Navigation Links
Researchers identify a mechanism linking bariatric surgery to health benefits
Date:4/22/2014

Bariatric surgery has positive effects not only on weight loss but also on diabetes and heart disease. Researchers at the Sahlgrenska Academy and University of Cincinnati have shown that the health benefits are not caused by a reduction in the stomach size but by increased levels of bile acids in the blood. These findings, reported in Nature, indicate that bile acids could be a new target for treating obesity and diabetes.

Previous research from the Sahlgrenska Academy has demonstrated that obesity surgery is the only effective treatment for obesity and obesity-related diabetes.

However, the mechanisms that cause the positive effects have been unclear.

Positive effects caused by bile acids

Professor Fredrik Bckhed, in collaboration with Randy Seeley and coworkers from the University of Cincinnati in the US, has shown that the positive effects of bariatric surgery are likely caused by the surgery-induced increase in bile acids. The study, which is published online in the leading science journal Nature, focuses on a specific receptor called FXR, which is involved in bile acid signaling.

"Our study shows that signaling through FXR is essential for the beneficial effects of the surgery to be achieved. This is a major breakthrough in understanding how bariatric surgery affects metabolism and in the development of new treatment strategies", says Fredrik Bckhed.

Important future complement

The prevalence of obesity is increasing worldwide and it is not realistic to operate on all obese subjects. Furthermore, bariatric surgery is associated with a risk of complications. Treatment strategies based on the FXR receptor could therefore be an important future therapeutic approach.

Improves glucose metabolism

In this study, mice with or without the FXR gene underwent an operation termed vertical sleeve gastrectomy (VSG) in which approxima
'/>"/>

Contact: Fredrik Bäckhed
fredrik.backhed@wlab.gu.se
46-702-182-355
University of Gothenburg
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
3. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
4. UNH researchers find African farmers need better climate change data to improve farming practices
5. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
6. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
7. Researchers print live cells with a standard inkjet printer
8. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
9. Researchers reveal how a single gene mutation leads to uncontrolled obesity
10. Researchers discover novel therapy for Crohns disease
11. New paper by Notre Dame researchers describes method for cleaning up nuclear waste
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers identify a mechanism linking bariatric surgery to health benefits
(Date:5/19/2015)... 18, 2015 Fingerprint Cards (FPC) has ... FPC1145, FPC1155 and FPC1035 from one if its module partners. ... including Q3 2015 and the sensors will be used by ... values for 2015 hereby amount to 740 MSEK to date. ... 140 MSEK and a number of smaller orders not separately ...
(Date:5/19/2015)... DUBLIN , May 19, 2015 /PRNewswire/ ... ) has announced the addition of the  ... their offering.  ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ,A ... provides an in-depth analysis of the current ... introduction of gene-based tests, their working principles ...
(Date:5/14/2015)... Research and Markets ( http://www.researchandmarkets.com/research/5whpxg/fingerprint ) ... Market in Smart Mobile Devices " report to ... was a watershed year for fingerprint sensors in smartphones ... Apple gave fingerprint sensors a raison d,etre in the ... are a must-have feature in flagship smartphones. ...
Breaking Biology News(10 mins):Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2Global Genetic Testing Market Outlook 2018 2Global Smart Mobile Devices Fingerprint Sensors Market 2015-2019: Key Vendors are Authentec, Validity Sensors, Fingerprint Cards, Next Biometrics Group. IDEX, and Qualcomm 2
... that advanced biofuels made from cellulosic biomass are the ... renewable, clean, green, domestic source of transportation energy. Nature, ... sugars in grains, the complex polysaccharides in the cellulose ... woody material called lignin. For advanced biofuels to be ...
... Why do people with a hereditary mutation of the ... sickle-cell anemia prevalent in Africa) not contract severe malaria? ... of the Department of Infectious Diseases at Heidelberg University ... of the altered hemoglobin provides protection from severe malaria. ...
... recovery at one minute after a six-minute walking distance (6MWD) ... clinical worsening in patients with idiopathic pulmonary arterial hypertension (IPAH), ... first study to show that heart rate recovery at one ... strong predictor of clinical worsening in IPAH patients," said Omar ...
Cached Biology News:A corny turn for biofuels from switchgrass 2A corny turn for biofuels from switchgrass 3Protection from severe malaria explained 2Protection from severe malaria explained 3Heart rate recovery predicts clinical worsening in pulmonary hypertension 2
(Date:5/20/2015)... Agricultural firm H.J. Baker & Bro., Inc. ... Tiger-Sul. Since the purchase of Tiger Industries and ... 2005, H.J. Baker has leveraged the innovation of the ... portfolio of product offerings and solutions expertise. The deal ... innovation of Tiger-Sul, transforming the company into a leading ...
(Date:5/20/2015)... , May 20, 2015  Cypher Genomics, Inc., ... collaboration with Celgene Corporation to apply Cypher,s Coral ... that associate with patient response to innovative medicines. ... to help accelerate patient access to the right ... clinical research and development and potentially inform new ...
(Date:5/20/2015)... Carolina , 20. Mai 2015 ... für klinische Logistik (Clinical Logistics Organization/CLO) ... Geschäftsjahr 2014, das am 31. Dezember ... Unternehmen hat die Marktentwicklung übertroffen und ... - http://photos.prnewswire.com/prnh/20110930/NY78064LOGO ...
(Date:5/20/2015)... , May 20, 2015  HOSTING, the leading ... that it is an official partner of ... (CHIME) Cooperative Members Services Program. This unique ... managed cloud services and best practices derived ... CIOs and service providers, enabling member healthcare ...
Breaking Biology Technology:Agricultural Firm H.J. Baker & Bro., Inc., Celebrates 10 Years Since Acquisition Of Tiger-Sul 2Agricultural Firm H.J. Baker & Bro., Inc., Celebrates 10 Years Since Acquisition Of Tiger-Sul 3Cypher Genomics Collaborates with Celgene Corporation to Identify Novel Genomic Biomarkers 2Marken schließt Ergebnisse für das Geschäftsjahr 2014 ab 2HOSTING Named Partner of the CHIME Cooperative Member Services Program 2HOSTING Named Partner of the CHIME Cooperative Member Services Program 3
... 5 BioMarin,Pharmaceutical Inc. (Nasdaq: BMRN ) today ... present a company,update at the Credit Suisse 2008 Annual ... at 10:30 a.m. MST., Interested parties may access ... investor section of the BioMarin website, http://www.BMRN.com .,A ...
... (Nasdaq: PPHM ) today announced that senior ... Annual Healthcare Conference on,Tuesday, November 11, 2008 at ... at,the New York Palace Hotel in New York ... please visit:, http://www.rodmanandrenshaw.com/conferences?id=19 , About Peregrine Pharmaceuticals, ...
... EDMONTON, Nov. 5 /PRNewswire-FirstCall/ - BioMS Medical Corp (TSX: ... today,announced that Mr. Kevin Giese, President and CEO, will present ... York., WHEN: Monday November ... New York Palace Hotel, New York., About BioMS Medical ...
Cached Biology Technology:BioMarin to Present at the Credit Suisse Healthcare Conference 2BioMS Medical to present at Rodman and Renshaw Annual Healthcare Conference 2
... Thermo Electron's CryoMed Freezers for IVF ... (K021042) with precise control, ease of setup ... temperature and operation status are continuously displayed ... and the cycle data are printed by ...
... Vacuum pumps deliver critical performance for all ... control optimizes pump performance to suit all ... for convenient checking of proper oil levels ... pumps is designed to work with all ...
A powerful, easy-to-use solution, the SORVALL RC12BP Blood Processing System allows you to manufacture blood components quickly and cost-effectively while ensuring product quality, safety, and GMP co...
Economical and manually filled LN2 vacuum insulated storage container offers high capacity and low nitrogen consumption while offering convenient storage of samples....
Biology Products: