Navigation Links
Researchers have identified a novel immunological mechanism of great importance for vaccine developm
Date:2/23/2014

Researchers have discovered the presence of a novel subtype of innate lymphoid cells in human spleen essential for the production of antibodies. This discovery, published in the prestigious journal Nature Immunology, clears the path to the identification of novel strategies to develop more efficient vaccines against encapsulated bacteria, considered highly virulent.

This work was done by the B cell Biology research group at IMIM (Institut Hospital del Mar d'Investigacions Mediques) in Barcelona, directed by Dr. Andrea Cerutti, ICREA research professor and leader in the field of B lymphocyte biology. Amongst the collaborators of the group are researchers from Icahn School of Medicine of Mount Sinai in New York and Riken Research Center for Integrative Medicine in Japan.

Innate lymphoid cells were recently described by the scientific community and represent the first line of immunological defence on our body surfaces, which are constantly exposed to bacteria, such as the intestine or skin. "For the first time it has been described both their presence and function in human spleen. We have discovered how these cells regulate the innate immune response of a subset of splenic B lymphocytes that are responsible to fight against encapsulated bacteria, causative agents of meningitis or pneumonia", says Dr. Giuliana Magri, member of the research group of B Cell Biology at IMIM and first author in the paper. This new finding improves our understanding on how the immune system protects us against infections.

"The current available vaccines against encapsulated bacteria confer only a limited protection in immunodeficient patients, and are too expensive to be implemented in developing countries. At the same time, we lack information on the underlying mechanisms that regulate B lymphocytes, which has been a major hurdle in the development of novel vaccine strategies. This makes the current discovery key in the design of novel more efficient and well-oriented therapies", concludes Dr. Andrea Cerutti.

This research involved in vitro studies with isolated cells from human spleen samples and in vivo studies performed with different mice models. The work explored the function of the innate lymphoid cells in homeostasis, in short, in the absence of any illness, opening the door in the future to study the possible implication of innate lymphoid cells in diverse pathological processes both at the mucosal and systemic level, as well as deepening our understanding of autoimmune and immunodeficient diseases.


'/>"/>

Contact: Marta Calsina
mcalsina@imim.es
34-933-160-680
IMIM (Hospital del Mar Medical Research Institute)
Source:Eurekalert

Related biology news :

1. Researchers pinpoint brain region essential for social memory
2. Discovery by Baylor University researchers sheds new light on the habitat of early apes
3. Kessler Foundation researchers study impact of head movement on fMRI data
4. Researchers propose a better way to make sense of Big Data
5. Researchers shed new light on the genetic history of the European beaver
6. Researchers identify new way to control stone fruit disease
7. Researchers warn against abrupt stop to geoengineering method
8. Researchers hijack cancer migration mechanism to move brain tumors
9. Plastic shopping bags make a fine diesel fuel, researchers report
10. GVSU researchers draw link between zebra mussels, risk of algae blooms
11. Researchers discover epic new Burgess Shale site in Canadas Kootenay National Park
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/20/2017)... 2017 Delta (NYSE: DAL ) customers now can ... at Reagan Washington National Airport (DCA). ... Delta launches biometrics to board aircraft at Reagan ... Delta,s biometric boarding pass experience that ... now integrated into the boarding process to allow eligible Delta SkyMiles Members ...
(Date:5/23/2017)... -- Hunova, the first robotic gym for the rehabilitation and functional motor sense ... Genoa, Italy . The first 30 robots will be available ... USA . The technology was developed and patented at the IIT ... Movendo Technology thanks to a 10 million euro investment from entrepreneur Sergio ... ...
(Date:4/24/2017)... 24, 2017 Janice Kephart , ... Identity Strategy Partners, LLP (IdSP) , today issues ... President Trump,s March 6, 2017 Executive Order: ... vetting can be instilled with greater confidence, enabling ... all refugee applications are suspended by until at ...
Breaking Biology News(10 mins):
(Date:9/19/2017)... ... September 19, 2017 , ... ... (NYS DFS) cybersecurity regulations have transitioned into full force and effect. ... in the state (“Covered Entities”) to conduct an annual, professional, comprehensive cybersecurity ...
(Date:9/18/2017)... --  Montrium , a growing leader in Electronic Trial Master ... groundbreaking non-profit research organization, Multidisciplinary Association for Psychedelic Studies (MAPS). ... MAPS Public Benefit ... ... to MDMA for the treatment of Posttraumatic Stress Disorder (PTSD). MAPS ...
(Date:9/14/2017)... Lafayette, Ind (PRWEB) , ... ... ... of AMRI’s Global Analytical Services, formally introduces its flexible scientist program (FSP)-- ... offers volume-based, preferred-rate pricing. The FSP, which combines SSCI’s extensive project-based analytical ...
(Date:9/14/2017)... ... September 14, 2017 , ... AxioMed is pleased ... Australia. Dr. Steven Yang completed the procedure on a 35-year-old female patient suffering ... lumbar disc at level L5-S1. The patient failed conservative treatments prior to undergoing ...
Breaking Biology Technology: