Navigation Links
Researchers identify how bone-marrow stem cells hold their 'breath' in low-oxygen environments
Date:9/2/2010

DALLAS Sept. 3, 2010 UT Southwestern Medical Center researchers have identified unique metabolic properties that allow a specific type of stem cell in the body to survive and replicate in low-oxygen environments.

In a study published in the September issue of the journal Cell Stem Cell, investigators found that the low-oxygen microenvironments that ordinarily deprive and starve other kinds of cells are tolerated by a type of stem cell used as the primary material for bone-marrow transplantation.

These cells, called hematopoietic stem cells, are found in marrow and can replicate quickly. Once transplanted, they eventually develop into blood and other types of cells. Their ability to self-renew before they transform into blood forms the basis of their usefulness for bone-marrow transplants.

"The cells convert glucose, or sugars, into energy rather than using oxygen to release energy," said Dr. Hesham Sadek, assistant professor of internal medicine at UT Southwestern and senior author of the study "They use glycolysis instead of mitochondrial oxidative phosphorylation to meet their energy demands."

Dr. Sadek and his team sought to understand how hematopoietic cells regulate their metabolism in spite of their inhospitable environment and found the cells expressed a certain gene in a way that enabled them to function without using oxygen.

Understanding more about the function of stem cells and their ability to self renew might lead to new avenues of encouraging the cells to grow in large numbers outside the body, Dr. Sadek said. For example, a potential bone-marrow donor's cells could be incubated and grown indefinitely, providing stem cells to be used in multiple transplant therapies.

"There have been few studies of the metabolism of stem cells, and our aim was to find out how stem cells can 'breathe' and replicate without an oxygen-rich environment crucial for other kinds of cells," Dr. Sadek said.
'/>"/>

Contact: Katherine Morales
katherine.morales@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. NC State researchers get to root of parasite genome
2. Researchers find animal with ability to survive climate change
3. Researchers find an essential gene for forming ears of corn
4. Researchers note differences between people and animals on calorie restriction
5. Researchers study acoustic communication in deep-sea fish
6. Researchers discover that growing up too fast may mean dying young in honey bees
7. Researchers study how pistachios may improve heart health
8. UI researchers find potentially toxic substance present in Chicago air
9. Researchers develop new self-training gene prediction program for fungi
10. Case Western Reserve University researchers track Chernobyl fallout
11. Childrens National researchers develop novel anti-tumor vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... University, Sweden, have explored two different ways that ... leading to the formation of oxygen molecules in ... the scientific journal Nature Communications . , ... synthetic catalysts for water oxidation, which are key ... direct storage of solar energy in fuels like ...
(Date:7/11/2014)... under the normal circumstances, astrocytes participate in ... environment, and exhibit therapeutic and repairing effects ... studies have found that nerve cells differentiated ... have reduced viability, which produces influences on ... Kailuan General Hospital, Hebei United University, China ...
(Date:7/10/2014)... and other major cities in New Mexico, nearly every ... wastewater rather than precious potable water supplies. Across the ... all golf courses receive treated effluent. Reusing the effluent ... golf courses and homeowners alike fertilize their lawns during ... nitrate. A New Mexico State University turfgrass expert has ...
Breaking Biology News(10 mins):Molecular snapshots of oxygen formation in photosynthesis 2'Tailored' water -- the latest in lawn care 2
... explain the response of patients with chronic obstructive pulmonary ... reported today (Oct. 25) at the American Society of ... used statistical methods to combine results from four individual ... moderate to severe COPD. Over 6.3 million unique ...
... cells. They,re equally indispensible in both cases. Without our bony ... cytoskeletons, our cells, which come in roughly 200 different shapes ... Using cells from the stem of a seedling as ... St. Louis seeks to understand the molecular mechanisms that organize ...
... is hosting the region,s leading scientists for discussions ... most devastating and intractable diseases of humans, including ... fungal meningitis. The Cell Biology of Eukaryotic ... campus and provides an environment for scientific discussions ...
Cached Biology News:DNA variants may influence COPD patients' response to inhaled bronchodilators 2Samurai sword protein makes strategic cuts in cell skeletons 2Samurai sword protein makes strategic cuts in cell skeletons 3Samurai sword protein makes strategic cuts in cell skeletons 4Samurai sword protein makes strategic cuts in cell skeletons 5
(Date:7/11/2014)... AZ (PRWEB) July 11, 2014 ... device company specializing in the soft tissue reconstruction ... All-Suture Anchor System for surgeries involving the shoulder ... fixation through a novel, inserter-controlled deployment method. The ... to partial deployment, anchor pull-out, or anchor displacement ...
(Date:7/10/2014)... (PRWEB) July 10, 2014 Understanding the ... channel-expressing cell lines, and the gap that currently exists ... that expand its industry-leading portfolio of validated ion channel ... ion channel-expressing cell lines, as ion channels control many ... control this activity creates the potential to treat a ...
(Date:7/10/2014)... CA (PRWEB) July 10, 2014 OMICS ... Bioanalytical techniques during 18-20 August, 2014 at Double Tree ... review the recent developments in Analytical & Bioanalytical research ... globe. , Speaking on this occasion, Dr. Srinubabu Gedela, ... Analytica Acta conference is a remarkable one in bringing ...
(Date:7/10/2014)... 2014 On July 9 Prime ... presented Russia,s first national "Industry" ... Company is developing a unique project called MabNext ... a number of innovative drugs based on monoclonal antibodies ... took place at the International Exhibition "Innoprom 2014" in ...
Breaking Biology Technology:Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 2Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 3Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 2Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 3A Critical Review of Analytical Techniques for Improved Living Standards 2A Critical Review of Analytical Techniques for Improved Living Standards 3A Critical Review of Analytical Techniques for Improved Living Standards 4Dmitry Medvedev Presented BIOCAD the First National "Industry" Award 2
... YORK, Sept. 24 Stephen Simes, chief executive,officer ... (http://www.biosantepharma.com ) will be featured in an exclusive ... at 10:30 a.m. EDT. The interview,will be posted ... on September 26. The interview will cover ...
... Kendle (Nasdaq: KNDL ), a,leading, global ... President and Chief Financial Officer Karl,"Buzz" Brenkert, III ... at the Grand Hyatt New York, Park Avenue ... Kendle,s presentation is scheduled for,Wednesday, Sept. 26 at ...
... WILMINGTON, Mass., Sept. 24 OmniSonics Medical,Technologies, Inc., ... vascular disease, today announced the appointment of J. ... Board. Mr. Cole is a founding partner ... focuses exclusively on emerging healthcare technology,companies. He brings ...
Cached Biology Technology:WallSt.net Announces Upcoming Interview with CEO of BioSante Pharmaceuticals 2Kendle to Present at the UBS Global Life Sciences Conference 2OmniSonics Appoints J. Daniel Cole Chairman of the Board 2
...
... Modification Services ,,GenScript offers many ... and antibody fragmentation. Labeling antibodies with ... visualization and quantitation of the target ... preferable to use only the antigen-binding ...
... are designed for ultra-sensitive detection of ... PVDF membranes. Since all necessary reagents ... antibodies), the WesternBreeze Kits save you ... and getting your final results. Solutions ...
Request Info...
Biology Products: