellon researchers to develop probes to study cellular GPS 2
(Date:8/1/2014)... Research and Markets has announced ... (SNP) Genotyping and Analysis Market 2014-2018" report to ... Single Nucleotide Polymorphism (SNP) genotyping is the ... the genome of various species. SNPs are commonly present ... technology can analyze thousands of SNPs and has the ...
(Date:8/1/2014)... 01, 2014 BCC Research ( http://www.bccresearch.com ... DELIVERY: TECHNOLOGIES AND GLOBAL MARKETS , that the global ... to grow to nearly $38.8 billion by 2018, with ... The aptamer delivery category, the fastest moving segment of ... , The field of RNAi therapeutics has shown tremendous ...
(Date:8/1/2014)... , Aug. 1, 2014 Glencoe ... launch of "Data InPress" ( http://glencoesoftware.com/data-inpress.html ), ... integrating multidimensional image data into on-line publications.  ... and Video Injection Service. Photo ... http://photos.prnewswire.com/prnh/20140731/132409 The ...
(Date:7/31/2014)... White City, CA (PRWEB) July 31, 2014 ... well as consumers, are increasingly searching for food ... functional and nutritional benefits. The food ingredient market ... small budding players such as Vital Force Technology ... maker with more than 4,000 energetic patterns, all ...
Breaking Biology Technology:Global Single Nucleotide Polymorphism (SNP) Genotyping and Analysis Market 2014-2018 2Global Market for RNAi Drug Delivery Technologies to Reach $38.8 Billion in 2018; Aptamer Delivery Segment Surging at 58.2% CAGR 2Global Market for RNAi Drug Delivery Technologies to Reach $38.8 Billion in 2018; Aptamer Delivery Segment Surging at 58.2% CAGR 3Glencoe Software Launches Data InPress 2Glencoe Software Launches Data InPress 3Functional Ingredient Manufacturer – Vital Force Technology Infuses Raw Materials & Ingredients with Subtle Energy Formula 2
... Inc. (NASDAQ: DSCO ), a specialty biotechnology ... critical care, reported that data from a preclinical study ... recently published in the May issue of Pediatric ... improvements in lung function following administration of SURFAXIN LS ...
... Fluke Biomedical announced today their popular ... a global audience with the addition of ... http://photos.prnewswire.com/prnh/20120509/SF03362 ) (Logo: http://photos.prnewswire.com/prnh/20120130/SF43337LOGO-b ... the Fluke Biomedical Advantage training center quickly ...
... Biotech Group, a global genomic products and service ... testing for a proprietary targeted chromosomal microarray (CMA) ... microdeletions and microduplications related to a spectrum of ... Cyto OneArray ® is capable of ...
Cached Biology Technology:Newly-Published Study Compares SURFAXIN LS™ and CUROSURF® in Well-Established Model of Respiratory Distress Syndrome 2Newly-Published Study Compares SURFAXIN LS™ and CUROSURF® in Well-Established Model of Respiratory Distress Syndrome 3Newly-Published Study Compares SURFAXIN LS™ and CUROSURF® in Well-Established Model of Respiratory Distress Syndrome 4Newly-Published Study Compares SURFAXIN LS™ and CUROSURF® in Well-Established Model of Respiratory Distress Syndrome 5Fluke Biomedical training center goes global: adds multi-language support 2Phalanx Biotech Group Announces CytoOneArray®, a Targeted Chromosomal Microarray 2
A flexible 24-48 hour DNA sequencing service. Samples may be shipped in standard 1.5mL tubes. Oligo synthesis and DNA preparation available. Read lengths up to 850 Phred 20 bases. Universal primers p...
... sequencing and finishing services are tailored ... perform large-scale 5' screening or full ... considerable experience with large-scale genome projects ... an ideal cDNA outsourcing solution. In ...
... Agencourt offers quick turnaround sequencing of individual ... and high copy plasmids. Agencourt's world-class, high ... Phred20 bases per day. The key ... service are 24 48 hour sample ...
Great for biotinylating DNA/RNA probes...
Biology Products: