Navigation Links
Researchers hijack cancer migration mechanism to 'move' brain tumors
Date:2/16/2014

One factor that makes glioblastoma cancers so difficult to treat is that malignant cells from the tumors spread throughout the brain by following nerve fibers and blood vessels to invade new locations. Now, researchers have learned to hijack this migratory mechanism, turning it against the cancer by using a film of nanofibers thinner than human hair to lure tumor cells away.

Instead of invading new areas, the migrating cells latch onto the specially-designed nanofibers and follow them to a location potentially outside the brain where they can be captured and killed. Using this technique, researchers can partially move tumors from inoperable locations to more accessible ones. Though it won't eliminate the cancer, the new technique reduced the size of brain tumors in animal models, suggesting that this form of brain cancer might one day be treated more like a chronic disease.

"We have designed a polymer thin film nanofiber that mimics the structure of nerves and blood vessels that brain tumor cells normally use to invade other parts of the brain," explained Ravi Bellamkonda, lead investigator and chair of the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University. "The cancer cells normally latch onto these natural structures and ride them like a monorail to other parts of the brain. By providing an attractive alternative fiber, we can efficiently move the tumors along a different path to a destination that we choose."

Details of the technique were reported February 16 in the journal Nature Materials. The research was supported by the National Cancer Institute (NCI), part of the National Institutes of Health; by Atlanta-based Ian's Friends Foundation, and by the Georgia Research Alliance. In addition to the Coulter Department of Biomedical Engineering, the research team included Children's Healthcare of Atlanta and Emory University.

Treating the Glioblastoma multiforme cancer, al
'/>"/>

Contact: John Toon
jtoon@gatech.edu
404-894-6986
Georgia Institute of Technology
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Plastic shopping bags make a fine diesel fuel, researchers report
2. GVSU researchers draw link between zebra mussels, risk of algae blooms
3. Researchers discover epic new Burgess Shale site in Canadas Kootenay National Park
4. Researchers use genetic signals affecting lipid levels to probe heart disease risk
5. Researchers at UGent and VIB, discovered potential novel treatment against septic shock
6. Grant to help researchers find leukemias hiding places
7. Researchers discover rare new species of deep-diving whale
8. Presence of humans and urban landscapes increase illness in songbirds, researchers find
9. Researchers build 3-D structures to test breast cancer treatments
10. New hope: Researchers discover genetic mutations that cause rare and deadly lung disease
11. Stanford researchers discover how brain regions work together, or alone
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers hijack cancer migration mechanism to 'move' brain tumors
(Date:7/11/2014)... proteins that let nerve cells send out electrical signals, ... biological tactic that may offer a new way to ... environmentally responsible way. , Their findingthat naturally occurring ... harmless for a closely related onesuggests that insecticides can ... species like bees. A summary of the research, led ...
(Date:7/10/2014)... COLORADO SPRINGS, Colo. , June 27, 2014 ... announces that the National Institute of Standards and ... appointed 10 of its academic research and forensic ... Board (FSSB).  The Board is an element of ... These AAFS members are among the first appointments ...
(Date:7/10/2014)... 1, 2014 Smart technology emphasis grows ... and improved security: NXT-ID, Inc. (OTCBB: NXTD), eBay Inc. (NASDAQ: ... ), Apple Inc. (NASDAQ: AAPL ), Visa Inc. ... NXT-ID, Inc., (OTCQB: NXTD) a biometric authentication company focused ... the second series of 30 second spots on CNBC for ...
Breaking Biology News(10 mins):Potent spider toxin 'electrocutes' German, not American, cockroaches 2Potent spider toxin 'electrocutes' German, not American, cockroaches 3Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 2Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 3Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 2Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 3Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 4Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 5
... More than 20 million tons of plastic are placed in ... Missouri study suggest that some of the largely petroleum-based plastic ... from plants. Reducing the carbon footprint and the dependence on ... additional cash crop for farmers. "Making plastics from plants ...
... Institute of Standards and Technology (NIST) has developed ... an important quality assurance tool for measuring the ... dietary supplements. The new Standard Reference Material (SRM) ... with the Office of Dietary Supplements (ODS) at ...
... are two species of lice that infest humans: pubic lice, ... Pediculus humanus . A new article in BioMed Central,s ... for the separation of the two species. ... how he was struck by inspiration while pondering the question ...
Cached Biology News:'Green' plastics could help reduce carbon footprint 2New reference material can improve testing of multivitamin tablets 2
(Date:7/10/2014)... to the International Atomic Energy Agency (IAEA) the ... acquiring sufficient quantities of plutonium or highly enriched ... device. The IAEA also notes that most cases ... which can be challenging to detect with most ... appearing this week in the Journal of ...
(Date:7/10/2014)... June 17, 2014 Using microscopic polymer light ... gases, researchers at MIT,s Quantum Photonics Laboratory have ... in the parts-per-billion range. Optical sensors are ideal ... high signal-to-noise ratio, compact, lightweight nature, and immunity ... sensors had been developed before, the MIT team ...
(Date:7/10/2014)... Understanding the basis of psychiatric disorders has been extremely ... increase risk but are insufficient to cause disease. Now ... Cell Press journal Cell Stem Cell describe ... genetic risks interact with other risk factors or environmental ... Their research pinpoints a genetic variant that may predispose ...
(Date:7/10/2014)... that power our laptops and electric vehicles could store ... with the help of a sponge-like silicon material. ... graphite traditionally used in one of the battery,s electrodes, ... storage capacity of graphite. A paper describing the material,s ... in Nature Communications . , "Silicon has long ...
Breaking Biology Technology:Sensitive detection method may help impede illicit nuclear trafficking 2Swell new sensors 2New strategy could uncover genes at the root of psychiatric illnesses 2Silicon sponge improves lithium-ion battery performance 2Silicon sponge improves lithium-ion battery performance 3
... , , EMERYVILLE, Calif., ... today the publication of results from its study on the ... published in the International Journal of Cancer , describe ... effect induced by BN107 on estrogen receptor negative (ER-) breast ...
... , ... The Aesthetic Institute of New York and New Jersey, recently started using ... latest information in facial plastic surgery techniques, new products and beauty trends ... believe that using Twitter connects me to my patients on a more ...
... TSX symbol: SBS , CALGARY, Dec. 24 /PRNewswire-FirstCall/ - ... its progress on plant-produced Apo AI(Milano) in light of ... The Medicines Company, of Parsippany, New Jersey. , "The ... Apo AI(Milano) program is a strong endorsement of Apo ...
Cached Biology Technology:Bionovo Announces Publication Describing First Novel Dual mTOR Inhibitor, BN107, for the Treatment of Breast Cancer 2Bionovo Announces Publication Describing First Novel Dual mTOR Inhibitor, BN107, for the Treatment of Breast Cancer 3New York Plastic Surgeon Transforms His Practice Using Twitter Status Updates 2New York Plastic Surgeon Transforms His Practice Using Twitter Status Updates 3SemBioSys updates progress on Apo AI(Milano) 2SemBioSys updates progress on Apo AI(Milano) 3