Navigation Links
Researchers identify Achilles heel of dengue virus, target for future vaccines
Date:4/11/2012

CHAPEL HILL, N.C. A team of scientists from the University of North Carolina at Chapel Hill and Vanderbilt University have pinpointed the region on dengue virus that is neutralized in people who overcome infection with the deadly pathogen. The results challenge the current state of dengue vaccine research, which is based on studies in mice and targets a different region of the virus.

"In the past researchers have relied on mouse studies to understand how the immune system kills dengue virus and assumed that the mouse studies would apply to people as well," said senior study author Aravinda M. de Silva, PhD, associate professor of microbiology and immunology at the UNC School of Medicine.

"Our study for the first time shows what region the immune system of humans target when they are fighting off the virus. The region on the virus targeted by the human immune system is quite different from the region targeted by mice."

The new research, which will appear online during the week of April 11-14, 2012 in the Proceedings of the National Academy of Sciences, was performed using blood cells from local travelers infected with dengue virus.

The global incidence of dengue has grown dramatically in recent decades, putting about half of the world's population at risk. Creation of a vaccine is complicated by the fact that there are four distinct, but closely related forms of the virus that cause dengue. Once people have recovered from infection with one form of the virus, they have lifelong immunity against that form.

But if they become infected with one of the other three forms of the virus, they increase their chances of developing the severe bleeding and sometimes fatal dengue hemorrhagic fever and dengue shock syndrome. The leading theory to explain why some people develop dengue hemorrhagic fever is that under some conditions the human immune response can actually enhance the virus and disease during a second infect
'/>"/>

Contact: Les Lang
llang@med.unc.edu
919-966-9366
University of North Carolina School of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers find critical regulator to tightly control deadly pulmonary fibrosis
2. Researchers identified a protein useful in predicting the risk of pulmonary metastases in breast cancer patients
3. Researchers identify genes that may help in ovarian cancer diagnosis and prognosis
4. Researchers use game to change how scientists study disease outbreaks
5. Notre Dame researchers using novel method to combat malaria drug resistance
6. BU researchers derive purified lung and thyroid progenitors from embryonic stem cells
7. Researchers report potential for a moderate New England red tide in 2012
8. Tales from the crypt lead researchers to cancer discovery
9. Researchers identify new regulator in allergic diseases
10. WHOI researchers, collaborators receive $1.4 million grant to study life in oceans greatest depths
11. Researchers unravel genetic mechanism of fatty liver disease in obese children
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... cutting-edge, innovative research on Alzheimer,s disease and the ... announced the recipients of new research grant awards, ... the District of Columbia, and five foreign countries. ... latest grants, BrightFocus has now provided more than ... The research projects funded this year reflect a ...
(Date:7/10/2014)... strong currents in the Straits of Mackinac reverse direction ... beneath the channel would quickly contaminate shorelines miles away ... new University of Michigan study commissioned by the National ... study and accompanying animations, oil from a hypothetical pipeline ... hours and Bois Blanc Island after two days. All ...
(Date:7/10/2014)... (July 10, 2014) Columbia University Medical Center (CUMC) ... therapies for patients with retinitis pigmentosa (RP), a leading ... its kind, takes advantage of induced pluripotent stem (iPS) ... which are then used as a patient-specific model for ... researchers led by Stephen H. Tsang, MD, PhD, showed ...
Breaking Biology News(10 mins):BrightFocus Foundation announces 55 new grantees in Alzheimer's and vision research 2BrightFocus Foundation announces 55 new grantees in Alzheimer's and vision research 3Straits of Mackinac 'worst possible place' for a Great Lakes oil spill 2Straits of Mackinac 'worst possible place' for a Great Lakes oil spill 3Patient-specific stem cells and personalized gene therapy 2Patient-specific stem cells and personalized gene therapy 3
... simple technique to make a common virus-killing material significantly more ... Andrew Barron and Qilin Li. Rather than trying to ... into the public domain. They hope wide adoption will save ... professors and their team reported in Environmental Science and ...
... ITHACA, N.Y. Scientists have identified the genes related ... for planting crops closer together, which has led to an ... Genetics , Jan. 9, 2011.) The study, led ... Agricultural Research Service (USDA-ARS) at Cornell and North Carolina ...
... MD (January 11, 2011)-- The Genetics Society of America ... Research Conference, March 30-April 3, 2011 at the Town ... This annual meeting brings together basic research scientists, ... the common fruit fly, whose hereditary traits Thomas Hunt ...
Cached Biology News:Virus killer gets supercharged 2Virus killer gets supercharged 3Technique allows researchers to identify key maize genes for increased yield 252nd Genetics Society of America Drosophila Research Conference announced 2
(Date:1/15/2014)... (PRWEB) January 15, 2014 DTS Language ... its Online Web Portal for Life Science organizations who need ... specify the subject matter of their documents in advance with ... help reduce time-to-delivery of translations, often a critical factor in ...
(Date:1/15/2014)... 2014 AudioNotch is the internet's leading ... the treatment of tinnitus. Patients listen to sound therapy ... a period of weeks to months, their tinnitus volume decreases. ... forms: Notched Music and Notched White Noise. Now, AudioNotch is ...
(Date:1/14/2014)... Washington, DC (PRWEB) January 14, 2014 ... session for Thursday, January 23, 2014 at 2pm EST ... Actionable Knowledge.” The topic focuses on how technology can ... mission critical decisions for government agencies. The online webinar ...
(Date:1/14/2014)... As pet owners drew up their lists of New Year,s resolutions ... care of my furry companion." Nowadays there are pet salons, dog ... to take the little canine or feline darlings along wherever mommy ... some pricey toys at the pet store. But anyone who has ...
Breaking Biology Technology:DTS Improves Efficiency for Life Science Document Translations 2Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2
... 15 NeoStem, Inc. (NYSE Amex: NBS ), which ... stem cells for future medical need, was featured on CBS2 News, ... and Tuesday morning July 14, 2009. , , ... of Dr. Christopher Centeno, a NeoStem consultant in stem cell therapies ...
... EXTON, Pa., July 15 Morphotek((R)), Inc., a subsidiary ... (CII), a privately held biotechnology company specializing in the development ... an evaluation and option agreement in which Morphotek will evaluate ... , The agreement with CII provides ...
... ... organizations was a key factor in the recent decision by the University of Florida Shands ... informatics needs. With the signing of the contract, the UFSCC has become the 25th ... ...
Cached Biology Technology:NeoStem Featured on CBS2 News; Success of Licensed Stem Cell Treatments Shown for Arthritis and Orthopedic Problems; Procedure to be Used by NeoStem Affiliate in China 2NeoStem Featured on CBS2 News; Success of Licensed Stem Cell Treatments Shown for Arthritis and Orthopedic Problems; Procedure to be Used by NeoStem Affiliate in China 3NeoStem Featured on CBS2 News; Success of Licensed Stem Cell Treatments Shown for Arthritis and Orthopedic Problems; Procedure to be Used by NeoStem Affiliate in China 4Morphotek(R), Inc. and Cancer Innovations, Inc. Announce Evaluation and Option Agreement for Therapeutic Monoclonal Antibodies 2Morphotek(R), Inc. and Cancer Innovations, Inc. Announce Evaluation and Option Agreement for Therapeutic Monoclonal Antibodies 3University of Florida Shands Cancer Center Selects OnCore(r) to Support its Collaborative Research Goals 2University of Florida Shands Cancer Center Selects OnCore(r) to Support its Collaborative Research Goals 3University of Florida Shands Cancer Center Selects OnCore(r) to Support its Collaborative Research Goals 4University of Florida Shands Cancer Center Selects OnCore(r) to Support its Collaborative Research Goals 5
BD Falcon, microtest ELISA plate 96 well flat-bottom, clear. Polystyrene, nonsterile, no lid (25/sp, 100/ca) Packaging: 25 / pack, 100 / case ...
... The Chemicon Detergent-OUT Kit is a ... from protein solutions. Removes detergents without ... load the protein solution on the Detergent-OUT ... solution. Micro columns are suitable for removing ...
... is a simple high performance method for ... detergents without significant dilution of protein solution. ... the Detergent-OUT Spin column and collect detergent ... suitable for removing detergent from a maximum ...
... microarrays are derived from frozen embedded tissue ... control procedures to ensure the highest quality. ... in one block, sectioned at a thickness ... slides. Sections are large (3-5 mm in ...
Biology Products: