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Researchers identify 4 genetic hotspots associated with psoriasis
Date:1/26/2009

soriasis and psoriatic arthritis. Polymorphisms of TNFAIP3 and TNI1 are also associated with two other autoimmune diseases, lupus and rheumatoid arthritis.

The number of DNA sites discovered to have strong associations with psoriasis has increased from one to 10 in the past 18 months. But many more polymorphisms probably are associated with the disease, according to Krueger. He believes the number that ultimately will be associated with psoriasis could be close to 300.

Once all the gene mutations connected to psoriasis have been indentified, researchers may be able to develop a genetic profile to predict the risk of developing the disease, the type of disease, and response to treatment. Krueger expects that quite soon a gene chip containing psoriasis-associated genetic mutations will be available to aid in the study of the disease.


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Contact: Phil Sahm
phil.sahm@hsc.utah.edu
801-581-2517
University of Utah Health Sciences
Source:Eurekalert

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