Navigation Links
Researchers identify a molecule that increases the risk of cardiac insufficiency
Date:4/24/2009

This release is available in Spanish.

A team of scientists from the Center for Applied Medical Research (CIMA) of the University of Navarra has identified a key enzyme in the development of cardiac insufficiency. This enzyme is involved in the accumulation of fibrous tissues in the hearts of patients with chronic cardiac diseases and deterioration of heart functions.

The research project, published in the journal Hypertension, is part of a project of the "Red Europea de Excelencia en Hipertensin y Enfermedades Cardiovasculares" [European Network of Excellence in Hypertension and Cardiovascular Diseases], in which research groups from Belgium, the Netherlands, Italy, Great Britain, France, Germany, Finland and Poland are all participating. The project also forms part of the "Red Espaola de Investigacin de las Enfermedades Cardiovasculares" [Spanish Network for Research on Cardiovascular Diseases].

Today, cardiac insufficiency affects more than 1,250,000 Spanish men and women over the age of 45. More than half of these people have a life expectancy of less than five years. The accumulation of fibrosis in the heart has been proven to have a significant influence on the development of cardiac insufficiency among patients with chronic heart disease.

New methods for treating patients with heart disease

The research team from the CIMA analyzed the expression of Llysyl oxidase, an enzyme which regulates the amount of fibrous tissue in cardiac muscle. "By means of molecular and histological methods, we have found that the cardiac muscle in patients with cardiac insufficiency contains an excess of this enzyme as well as collagen fiber (which it produces). These factors are associated with the deterioration of cardiac functions," explained Dr. Begoa Lpez, Lead Researcher of the project.

According to the researchers, this project shows that some drugs prescribed for patients with cardiac insufficiency do not actually inhibit the enzyme lysyl oxidase, nor do they reduce fibrosis or improve heart functions. Other drugs however, which are less commonly used, do have these beneficial qualities. "Our work opens new possibilities for treating patients with heart disease through the inhibition of the enzyme. The development of cardiac insufficiency could thus be impeded," said Begoa Lpez.


'/>"/>

Contact: Oihane Lakar
oihane@elhuyar.com
34-943-363-040
Elhuyar Fundazioa
Source:Eurekalert

Related biology news :

1. Researchers discover that gene switches on during development of epilepsy
2. Researchers report moderately large potential for red tide outbreak in Gulf of Maine region
3. UT Southwestern researchers probe kidney damage, protection in lupus
4. Researchers use brain interface to post to Twitter
5. TGen researchers discover possible way to block the spread of deadly brain tumors
6. Burnham researchers present at 100th AACR Meeting
7. Yale researchers uncover secrets of salmonellas stealth attack
8. Singapore researchers first to transform carbon dioxide into methanol
9. Researchers identify specific lung cancer susceptibility gene
10. CSHL researchers explain process by which cells hide potentially dangerous DNA segments
11. Stem cell therapy makes cloudy corneas clear, according to Pitt researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/5/2017)... , April 5, 2017 Today ... announcing that the server component of the HYPR platform ... for providing the end-to-end security architecture that empowers biometric ... HYPR has already secured over 15 million users ... including manufacturers of connected home product suites and physical ...
(Date:4/4/2017)... 4, 2017   EyeLock LLC , a leader ... United States Patent and Trademark Office (USPTO) has issued ... linking of an iris image with a face image ... the company,s 45 th issued patent. ... timely given the multi-modal biometric capabilities that have recently ...
(Date:3/30/2017)... -- On April 6-7, 2017, Sequencing.com will host the world,s ... at Microsoft,s headquarters in Redmond, Washington ... health and wellness apps that provide a unique, personalized ... is the first hackathon for personal genomics and the ... the genomics, tech and health industries are sending teams ...
Breaking Biology News(10 mins):
(Date:9/19/2017)... ... September 19, 2017 , ... ... (NYS DFS) cybersecurity regulations have transitioned into full force and effect. ... in the state (“Covered Entities”) to conduct an annual, professional, comprehensive cybersecurity ...
(Date:9/18/2017)... ... September 18, 2017 , ... USDM ... firm for the life sciences and healthcare industries, announces Bryan Coddington ... What: Digital Transformation in Medical Device – The Journey to FDA Compliant Field ...
(Date:9/14/2017)... , ... September 14, 2017 ... ... the launch of its CliniControl™ (CC) product portfolio, clinically-relevant starting and ancillary ... translation of human Mesenchymal Stem/Stromal Cell (hMSC)-based therapies. The CliniControl product portfolio ...
(Date:9/14/2017)... ... September 14, 2017 , ... Cambridge Semantics , ... announced that its Anzo Smart Data Lake has been named a KMWorld ... solutions that help organizations succeed in surpassing their knowledge management goals. KMWorld searches ...
Breaking Biology Technology: