Navigation Links
Researchers identify a new gene involved in autophagy, the cellular recycling program
Date:1/21/2010

This release is available in Spanish.

All cells are equipped with a recycling programme to collect and remove unnecessary cellular components. Autophagy sequesters and digests aged organelles, damaged proteins and other components, which, if not disintegrated and recycled, threaten cell viability. Researchers at the Institute for Research in Biomedicine (IRB Barcelona) led by Antonio Zorzano, head of the Molecular Medicine Programme and senior professor of the University of Barcelona, have identified a new gene that favours cell autophagy. The article has been published in EMBO Reports, which highlights it in the section "Hot off the press".

One of the main challenges in biomedicine is to decipher the complete map of genes and their products, the proteins that regulates autophagy in cells. "The interest lies in its association with human diseases", says Zorzano. There is increasing evidence of a link between autophagy and the appearance and progression of cancer, neurodegenerative pathologies, infections and aging. For example, several studies demonstrate that some neurodegenerative diseases caused by the abnormal aggregation of proteins, such as Huntington's disease, are associated with reduced autophagy. Pharmacological induction of this process could help to remove the cellular protein aggregates and to relieve the symptoms.

Caroline Mauvezin, PhD student with Zorzano and first author of the article, says that "it is possible to envisage future therapies based on the modulation of autophagy". However, further knowledge about this pathway and its components are required as well as a complete understanding of the precise role of autophagy in each disease in order to be able to manipulate it for therapeutic purposes. "We have identified a new player and now we have to study it in depth", says Mauvezin.

DOR favours autophagy

The study reveals that the DOR protein is involved in the initial, and most unknown, stages of autophagy. DOR facilitates the formation of autophagosomes, the structures that envelop, capture and transport components to lysosomes. Autophagosomes fuse to lysosomes to form autolysosomes, where several enzymes finally remove the unwanted or harmful intracellular debris.

Using in vitro cells and the fruit fly Drosophila, the researchers have demonstrated that the autophagic capacity of a cell decreases in the absence of DOR. This new gene in the autophagic pathway opens up many avenues of study, for example examining whether DOR is active or silenced in tumour cells. But the scientists are prudent with respect to the planning of future studies. "First we have to determine the precise function of DOR in the autophagic pathway in rat models in vivo, in order to determine its relevance and to identify all the proteins that it is associated with in this context", explains Zorzano.


'/>"/>

Contact: Snia Armengou
sonia.armengou@irbbarcelona.org
34-934-037-255
Institute for Research in Biomedicine (IRB Barcelona)
Source:Eurekalert  

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Researchers discover new strategies for antibiotic resistance
8. Researchers find new taste in fruit flies: carbonated water
9. Binghamton University researchers investigate evolving malaria resistance
10. UIC researchers find promising new targets for antibiotics
11. Researchers develop simple method to create natural drug products
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers identify a new gene involved in autophagy, the cellular recycling program
(Date:4/14/2016)... AVIV, Israel , April 14, 2016 ... Behavioral Authentication and Malware Detection, today announced the appointment ... already assumed the new role. Goldwerger,s leadership ... BioCatch, on the heels of the deployment of its ... addition, BioCatch,s behavioral biometric technology, which discerns unique cognitive ...
(Date:3/29/2016)... 2016 LegacyXChange, Inc. (OTC: ... SelectaDNA/CSI Protect are pleased to announce our successful effort ... variety of writing instruments, ensuring athletes signatures against counterfeiting ... from athletes on LegacyXChange will be assured of ongoing ... Bill Bollander , CEO states, "By ...
(Date:3/21/2016)... March 22, 2016 Unique ... passcodes for superior security   ... provider of secure digital communications services, today announced it ... and offer enterprise customers, particularly those in the Financial ... and voice authentication within a mobile app, alongside, and ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... - FACIT has announced the creation of a ... Propellon Therapeutics Inc. ("Propellon" or "the Company"), to ... of first-in-class WDR5 inhibitors for the treatment of ... an exciting class of therapies, possessing the potential ... patients. Substantial advances have been achieved with the ...
(Date:6/23/2016)... 23, 2016  The Biodesign Challenge (BDC), a university ... to harness living systems and biotechnology, announced its winning ... New York City . ... showcased projects at MoMA,s Celeste Bartos Theater during the ... MoMA,s senior curator of architecture and design, and ...
(Date:6/23/2016)... 23, 2016 Apellis Pharmaceuticals, Inc. today ... trials of its complement C3 inhibitor, APL-2. The ... ascending dose studies designed to assess the safety, ... injection in healthy adult volunteers. Forty ... a single dose (ranging from 45 to 1,440mg) ...
(Date:6/23/2016)... ... June 23, 2016 , ... Regulatory Compliance Associates® Inc. ... a free webinar on Performing Quality Investigations: Getting to Root Cause. ... at no charge. , Incomplete investigations are still a major concern to the ...
Breaking Biology Technology: