Navigation Links
Researchers identify cancer-causing gene in many colon cancers
Date:9/14/2008

the proliferation of colon cancer cells, the research team ran three screening tests. In the first two, they used RNA interference to shut down more than a thousand genes one by one and recorded the instances where beta-catenin activity decreased and the cells stopped growing. They then analyzed colon cancers for genes that had extra copies. When they examined where the results of the three tests overlapped, one gene stood out -- CDK8, explained Hahn, who is also an associate professor of medicine at Harvard Medical School

The protein produced from CDK8 is part of the "mediator complex," a conglomeration of proteins that serves as a bridge for compounds involved in gene transcription. "This study demonstrates that blocking CDK8 interferes with the proliferation of colon cancer cells that have high levels of the CDK8 protein and overactive beta-catenin," Hahn said. "Drugs that target CDK8 may be very useful against tumors whose growth is driven by beta-catenin."


'/>"/>

Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Researchers discover new strategies for antibiotic resistance
8. Researchers find new taste in fruit flies: carbonated water
9. Binghamton University researchers investigate evolving malaria resistance
10. UIC researchers find promising new targets for antibiotics
11. Researchers develop simple method to create natural drug products
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... ("Company") (BM&FBOVESPA: VLID3 ON), is pleased to inform its shareholders ... Washington,s Department of Licensing, in the United States, awarded ... for driver,s licenses and identification cards to its subsidiary, Valid ... start in January 2015, with enrollment and card production starting ...
(Date:1/22/2015)... , Jan. 13, 2015  Today, FreeWavz ( ... launched its crowdfunding campaign on Fundable, https://www.fundable.com/freewavz ... build of production capacity to meet customer demand. ... Photo - http://photos.prnewswire.com/prnh/20150113/168790 ...
(Date:1/22/2015)...  BellBrook Labs, a leader in high throughput screening ... a TR-FRET (time resolved Forster resonance energy transfer) ... high throughput screening assay for glycosyltransferases and other ... sensitive detection of hundreds of human and microbial ...
Breaking Biology News(10 mins):Valid USA Signs Contract For Washington Driver's License Issuance 2FreeWavz Launches on Fundable to Drive Speed-to-Market in 2015 2BellBrook Labs Launches a High Throughput Screening Assay for Glycosyltransferases with TR-FRET Readout 2
... Institute researcher Dr Matthew Call has been awarded ... Innovation (VESKI) Fellowship by the Victorian Government to ... and signalling. Dr Call,s research could signal ... treating immune diseases, using creative ,membrane mimic, technology ...
... born to mothers who are fed a diet supplemented with ... scientists at the Jean Mayer USDA Human Nutrition Research Center ... research in humans and mice suggests that B vitamins, particularly ... Using a mouse model of naturally occurring colorectal cancer, the ...
... Ariz. June 9, 2011 TGen Drug Development ... the rapid development of anti-cancer drugs and deliver them ... "The highest quality medical imaging provided by Imaging ... Dr. Stephen Gately, President of TD2, which assists drug ...
Cached Biology News:Structural biologist wins $150K for 'membrane mimic' technology 2B vitamins in mother's diet reduce colorectal cancer risk in offspring 2TGen Drug Development partners with Imaging Endpoints for comprehensive clinical trial services 2
(Date:1/22/2015)... January 22, 2015 Controlled Substance Compliance ... which helps companies check the legal requirements around using ... to China. , As their international operations expand ... adopting software solutions built as a result of the ...
(Date:1/22/2015)... , 22 de enero de 2015  El Dr. ... su llamada a nominaciones para 2015. Este prestigioso premio ... o tiene el potencial para hacer, contribuciones destacadas para ... aceptarán hasta el 15 de marzo de 2015 a ...
(Date:1/22/2015)... 2015   GenoSpace , a precision medicine software company that ... broad use of genomic, imaging and other biomedical data in ... Michelle Munson , CEO of Aspera, an IBM Company, to ... http://photos.prnewswire.com/prnh/20150122/170713 "We are pleased to ...
(Date:12/24/2014)... , Dec. 24, 2014  United Therapeutics Corporation (NASDAQ: ... (NYSE: MDT ) has submitted a pre-market ... (FDA) for the use of Medtronic,s SynchroMed ® ... catheter) for use with United Therapeutics, Remodulin ® ...
Breaking Biology Technology:Global Compliance Service for Controlled Substances to Expand to China 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4GenoSpace Expands Board with Appointment of Michelle Munson 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 3United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 4
... May 7 Dendreon Corporation (Nasdaq: DNDN ) today announced ... Bank of America and Merrill Lynch 2009 Health Care Conference, ... May 12, 2009, 9:20 a.m. ET, ... Tuesday, May 19, 2009, 4:35 p.m. ...
... Thursday, May 7, 2009 at 4:30 p.m. Eastern ... OncoGenex Pharmaceuticals, Inc. ("OncoGenex" or the "Company") (NASDAQ: ... results for the three months ended March 31, ... first quarter of 2009. , The following consolidated ...
... 6 Spectros Corporation (Portola Valley, CA) filed ... Scientific (NYSE: TMO ), alleging infringement ... 3300 product. Spectros invented and commercialized solid-state, broadband, ... and incorporated these into its flagship T-Stat product, ...
Cached Biology Technology:OncoGenex Reports First Quarter Financial Results 2OncoGenex Reports First Quarter Financial Results 3OncoGenex Reports First Quarter Financial Results 4OncoGenex Reports First Quarter Financial Results 5OncoGenex Reports First Quarter Financial Results 6Spectros Corporation Protects Its Cool White LED Spectroscopy Technology Against Alleged Infringement by Thermo Fisher Scientific 2
... produced by a patented microwave process which ... consistent, even cell attachment, increased cell growth ... growth uunder difficult conditions, including reduced serum ... a more ecominic alternative to expensive and ...
Automated Cell Culture Flask...
... Bio-Plex suspension array system, 100-240 V, uses ... up to 100 proteins and peptides in ... composed of up to 100 color-coded bead ... with a unique reactant (enzyme substrates, receptors, ...
Cell Culture Flask, 75 cm, treated polystyrene...
Biology Products: