Navigation Links
Researchers identify a molecule that increases the risk of cardiac insufficiency
Date:4/24/2009

This release is available in Spanish.

A team of scientists from the Center for Applied Medical Research (CIMA) of the University of Navarra has identified a key enzyme in the development of cardiac insufficiency. This enzyme is involved in the accumulation of fibrous tissues in the hearts of patients with chronic cardiac diseases and deterioration of heart functions.

The research project, published in the journal Hypertension, is part of a project of the "Red Europea de Excelencia en Hipertensin y Enfermedades Cardiovasculares" [European Network of Excellence in Hypertension and Cardiovascular Diseases], in which research groups from Belgium, the Netherlands, Italy, Great Britain, France, Germany, Finland and Poland are all participating. The project also forms part of the "Red Espaola de Investigacin de las Enfermedades Cardiovasculares" [Spanish Network for Research on Cardiovascular Diseases].

Today, cardiac insufficiency affects more than 1,250,000 Spanish men and women over the age of 45. More than half of these people have a life expectancy of less than five years. The accumulation of fibrosis in the heart has been proven to have a significant influence on the development of cardiac insufficiency among patients with chronic heart disease.

New methods for treating patients with heart disease

The research team from the CIMA analyzed the expression of Llysyl oxidase, an enzyme which regulates the amount of fibrous tissue in cardiac muscle. "By means of molecular and histological methods, we have found that the cardiac muscle in patients with cardiac insufficiency contains an excess of this enzyme as well as collagen fiber (which it produces). These factors are associated with the deterioration of cardiac functions," explained Dr. Begoa Lpez, Lead Researcher of the project.

According to the researchers, this project shows that some drugs prescribed for patients with cardiac insufficiency do not actually inhibit the enzyme lysyl oxidase, nor do they reduce fibrosis or improve heart functions. Other drugs however, which are less commonly used, do have these beneficial qualities. "Our work opens new possibilities for treating patients with heart disease through the inhibition of the enzyme. The development of cardiac insufficiency could thus be impeded," said Begoa Lpez.


'/>"/>

Contact: Oihane Lakar
oihane@elhuyar.com
34-943-363-040
Elhuyar Fundazioa
Source:Eurekalert

Related biology news :

1. Researchers discover that gene switches on during development of epilepsy
2. Researchers report moderately large potential for red tide outbreak in Gulf of Maine region
3. UT Southwestern researchers probe kidney damage, protection in lupus
4. Researchers use brain interface to post to Twitter
5. TGen researchers discover possible way to block the spread of deadly brain tumors
6. Burnham researchers present at 100th AACR Meeting
7. Yale researchers uncover secrets of salmonellas stealth attack
8. Singapore researchers first to transform carbon dioxide into methanol
9. Researchers identify specific lung cancer susceptibility gene
10. CSHL researchers explain process by which cells hide potentially dangerous DNA segments
11. Stem cell therapy makes cloudy corneas clear, according to Pitt researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/19/2017)... New York , April 19, 2017 ... competitive, as its vendor landscape is marked by the ... the market is however held by five major players ... Safran. Together these companies accounted for nearly 61% of ... of the leading companies in the global military biometrics ...
(Date:4/11/2017)... GARDENS, Fla. , April 11, 2017 /PRNewswire/ ... management and secure authentication solutions, today announced that ... by Intelligence Advanced Research Projects Activity (IARPA) to ... IARPA,s Thor program. "Innovation has been ... and IARPA,s Thor program will allow us to ...
(Date:4/5/2017)... , April 5, 2017  The Allen Institute ... Allen Cell Explorer: a one-of-a-kind portal and dynamic digital ... 3D imaging data, the first application of deep learning ... human stem cell lines and a growing suite of ... platform for these and future publicly available resources created ...
Breaking Biology News(10 mins):
(Date:5/22/2017)... ... May 22, 2017 , ... Baltimore biotech firm, ... Maryland Biohealth community in developing and issuing recommendations to grow Maryland's biohealth industry ... Hub by 2023. , The recommendations are contained in a ...
(Date:5/19/2017)... (PRWEB) , ... May 19, 2017 , ... In response ... treating gait disorders, Biodex Medical Systems, Inc. announces the release of their Gait Trainer ... has been joined with a biomedical system to aid in rehabilitating individuals with cerebral ...
(Date:5/18/2017)... ... ... Supplies Management (“CSM”), a Great Point Partners II (“GPP”) portfolio company, today announced two ... size over the past six months with the acquisition of businesses in Belgium and ... Chief Financial Officer. Roger has over 25 years of experience in finance and ...
(Date:5/18/2017)... CALIFORNIA (PRWEB) , ... May 17, 2017 , ... ... technological innovation and business process optimization firm for the life sciences and healthcare ... of the UDIs and Traceability for Medical Devices conference in Brussels, Belgium. , ...
Breaking Biology Technology: