Navigation Links
Researchers identify 4 genetic hotspots associated with psoriasis
Date:1/26/2009

SALT LAKE CITY A genomewide scan of millions of genetic mutations has revealed four new DNA "hotspots" that affect the risk for psoriasis, a national group of researchers led by the University of Michigan and including several from the University of Utah School of Medicine has shown in a just-published study.

Appearing Jan. 25 in Nature Genetics online, the study also confirmed that two other previously identified DNA sites, discovered by researchers at the University of Utah and Celera Group, have a high association with psoriasis, an automimmune disease that can affect the joints and cause sore, itchy patches of skin in an estimated 7.5 million people in the United States.

The study was led by James T. Elder, M.D., Ph.D., a dermatologist who heads a group at the University of Michigan with long-standing interest in and an international reputation for its work in the genetics of psoriasis, and Goncalo Abecasis, Ph.D., a biostatistician at the University of Michigan. They elected to make the study a collaboration with researchers at Washington University in St. Louis and the University of Utah. Gerald G. Krueger, M.D., professor of dermatology and Benning Presidential Endowed Chair holder at the U of U, and his colleague Kristina Callis Duffin, M.D., assistant professor of dermatology, led the Utah portion of the study.

Krueger and Duffin said the study is important for several reasons.

"First, it shows the efficacy of using this (genomewide) approach to further understand this disease," Krueger said. "Second, it confirmed findings we reported in 2007 of polymorphisms (mutations) in the IL-12/23 pathways. Third, we now find a third polymorphism in this same cluster, IL-23A. Fourth, a treatment that knocks down IL-12 and IL-23 recently has been shown to be a very effective treatment for psoriasis."

This, plus the clustering of polymorphisms the IL-12/23 pathways, makes it apparent that this pathway is
'/>"/>

Contact: Phil Sahm
phil.sahm@hsc.utah.edu
801-581-2517
University of Utah Health Sciences
Source:Eurekalert

1

GOOD

Page: 1 2 3

Related biology news :

1. Researchers genetically link Lou Gehrigs disease in humans to dog disease
2. Texas Medical Center researchers win collaborative grants
3. Researchers describe protease inhibitor that may aid in diabetic retinopathy treatment
4. Researchers examine developing hearts in chickens to find solutions for human heart abnormalities
5. JDRF-funded researchers discover proteins regulating human beta cell replication
6. Researchers to use K-States BSL-3 Lab for $1 million study of fungus threatening wheat crops
7. Researchers identify potential new weapon in battle against HIV infection
8. U-M researchers discover new genes that fuse in cancer
9. Researchers first to see reactive oxygen species in vital enzyme
10. Dartmouth researchers find new protein function
11. Burnham researchers discover on switch for cell death signaling mechanism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/14/2009)... touching, or for Tasmanian devils biting each ... driven the dinosaurs to extinction through the transmission of ... f1000 Biology, highlights the ,paleobiological detective work, of David ... them to deduce that a protozoan parasite was to ... tyrannosaurid fossils. , The parasite,s modern-day equivalent, which infects ...
(Date:12/14/2009)... ON, December 10, 2009If you are spending the holidays ... wondering whether you would be better off with another ... , A research team from McMaster University and ... among cichlids, a species that lives in groups, members ... The results appear in the current issue of ...
(Date:12/14/2009)... In support of the United Nations Framework Convention ... European Environment Agency hosted the ,Bend the Trend, ... climate networking platform and premiere the screening of ... ,Environmental Atlas of Europe, a joint project of ... Programme (UNEP) and ESA, is a series of ...
Breaking Biology News(10 mins):'Environmental Atlas of Europe' unveiled at COP15 2ATMP Consulting Group Launches Service for Private Practice Physicians to Gain Funding and Implement Electronic Medical Record Standard 60303 1ATMP Consulting Group Launches Service for Private Practice Physicians to Gain Funding and Implement Electronic Medical Record Standard 60303 2ATMP Consulting Group Launches Service for Private Practice Physicians to Gain Funding and Implement Electronic Medical Record Standard 60303 3Presentations of Cempra Pharmaceuticals CEM 102 28fusidic acid 29 at the Infectious Diseases Society of America Annual Meeting Highlight Properties T 5811 1Presentations of Cempra Pharmaceuticals CEM 102 28fusidic acid 29 at the Infectious Diseases Society of America Annual Meeting Highlight Properties T 5811 2Presentations of Cempra Pharmaceuticals CEM 102 28fusidic acid 29 at the Infectious Diseases Society of America Annual Meeting Highlight Properties T 5811 3Teriparatide outperforms alendronate in treating steroid induced osteoporosis 60298 1Teriparatide outperforms alendronate in treating steroid induced osteoporosis 60298 2
... University of Manchester researchers are recruiting people with backache ... ?in the first ever study to discover if therapeutic ... and his team at the University's Centre for Rehabilitation ... sciatica for less than 12 weeks, are not pregnant ...
... A new study on the ability of liver cells to ... in regulating the immune response) found that such interactions do ... place. The results may help explain the altered immune responses ... useful in developing therapies for viral hepatitis and autoimmune diseases. ...
... Vaccine and Gene Therapy Institute (VGTI) at Oregon Health ... cells literally eat virus-infected cells while fighting disease at ... a clearer understanding of the body's immune system, it ... vaccine effectiveness. The research is published in the current ...
Other Biology News:Interaction between lymph and liver cells may affect immune response 2Interaction between lymph and liver cells may affect immune response 3OHSU researchers demonstrate how white blood cells cannibalize virus-infected cells 2
(Date:12/11/2009)... HILL, MA (12/11/2009) Boston College researchers have observed ... the first time and successfully harvested the elusive charges ... improved solar power efficiency, the authors report in the ... , When light is captured in solar cells, it ... But in order to snare these charges, the electrons ...
(Date:12/11/2009)... Algeta ASA (OSE: ALGETA), the,cancer ... center in the,US, the Tulane Cancer Center, ... phase III clinical study of Alpharadin in ... cancer,(CRPC) that has metastasized to the skeleton. ... (ALpharadin in SYMptomatic Prostate CAncer) study is ...
(Date:12/11/2009)... 11 Gwathmey, Inc., a pre-clinical contract ... staph aureus, and cardiovascular disease announces a new ... that Rosalie Dunn, Ph.D., has joined Gwathmey as ... 28 years of experience working with small businesses ... Gwathmey, Dr. Dunn managed multimillion dollar portfolios for ...
(Date:12/11/2009)... announces the opening of a NEW 2nd North American facility in ... and logistics center to support Esco,s growth in the North American ... temperature-controlled laboratory equipment. , ... Hatboro, PA (PRWEB) December ... North American facility in Marietta, OH. The facility will serve as ...
Breaking Biology Technology:Elusive 'hot' electrons captured in ultra-thin solar cells 2Algeta Announces First US Patient Randomized in ALSYMPCA Phase III Study at Tulane Cancer Center, New Orleans 2Algeta Announces First US Patient Randomized in ALSYMPCA Phase III Study at Tulane Cancer Center, New Orleans 3Algeta Announces First US Patient Randomized in ALSYMPCA Phase III Study at Tulane Cancer Center, New Orleans 4Rosalie Dunn, Ph.D., Joins Gwathmey, Inc. as Chief Executive Officer 2
... (Nasdaq:,CPHD) today announced the appointment of leading ... Fred Tenover, Ph.D., as,Senior Director of Scientific ... liaison,with the Infection Control community and will ... "The objective of the Cepheid HAI ...
... July 9 Axendia Inc., a,trusted advisor to ... CBI Research Inc., a provider of live and,electronic ... industries, today announced that Daniel R. Matlis President ... Manufacturing Execution,Systems for Life Sciences Congress" to be ...
... China, July 9 /Xinhua-PRNewswire-FirstCall/ --,China Biologic Products, Inc. ... of the leading plasma-based pharmaceutical companies in the,People,s ... Company has,commenced operations at its newly-constructed plasma collection ... He Station")., The Qi He Station has ...
Other Biology Technology:Noted Molecular Epidemiologist Joins Cepheid to Head Healthcare Associated Infection Consortium Program 2Noted Molecular Epidemiologist Joins Cepheid to Head Healthcare Associated Infection Consortium Program 3Axendia's President to Chair 3rd Annual MES for Life Sciences Congress 2China Biologic Products Begins Operation of its Newly Constructed Plasma Collection Station in Qi He County, Shandong Province 2China Biologic Products Begins Operation of its Newly Constructed Plasma Collection Station in Qi He County, Shandong Province 3
Multi-enzyme complex containing a wide range of carbohydrases, including arabanase, cellulase,b-glucanase, hemi-cellulase and xylanase Patent/trademark/license (electronic): A product of Novozyme Cor...
... Templates rich in GC content or ... difficult to amplify, and when subjected to ... Yield, specificity and consistency can be increased ... PCR amplification reactions. Polymer-Aide is an effective ...
... Application: The simple three step procedure (PCR, ... be completed in one day. The typical ... than 80%. , Features and Benefits: , ... cloned into any expression vector , High ...
Designed for use with all 96-well SPRI reagent kits. Used with round bottom 96-well microplates, and 96-well thermal cycling plates....
Biology Products: