Navigation Links
Researchers identify how bone-marrow stem cells hold their 'breath' in low-oxygen environments

DALLAS Sept. 3, 2010 UT Southwestern Medical Center researchers have identified unique metabolic properties that allow a specific type of stem cell in the body to survive and replicate in low-oxygen environments.

In a study published in the September issue of the journal Cell Stem Cell, investigators found that the low-oxygen microenvironments that ordinarily deprive and starve other kinds of cells are tolerated by a type of stem cell used as the primary material for bone-marrow transplantation.

These cells, called hematopoietic stem cells, are found in marrow and can replicate quickly. Once transplanted, they eventually develop into blood and other types of cells. Their ability to self-renew before they transform into blood forms the basis of their usefulness for bone-marrow transplants.

"The cells convert glucose, or sugars, into energy rather than using oxygen to release energy," said Dr. Hesham Sadek, assistant professor of internal medicine at UT Southwestern and senior author of the study "They use glycolysis instead of mitochondrial oxidative phosphorylation to meet their energy demands."

Dr. Sadek and his team sought to understand how hematopoietic cells regulate their metabolism in spite of their inhospitable environment and found the cells expressed a certain gene in a way that enabled them to function without using oxygen.

Understanding more about the function of stem cells and their ability to self renew might lead to new avenues of encouraging the cells to grow in large numbers outside the body, Dr. Sadek said. For example, a potential bone-marrow donor's cells could be incubated and grown indefinitely, providing stem cells to be used in multiple transplant therapies.

"There have been few studies of the metabolism of stem cells, and our aim was to find out how stem cells can 'breathe' and replicate without an oxygen-rich environment crucial for other kinds of cells," Dr. Sadek said.

In addition to being successfully used for bone-marrow transplantation for years, bone-marrow cells are used in hundreds of studies for heart regeneration, he said.

"The findings of this paper highlight important characteristics of bone-marrow stem cells that make them more likely to survive in the low-oxygen environments present, for example, after a heart attack," Dr. Sadek said. "These findings may also be exploited to enrich bone-marrow stem and progenitor cells by selecting cells based on their metabolic properties."


Contact: Katherine Morales
UT Southwestern Medical Center

Related biology news :

1. NC State researchers get to root of parasite genome
2. Researchers find animal with ability to survive climate change
3. Researchers find an essential gene for forming ears of corn
4. Researchers note differences between people and animals on calorie restriction
5. Researchers study acoustic communication in deep-sea fish
6. Researchers discover that growing up too fast may mean dying young in honey bees
7. Researchers study how pistachios may improve heart health
8. UI researchers find potentially toxic substance present in Chicago air
9. Researchers develop new self-training gene prediction program for fungi
10. Case Western Reserve University researchers track Chernobyl fallout
11. Childrens National researchers develop novel anti-tumor vaccine
Post Your Comments:
(Date:11/10/2015)... YORK , Nov. 10, 2015 ... to behavioral biometrics that helps to identify and ... fraud. Signature is considered as the secure and ... the identification of a particular individual because each ... more accurate results especially when dynamic signature of ...
(Date:11/9/2015)... 9, 2015  Synaptics Inc. (NASDAQ: SYNA ), ... broader entry into the automotive market with a comprehensive ... pace of consumer electronics human interface innovation. Synaptics, industry-leading ... for the automotive industry and will be implemented in ... Europe , Japan , and ...
(Date:11/2/2015)...  SRI International has been awarded a contract of ... to the National Cancer Institute (NCI) PREVENT Cancer Program ... modern testing and support facilities, and analytical instrumentation to ... studies to evaluate potential cancer prevention drugs. ... Drug Development Program is an NCI-supported pipeline to bring ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... , ... November 24, 2015 , ... ... OrthoAccel® Technologies, Inc., on being named to Deloitte's 2015 Technology Fast 500 list ... facility, OrthoAccel manufactures AcceleDent®, a FDA-cleared, Class II medical device that speeds up ...
(Date:11/24/2015)... , Nov. 24, 2015  PDL BioPharma, Inc. (PDL) (NASDAQ: ... , the company,s president and chief executive officer, will present ... next week in New York City . ... Tuesday, December 1, 2015 at 9:30 a.m. EST. ... to the website at least 15 minutes prior to the ...
(Date:11/23/2015)... 24, 2015 Women with a certain type of ... a higher risk of lung cancer than men with similar ... at the annual meeting of the Radiological Society of ... --> --> Lung nodules are small masses ... or subsolid based on their appearance on CT. Solid nodules ...
(Date:11/23/2015)... Falls Church, VA (PRWEB) , ... November 23, 2015 , ... ... Ellen McCarthy , former Director, Plans and Programs, National Geospatial Intelligence Agency (NGA), ... comes to us with an incredibly distinguished career in the intelligence community and the ...
Breaking Biology Technology: