Navigation Links
Researchers identified a protein useful in predicting the risk of pulmonary metastases in breast cancer patients
Date:4/10/2012

Researchers from the Bellvitge Biomedical Research Institute (IDIBELL) have shown that breast cancer cells that metastasize to the lung express a higher level of the protein peroxiredoxin 2 (PRDX2). The study suggests that the modulation of the levels of this protein could be a new therapeutic strategy to prevent lung metastases. The study results have been advanced in the online edition of the journal Oncogene.

PRDX2 is an oxidation-reduction enzyme that protects cells against free radicals and hence from oxidative stress. This is necessary in lung cells living in an environment with plenty of oxygen. In breast cancer cells, overexpression of PRDX2 also protects against oxidative stress and promotes growth and proliferation in the lungs, i.e. metastasis.

New therapeutic and preventive approach

The team coordinated by the researcher of the Biological clues of the invasive and metastatic phenotype group at IDIBELL, ngels Sierra, conducted several experiments in cell lines and in mice animal models which show that low levels of PRDX2's expression in tumour cells are sufficient to stop metastatic process in the lung.

"These findings," said Sierra, "suggest that modifying the expression of PRDX2 could lead to a new therapeutic approach to prevent lung metastases, as there are drugs already being tested in other diseases, capable of inhibiting the protein".

For Sierra, the next step "is to validate a sufficient number of patients with high expression of this protein as a risk biomarker of lung metastases in breast cancer. So, these patients could receive adjuvant therapy to chemotherapy to prevent lung metastases."

This study has been also developed by researchers from the INSERM of Lyon, the Biomedical Research Institute of Lleida, the University of Barcelona and the Institute of Photonic Sciences (ICFO).


'/>"/>

Contact: Arantxa Mena
comunicacio@idibell.cat
IDIBELL-Bellvitge Biomedical Research Institute
Source:Eurekalert

Page: 1

Related biology news :

1. NC State researchers get to root of parasite genome
2. Researchers find animal with ability to survive climate change
3. Researchers find an essential gene for forming ears of corn
4. Researchers note differences between people and animals on calorie restriction
5. Researchers study acoustic communication in deep-sea fish
6. Researchers discover that growing up too fast may mean dying young in honey bees
7. Researchers study how pistachios may improve heart health
8. UI researchers find potentially toxic substance present in Chicago air
9. Researchers develop new self-training gene prediction program for fungi
10. Case Western Reserve University researchers track Chernobyl fallout
11. Childrens National researchers develop novel anti-tumor vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/22/2017)... 2017 With the biometrics market to ... four technologies that innovative and agile startups must ... in the changing competitive landscape: multifactor authentication (MFA), ... "Companies can no longer afford to ... Dimitrios Pavlakis , Industry Analyst at ABI ...
(Date:2/14/2017)... , Feb. 14, 2017  Wake Forest Baptist ... as its new chief executive officer (CEO). Freischlag joins ... John D. McConnell , M.D., who last year ... at the Medical Center, after leading it since 2008. ... full scope of Wake Forest Baptist,s academic health system, ...
(Date:2/9/2017)... , Feb. 9, 2017 The biomass ... analysis of the biomass boiler market globally in terms ... of biomass boilers. The market for biomass boilers has ... type, end-user, application, and country/region. The market based on ... & forest residues, biogas & energy crops, urban residues, ...
Breaking Biology News(10 mins):
(Date:3/23/2017)... -- Research and Markets has announced the addition ... their offering. ... The Global Market for Bioproducts Should Reach $714.6 ... CAGR of 8.9%, This research report quantifies ... major product segments: bio-derived chemicals, biofuels, pharmaceuticals (biodrugs and herbal/botanicals), ...
(Date:3/23/2017)... -- GlobeImmune, Inc. today announced it has entered into a ... of its common stock to NantCell, Inc., a member ... sale of its common stock, NantCell has agreed to ... 200,000 shares, an estimated $2.0 million in value, of ... to enter into this strategic agreement with NantCell," said ...
(Date:3/23/2017)... SEATTLE , March 23, 2017 ... translational development of novel therapies in immuno-oncology, today ... to lead" small molecule compounds that activate interferon ... (RLR) pathways and demonstrate immune-mediated tumor regression in ... in the study who demonstrated complete tumor regression ...
(Date:3/23/2017)... Colo. , March 23, 2017  Agriculture technology ... Series A financing and note conversion to commercialize its ... Planet is focused on developing products that are simultaneously ... $30 million in the last 18 months. This latest ... North Bridge Venture Partners. The company,s ...
Breaking Biology Technology: