Navigation Links
Researchers identify gene with possible link to infertility in mice
Date:10/2/2009

RICHMOND, Va. (Oct. 2, 2009) Virginia Commonwealth University researchers have identified the role of a gene in regulating molecular signals involved with ovarian follicle development, which may one day help shed light on some of the causes of fertility issues in humans.

The steps involved with conception and pregnancy are delicate and complex particularly the process of folliculogenesis. In females, fertility is dependant on the growth of a follicle, a structure that ultimately transforms to release a mature egg. In an ordinary cycle, one follicle, known as the dominant follicle, matures to release an egg, while the rest of the eggs produced in that cycle will die. Disruption at any stage in the development of the follicle can prevent this maturation and impair fertility, as well as alter the production of hormones in the ovaries.

In the study (http://www.biolreprod.org/content/81/4/730.full.pdf+html), published online in the Oct. 1 issue of the journal Biology of Reproduction, researchers used a mouse model to examine the role of a gene known as Smad-3 in the early stages of follicular growth to better understand the molecular mechanisms that could influence fertility. Specifically, they looked at the signaling pathways involved in the follicles' response to follicle stimulating hormone, or FSH. FSH is one of the most important hormones involved in fertility and is responsible for helping a woman's body develop a mature egg.

The team, led by principal investigator Elizabeth McGee, M.D., associate professor of obstetrics and gynecology in the VCU School of Medicine, reported that female mice missing the Smad-3 gene did not experience normal ovulation and were infertile because there is a reduced ability of the follicle to respond to FSH stimulation. Further, the team concluded that Smad-3 regulates follicle growth and an important family of proteins that
'/>"/>

Contact: Sathya Achia Abraham
sbachia@vcu.edu
804-827-0890
Virginia Commonwealth University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Researchers discover new strategies for antibiotic resistance
8. Researchers find new taste in fruit flies: carbonated water
9. Binghamton University researchers investigate evolving malaria resistance
10. UIC researchers find promising new targets for antibiotics
11. Researchers develop simple method to create natural drug products
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... study (HPV-023; NCT00518336) shows the sustained efficacy, ... virus (HPV) vaccine Cervarix. Women vaccinated with ... more than nine years, and vaccine efficacy ... is the longest follow-up report for a ... for the full paper. , HPV ...
(Date:7/31/2014)... from Spain, France, and the U.S. has discovered ... oldest definitive member of the tribe Omaliini that ... and description were made possible through the use ... which allows the detailed study of otherwise invisible ... described in the journal Annals of the ...
(Date:7/31/2014)... make a rational choice to be liberal or conservative? ... a matter of genetics?, Two political scientists from the ... say that neither conscious decision-making nor parental upbringing fully ... right. , A growing body of evidence shows that ... of political differences, the researchers say in the latest ...
Breaking Biology News(10 mins):Sustained efficacy, immunogenicity, and safety for GlaxoSmithKline's HPV vaccine 2Sustained efficacy, immunogenicity, and safety for GlaxoSmithKline's HPV vaccine 3Scientists find growing consensus: Political attitudes derive from body and mind 2
... the driving force behind key discoveries in medicine and ... genome provides important markers and guidelines for medical diagnostics ... been the cost and speed of obtaining highly accurate ... the last 10 years, most current high-throughput sequencing instruments ...
... - It,s called mile-a-minute weed or "forest killer." ... spreads quickly, covering crops, smothering trees and rapidly altering ... are spearheading a four-year research project that will explore ... vulnerable to rapid environmental change, such as an invasion ...
... scab could help create new, environmentally-benign biocatalysts with the potential ... Chemists at the University of Warwick in the UK, ... have reported in the journal Nature Chemical Biology ... scabies that catalyses an aromatic nitration reaction. TxtE, ...
Cached Biology News:Columbia researchers report novel approach for single molecule electronic DNA sequencing 2Columbia researchers report novel approach for single molecule electronic DNA sequencing 3'Forest killer' plant study explores rapid environmental change factors 2'Forest killer' plant study explores rapid environmental change factors 3Remarkable enzyme points the way to reducing nitric acid use in industry 2
(Date:7/31/2014)... Today BioSpace , the leading life sciences employment and news website, ... sciences community in Illinois , Indiana ... Michigan , Minnesota , Missouri ... and Wisconsin . BioMidwest is a leader ... on BioSpace originating in this region in 2013. The life sciences sector ...
(Date:7/31/2014)... reason people over 60 are not donor candidates for ... with time, making the elderly prone to life-threatening infection ... team now has discovered a reason why. , "We ... of blood-forming cells to maintain blood production over time ... that could be restored for rejuvenation therapies," said Emmanuelle ...
(Date:7/31/2014)... even the entire body to visualize long-range connections between ... a long-time dream of biologists. A study published by ... Cell has now made that dream a ... and human tissue biopsies transparent, while keeping the cellular ... way for a better understanding of brain-body interactions, more ...
(Date:7/31/2014)... BLOOMINGTON, Ind. -- Chemists at Indiana University Bloomington ... in bricks-and-mortar fashion, a development with potential value ... as field-effect transistors and photovoltaic cells. , Their ... 3D Crystalline Solids and 2D Self-Assembled Crystals," has ... a journal of the Royal Society of Chemistry. ...
Breaking Biology Technology:Midwest Biotech Leaders Featured On BioSpace Map 2Key to aging immune system is discovered 2See-through organs and bodies will accelerate biomedical discoveries 2Chemists demonstrate 'bricks-and-mortar' assembly of new molecular structures 2Chemists demonstrate 'bricks-and-mortar' assembly of new molecular structures 3
... 2008 FINANCIAL RESULTS Confirmation of Annual and ... /PRNewswire-FirstCall/ - Angiotech Pharmaceuticals,Inc. (NASDAQ: ANPI , TSX: ... host a conference call discussing its,financial results for the ... 2008 at 11:00 AM ET (8:00 AM Pacific)., ...
... Calif., Oct. 28 Beckman,Coulter, Inc. (NYSE: ... new sole,source agreements with Adventist Health to provide ... valued at approximately $36 million over,six years. Adventist ... facilities in California, Hawaii, Oregon, and Washington., ...
... for Continued Long-Term Growth, Conference Call and Webcast to Be Held Today at 5:00 p.m. ET (22:00 CET), ... Q3 2008 ... 190.5% increase Naglazyme Net Product ... 56.3% increase Aldurazyme Net Sales by Genzyme ...
Cached Biology Technology:Notice of conference call and webcast 2Beckman Coulter Signs Agreements with Adventist Health; Broad Product Offering Enhances Delivery of Quality Patient Care 2BioMarin Announces Third Quarter 2008 Financial Results 2BioMarin Announces Third Quarter 2008 Financial Results 3BioMarin Announces Third Quarter 2008 Financial Results 4BioMarin Announces Third Quarter 2008 Financial Results 5BioMarin Announces Third Quarter 2008 Financial Results 6BioMarin Announces Third Quarter 2008 Financial Results 7BioMarin Announces Third Quarter 2008 Financial Results 8BioMarin Announces Third Quarter 2008 Financial Results 9BioMarin Announces Third Quarter 2008 Financial Results 10BioMarin Announces Third Quarter 2008 Financial Results 11BioMarin Announces Third Quarter 2008 Financial Results 12
albumin from bovine serum (BSA), Texas Red® conjugate...
Edited by P.J. Delves (1997) An up-to-date review of antibody-raising technologies, this volume provides researchers with immediate access to the protocols they require every day....
... 5 ml Dynabeads® (4.5 ... BerEP4 against the human epithelial ... molecule). Also available in ... 10e7 MNC in 1 ml ...
Superior homology search software - in all the flavours of blast, with increased sensitivity and speed. Free windows version for academic use....
Biology Products: