Navigation Links
Researchers identify biomarkers of poor outcomes in preemies
Date:1/27/2011

Researchers at Cincinnati Children's Hospital Medical Center have identified biomarkers of poor outcomes in preterm infants that may help identify new approaches to prevention.

Ardythe Morrow, PhD, a researcher at the Cincinnati Children's Perinatal Institute, has identified a polymorphism a variant in a particular DNA sequence in a gene important to the development of the immune system. She found that this polymorphism raises the risk of bad outcomes in preterm infants, including death; necrotizing enterocolitis, which is the death of intestinal tissue; and gram negative sepsis, an overwhelming infection.

The study is published online in the Journal of Pediatrics.

"The secretor gene (FUT2) controls secretion of a substance known as 'H antigen' in saliva, urine, plasma, and other body fluids. Our data suggest that H antigen may be important to the health of preterm infants," says Dr. Morrow. "Research is continuing to better understand the impact of FUT2 in prematurity and should provide important insights into disease progression and infant vulnerability. We speculate these high risk infants may especially benefit from human milk oligosaccharide, a complex carboyhydrate made by enzymes of the FUT2 gene."

Dr. Morrow and her colleagues collected saliva samples from 410 infants born at or before 32 weeks gestational age. Among these infants, 26 died, 30 had necrotizing enterocolitis and 96 had confirmed sepsis.

Death occurred in 15 percent of 135 infants with low H antigen in their saliva, compared to 2 percent of 248 infants with high levels of H antigen in saliva. Low H antigen was also associated with greater odds of death due to necrotizing enterocolitis and sepsis, as well as higher odds of necrotizing enterocolitis. In addition, no secretion of H antigen predicted gram negative sepsis.

Dr. Morrow and her colleagues at Cincinnati Children's are now analyzing national data and tissue samples for a new study designed to test the role of intestinal colonization in preterm infants in relation to their FUT2 genotype. Other studies are underway to test the role of specific oligosaccharides (complex carbohydrates) in human milk in disease prevention.


'/>"/>

Contact: Jim Feuer
jim.feuer@cchmc.org
513-636-4656
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

Related biology news :

1. NC State researchers get to root of parasite genome
2. Researchers find animal with ability to survive climate change
3. Researchers find an essential gene for forming ears of corn
4. Researchers note differences between people and animals on calorie restriction
5. Researchers study acoustic communication in deep-sea fish
6. Researchers discover that growing up too fast may mean dying young in honey bees
7. Researchers study how pistachios may improve heart health
8. UI researchers find potentially toxic substance present in Chicago air
9. Researchers develop new self-training gene prediction program for fungi
10. Case Western Reserve University researchers track Chernobyl fallout
11. Childrens National researchers develop novel anti-tumor vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2017)... TEANECK, N.J. , May 16, 2017  Veratad ... leading provider of online age and identity verification solutions, ... the K(NO)W Identity Conference 2017, May 15 thru May ... Ronald Regan Building and International Trade Center. ... across the globe and in today,s quickly evolving digital ...
(Date:5/6/2017)... , May 5, 2017 RAM ... announced a new breakthrough in biometric authentication based ... quantum mechanical properties to perform biometric authentication. These new ... semiconductor material created by Ram Group and its ... entertainment, transportation, supply chains and security. Ram Group ...
(Date:4/19/2017)... 2017 The global military biometrics ... marked by the presence of several large global players. ... five major players - 3M Cogent, NEC Corporation, M2SYS ... nearly 61% of the global military biometric market in ... global military biometrics market boast global presence, which has ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... ... antibody-drug conjugate (ADC) therapeutics, today confirmed licensing rights that give it exclusive ... a technology developed in collaboration with Children’s Hospital Los Angeles (CHLA). ...
(Date:10/10/2017)... CRUZ, Calif. , Oct. 10, 2017 ... grant from the NIH to develop RealSeq®-SC (Single Cell), ... kit for profiling small RNAs (including microRNAs) from single ... Analysis Program highlights the need to accelerate development of ... "New techniques for measuring ...
(Date:10/9/2017)... ... October 09, 2017 , ... The award-winning American Farmer television series ... 2018. American Farmer airs Tuesdays at 8:30aET on RFD-TV. , With global population ... challenge of how to continue to feed a growing nation. At the same time, ...
(Date:10/7/2017)... , ... October 06, 2017 ... ... experience providing advanced instruments and applications consulting for microscopy and surface analysis, ... in application consulting, Nanoscience Analytical offers a broad range of contract analysis ...
Breaking Biology Technology: