Navigation Links
Researchers identify a cell type that limits stroke damage
Date:1/27/2009

Quebec City, January 27, 2009A research team including Serge Rivest of University Laval's Faculty of Medicine has demonstrated the existence of a type of cells that limits brain damage after a stroke. The study was recently published in the online version of Nature Medicine.

Laboratory experiments showed that three days after a stroke, the affected area of the brain is 20% larger in mice without regulatory T (Treg) cells than in normal mice. Effects on locomotor control are also more severe in mice lacking this type of cells.

"These results lead us to believe that we could better preserve crucial functions like sight, speech, or control of the limbs if we rapidly stimulated the production of Treg cells in stroke victims," commented Professor Rivest. "We are particularly enthusiastic about this discovery because we already know what chemicals stimulate the production of Treg cells," continued the researcher. "So a treatment may be available in the not too distant future. We also believe that the protective effect of Treg cells could be used to treat other types of brain damage, especially that caused by head injury."

Part of the brain damage occurring after a stroke is caused by the body's immune response. Cells such as microglia and lymphocytes provoke harmful effects similar to those observed during nervous system infections. When performing their cleaning functions, these cells also attack healthy cells, enlarging the damaged area of the brain and threatening certain brain functions. Researchers had suspected the existence of a mechanism that slows this harmful effect of immune cells in the brain, but no one had yet been able to demonstrate it.

Treg cells, produced in the bone marrow and other organs of the immune system, migrate to the brain during the first few days after a stroke. They limit the extent of secondary damage by blocking the production of neurotoxins and modulating the action of lymphocytes and microglia in the brain.


'/>"/>

Contact: Jean-Franois Hupp
jean-francois.huppe@dc.ulaval.ca
418-656-7785
Universit Laval
Source:Eurekalert

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Researchers discover new strategies for antibiotic resistance
8. Researchers find new taste in fruit flies: carbonated water
9. Binghamton University researchers investigate evolving malaria resistance
10. UIC researchers find promising new targets for antibiotics
11. Researchers develop simple method to create natural drug products
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/22/2017)... VILNIUS, Lithuania , March 21, 2017 /PRNewswire/ ... identification and object recognition technologies, today announced the ... development kit (SDK), which provides improved facial recognition ... safety cameras on a single computer. The new ... algorithms to improve accuracy, and it utilizes a ...
(Date:3/22/2017)... Optimove , provider of the ... as 1-800-Flowers and AdoreMe, today announced two new ... Using Optimove,s machine learning algorithms, these features allow ... recommendations to their customers based not just on ... intent drawn from a complex web of data ...
(Date:3/22/2017)... 2017 Vigilant Solutions , a vehicle ... agencies, announced today the appointment of retired FBI special ... safety business development. Mr. Sheridan brings more ... a focus on the aviation transportation sector, to his ... Mr. Sheridan served as the Aviation Liaison Agent Coordinator ...
Breaking Biology News(10 mins):
(Date:3/22/2017)... N.Y. , March 22, 2017 Regeneron Pharmaceuticals, ... the Regeneron Genetics Center (RGC), U.K. Biobank and GSK to ... the U.K. Biobank resource. The initiative will enable researchers to ... new medicines for a wide range of serious and life ... ...
(Date:3/22/2017)... ... March 22, 2017 , ... ... tissue regeneration from small lab samples to full-size tissues, bones, even whole organs ... a vascular system that delivers blood deep into the developing tissue. , ...
(Date:3/22/2017)... COPENHAGEN, Denmark , March 22, 2017 /PRNewswire/ ... that utilizes its innovative TransCon technology to address ... announced financial results for the full year ended ... a significant year for our company as we ... become a leading, integrated rare disease company with ...
(Date:3/22/2017)... SANTA MONICA, Calif. , March 22, 2017 ... Council (MassMEDIC) are proud to announce their extended partnership ... Week will be headlined by the 21 st ... UBM,s BIOMEDevice Boston, taking place May 3-4, 2017. ... with Advanced Medical Technology Association (ADVAMED) President and ...
Breaking Biology Technology: