"From a clinical testing perspective, genes with a continuous pattern of expression can make difficult testing targets. However, the distinction between 'on' or 'off' expression for a particular bimodal gene is relatively straightforward," says Dr. Datto. "This allows clear-cut decision making boundaries and development of precise, reliable testing methods. Bimodal genes may also be candidates for testing by less quantitative methods such as immunohistochemistry."
Several of the bimodal genes that the researchers identified have known roles in tumorigenesis. "This raises the possibility that we have described molecular switch genes that will not only be relevant in the context of ovarian carcinoma, but across multiple tumor types," Dr. Datto concludes.
|Contact: David Sampson|
Elsevier Health Sciences