Navigation Links
Researchers identify a new gene with a key role in obesity and diabetes
Date:1/10/2013

Scientists observed that blocking the expression of the gene TRIP-Br2 in mice protects them against obesity and insulin resistance. The study shows that the gene modulates fat storage by regulating energy expenditure and lipolysis, the process which transforms fat into lipids for the body's energy consumption. If the gene expression is blocked, the mice increase their lipolysis and their energy expenditure, thus reducing their obesity.

Obesity is the result of an alteration in the processes that regulate food absorption and energy production. This alteration tips the balance towards excessive storage of fat. According to the researchers, understanding the regulation of the factors that control the storage, mobilisation and use of excess energy in fat cells (the adipocytes) can lead to the development of therapies for obesity and its related illnesses, such as type 2 diabetes.

In the words of Cristina Mallol, a researcher at the Universitat Autnoma de Barcelona and co-author of the study: "The protection of mice with no expression of the gene TRIP-Br2, and its selective elevation in the visceral fat of humans point the way to a future gene therapy to counteract obesity, insulin resistance and excess lipids in the blood".


'/>"/>

Contact: Octavi Lpez Coronado
octavi.lopez@uab.cat
34-935-813-301
Universitat Autonoma de Barcelona
Source:Eurekalert

Page: 1

Related biology news :

1. GW researchers find variation in foot strike patterns in predominantly barefoot runners
2. Joslin researchers identify important factor in fat storage and energy metabolism
3. UCSB researchers perform pioneering research on Type 2 diabetes
4. Researchers develop tool to evaluate genome sequencing method
5. Jackson Laboratory researchers provide definitive proof for receptors role in synapse development
6. Researchers discover genetic basis for eczema, new avenue to therapies
7. Thomas Jefferson University researchers discover new pathways that drive metastatic prostate cancer
8. Carin Görings remains identified by researchers at Uppsala University
9. CNIO researchers develop new databases for understanding the human genome
10. 3 Johns Hopkins researchers named AAAS Fellows
11. Leibniz Prizes 2013: DFG honors 11 outstanding researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/27/2015)... Apr. 27, 2015 Profile Solutions, Inc. (OTC: ... security systems is pleased to announce that Dr ... consultant and member of its scientific advisory board. ... as a thought leader in technology-enhanced learning models. He ... and has published studies and books focused on online ...
(Date:4/20/2015)... 2015 The announcement comes as ... Records Management (GRM), Ireland,s foremost records ... Having built up an impressive track record of clients within ... within the records management sector in Dubai ... GCC staffbase and employ a further eight staff members at ...
(Date:4/14/2015)... Conn. , April 14, 2015 NXT-ID, ... a biometric authentication company focused on the growing mobile ... been nominated for the 2015 New York Design Awards ... The Design100, New York City Design Awards are part ... based on over 2,500 ratings from the marketplace, industry ...
Breaking Biology News(10 mins):Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 2Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 4Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 2Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 3NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3
... Center for Molecular Medicine (MDC) Berlin-Buch have gained new ... Michael Stilmann, Dr. Michael Hinz and Professor Claus Scheidereit ... damage within seconds, activates the transcription factor NF-kappaB, a ... program, which blocks programmed cell death. The activation of ...
... Andrews in the UK have found that the color of ... appear, and have found that diet may be crucial to ... in the December issue of Springer,s International Journal of ... of 54 Caucasian participants of both sexes were asked to ...
... While mothers have known that feeding their kids milk builds ... Institute at Intermountain Medical Center in Salt Lake City suggests ... as well and that inadequate levels of the vitamin ... and death, even among people who,ve never had heart disease. ...
Cached Biology News:How cells tolerate DNA damage -- start signal for cell survival program identified 2How cells tolerate DNA damage -- start signal for cell survival program identified 3Skin color gives clues to health 2New study links vitamin D deficiency to cardiovascular disease and death 2New study links vitamin D deficiency to cardiovascular disease and death 3
(Date:5/29/2015)... (PRWEB) May 29, 2015 Market ... (Chem-Report ) signed a partnership agreement for quality ... authorised to distribute and sell research reports worked ... at Partners Department, commented upon the agreement: “Chem-Report ... on key petroleum and chemical markets on global ...
(Date:5/29/2015)... Columbia, Pa. (PRWEB) May 29, 2015 ... Thermal Product Solutions with a request to design ... remove excess moisture from prescription medications being produced ... custom solution that includes a robotic gantry, heat-saving ... positions and dries trays of 3D-printed pills to ...
(Date:5/29/2015)... , May 29, 2015  Caris Life ... on fulfilling the promise of precision medicine, today ... that demonstrate the clinical utility of Caris Molecular ... profiling service, in helping to identify targeted treatment ... In each of the studies, results of which ...
(Date:5/29/2015)... SPRING, Md. and RESEARCH TRIANGLE PARK, ... Corporation (NASDAQ: UTHR ) announced today that Roger ... Therapeutics, will provide an overview and update on the company,s ... New York City . The presentation ... Thursday, June 4, 2015, at 11:00 AM Eastern Time, and ...
Breaking Biology Technology:Market Publishers Ltd and Chem-Report Sign Partnership Agreement 2Market Publishers Ltd and Chem-Report Sign Partnership Agreement 3New industrial oven with “pill pushing” robotic gantry precisely removes excess moisture from 3D-printed pharmaceuticals 2Multi-Platform Tumor Profiling from Caris Life Sciences Identifies Targeted Treatment Options for Patients with Rare and/or Aggressive Tumors 2Multi-Platform Tumor Profiling from Caris Life Sciences Identifies Targeted Treatment Options for Patients with Rare and/or Aggressive Tumors 3Multi-Platform Tumor Profiling from Caris Life Sciences Identifies Targeted Treatment Options for Patients with Rare and/or Aggressive Tumors 4Multi-Platform Tumor Profiling from Caris Life Sciences Identifies Targeted Treatment Options for Patients with Rare and/or Aggressive Tumors 5Multi-Platform Tumor Profiling from Caris Life Sciences Identifies Targeted Treatment Options for Patients with Rare and/or Aggressive Tumors 6
... , NEW YORK, Dec. 4 Stemline Therapeutics, Inc. ... agents, SL-401 and SL-501, in both in vitro and ... for poster presentation at the upcoming 51st Annual Meeting of the ... from December 5-8, 2009. The poster will be presented by Stemline,s ...
... , HOUSTON, Dec. 3 ... updated its facility to offer patients a second surgical option, ... that it currently performs. The first sleeve gastrectomy procedure at the ... on October 20, 2009. The patient is reported as doing ...
... , ... (OTC Bulletin Board: ACCP), today provided ... FDA approved treatment for oral mucositis, a debilitating side effect ... Access, partner, SpePharm, in six European countries, including the UK, ...
Cached Biology Technology:Stemline Therapeutics Announces Poster Presenting in vivo and Anti-Cancer Stem Cell Activity of SL-401 against Chronic Myeloid Leukemia (CML) at the 51st Annual Meeting of the American Society of Hematology (ASH) 2JourneyLite of Houston Now Offering Sleeve Gastrectomy 2Access Pharmaceuticals Provides Update on MuGard Commercial Launch in Europe 2Access Pharmaceuticals Provides Update on MuGard Commercial Launch in Europe 3Access Pharmaceuticals Provides Update on MuGard Commercial Launch in Europe 4
... Detection System is intended for use in ... by an in-house validated method for in ... target of interest. • ... a hybridization capture assay designed to detect ...
... maximum packaging efficiencies of cDNA and genomic DNA ... a test insert with Novagen's l vector arms, ... 10^8 pfu/g ligated l control DNA) are typically ... use; simply add up to 5 g of ...
Gridded Cell Culture Petri Dish (20 mm molded in base), tissue-culture treated...
Chicken Anti-Human DNA-directed RNA Polymerase II 7.6 Kd Polypeptide (POLR2L Polyclonal AntibodyOther Sub-Family: not assigned-Other Applications: ELISA, Western Blot...
Biology Products: