Navigation Links
Researchers have identified a novel immunological mechanism of great importance for vaccine developm
Date:2/23/2014

Researchers have discovered the presence of a novel subtype of innate lymphoid cells in human spleen essential for the production of antibodies. This discovery, published in the prestigious journal Nature Immunology, clears the path to the identification of novel strategies to develop more efficient vaccines against encapsulated bacteria, considered highly virulent.

This work was done by the B cell Biology research group at IMIM (Institut Hospital del Mar d'Investigacions Mediques) in Barcelona, directed by Dr. Andrea Cerutti, ICREA research professor and leader in the field of B lymphocyte biology. Amongst the collaborators of the group are researchers from Icahn School of Medicine of Mount Sinai in New York and Riken Research Center for Integrative Medicine in Japan.

Innate lymphoid cells were recently described by the scientific community and represent the first line of immunological defence on our body surfaces, which are constantly exposed to bacteria, such as the intestine or skin. "For the first time it has been described both their presence and function in human spleen. We have discovered how these cells regulate the innate immune response of a subset of splenic B lymphocytes that are responsible to fight against encapsulated bacteria, causative agents of meningitis or pneumonia", says Dr. Giuliana Magri, member of the research group of B Cell Biology at IMIM and first author in the paper. This new finding improves our understanding on how the immune system protects us against infections.

"The current available vaccines against encapsulated bacteria confer only a limited protection in immunodeficient patients, and are too expensive to be implemented in developing countries. At the same time, we lack information on the underlying mechanisms that regulate B lymphocytes, which has been a major hurdle in the development of novel vaccine strategies. This makes the current discovery key in the design of novel more efficient and well-oriente
'/>"/>

Contact: Marta Calsina
mcalsina@imim.es
34-933-160-680
IMIM (Hospital del Mar Medical Research Institute)
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers pinpoint brain region essential for social memory
2. Discovery by Baylor University researchers sheds new light on the habitat of early apes
3. Kessler Foundation researchers study impact of head movement on fMRI data
4. Researchers propose a better way to make sense of Big Data
5. Researchers shed new light on the genetic history of the European beaver
6. Researchers identify new way to control stone fruit disease
7. Researchers warn against abrupt stop to geoengineering method
8. Researchers hijack cancer migration mechanism to move brain tumors
9. Plastic shopping bags make a fine diesel fuel, researchers report
10. GVSU researchers draw link between zebra mussels, risk of algae blooms
11. Researchers discover epic new Burgess Shale site in Canadas Kootenay National Park
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... of 3.5 billion years of evolutionary trial and error, ... it may be reaching a tipping point. , In ... data published in Science , an international team ... animals is contributing to what appears to be the ... event. , Since 1500, more than 320 terrestrial vertebrates ...
(Date:7/24/2014)... own microbial terroir, meaning the microbial populations found on ... product, creating the final flavor according to research published ... Environmental Microbiology . This is the first time investigators ... , Many sake makers inoculate with both bacteria ... the University of California, Davis, but he and his ...
(Date:7/24/2014)... 2014(BRONX, NY)Researchers at Albert Einstein College of Medicine ... The Michael J. Fox Foundation for Parkinson,s Research to ... Parkinson,s disease. This drug discovery project will test chemical ... of developing a drug that acts on an underlying ... for Parkinson,s help many people manage their symptoms, we ...
Breaking Biology News(10 mins):Stanford biologist warns of early stages of Earth's 6th mass extinction event 2Stanford biologist warns of early stages of Earth's 6th mass extinction event 3The microbes make the sake brewery 2Albert Einstein College of Medicine receives grant from the Michael J. Fox Foundation to fund drug discovery project targeting Parkinson's 2Albert Einstein College of Medicine receives grant from the Michael J. Fox Foundation to fund drug discovery project targeting Parkinson's 3
... there is a serious influenza outbreak will do little to ... findings of a study conducted at the UK Health Protection ... Sometimes a new type of influeza virus appears that causes ... case for flu. This happened, for example, in 1918, when ...
... defined the collective genome of the human gut, or colon. ... make up a motley "microbiome" that allows humans to digest ... fiber. , In a study published in the June ... for Genomic Research (TIGR) and their colleagues describe and analyze ...
... spend $21 billion for HIV/AIDS research, treatment, prevention, and ... study published in the July 1 issue of The ... it is--and more so than previously thought. , The ... , MD, MSc and colleagues at Massachusetts General Hospital ...
Cached Biology News:Air travel and pandemic flu 2Gut reaction: Researchers define the colon's genome 2Gut reaction: Researchers define the colon's genome 3New study calculates millions of years saved in lives of AIDS patients 2
(Date:7/24/2014)... 24, 2014  CorMedix Inc. (NYSE MKT: CRMD), ... therapeutic products for the prevention and treatment of ... notice on July 18, 2014 from the NYSE ... the CorMedix plan to regain compliance with continued ... the NYSE-MKT is continuing the Company,s listing and ...
(Date:7/24/2014)... Mich. , July 24, 2014  Neogen Corporation ... that future forecasts of its potential revenue from new ... call to investors and analysts on July 22, 2014, ... by analysts regarding this research. "It was ... questions about the potential of a new type of ...
(Date:7/24/2014)... 24, 2014 The first part of ... in First in Human Studies” will cover comprehensive clinical ... decisions. , With increasing R&D costs and declining industry ... to maximize the knowledge collected in early Phase I/IIa ... success in late stage development. , Next, the presenters ...
(Date:7/24/2014)... , July 24, 2014   Cypher Genomics, ... the appointment of Adam Simpson as ... provides rapid and comprehensive annotation and interpretation of ... reporting. "Cypher,s technology has the potential ... by enhancing diagnostic accuracy, optimizing therapeutic approaches and ...
Breaking Biology Technology:CorMedix, Inc. Granted Extension of NYSE-MKT Listing 2CorMedix, Inc. Granted Extension of NYSE-MKT Listing 3Neogen comments on SenesTech 2Best Practices for Optimizing Dose Escalation in First in Human Studies, New Webinar August 6th Hosted by Xtalks 2Cypher Genomics Announces the Appointment of Adam Simpson as President and COO to Advance Transformative Genome Interpretation Technology 2Cypher Genomics Announces the Appointment of Adam Simpson as President and COO to Advance Transformative Genome Interpretation Technology 3
... ORANGE, N.J., Oct. 18, 2011 Kessler Foundation announced ... Research Center as Director of the Human Performance and ... 2012. "The addition of Dr. Yue is ... physical and cognitive research aimed at improving rehabilitation for ...
... 18, 2011 /PRNewswire-Asia/ -- China Botanic Pharmaceutical Inc. (NYSE ... "Company"), a developer, manufacturer and distributor of botanical products, ... announced that the board increased the number of directors ... annual board meeting and appointed Mr. Zack Zibing Pan ...
... Oct. 18, 2011 Immune Design Corp. (IDC) announced ... the company as its new Chief Business Officer.  In ... years of pharmaceutical and biotechnology industry experience to lead ... advancing pipeline of novel therapeutic vaccines and immunotherapies for ...
Cached Biology Technology:Kessler Foundation Appoints New Director of Human Performance and Engineering Laboratory 2Kessler Foundation Appoints New Director of Human Performance and Engineering Laboratory 3China Botanic Appoints Zack Zibing Pan as an Independent Director and Chairman of its Audit Committee 2China Botanic Appoints Zack Zibing Pan as an Independent Director and Chairman of its Audit Committee 3Immune Design Corp. Appoints Guy F. Cipriani as Chief Business Officer 2
... TOPO Cloning Kits for Sequencing allow 5-minute cloning ... contain TOPO Cloning vectors with primer sites located ... PCR product insertion site. This minimizes the amount ... before reaching the sequence of your insert.vectors are ...
Blot Paper 7 x 8.5cm semi-dry western blots (order number RB-400)...
The product contains 10 ml Dynabeads Epoxy (4.5 m). Supplied at 4 x 10 8 beads/ml...
Request Info...
Biology Products: