Navigation Links
Researchers have identified a gene with a key role in neuronal survival
Date:4/16/2012

Researchers at the Institute of Neurosciences at Universitat Autnoma de Barcelona (INc-UAB) identified the fundamental role played by the Nurr1 gene in neuron survival associated with synaptic activity. The discovery, published in the Journal of Biological Chemistry, allows scientists to study a new target that could help to understand the relationship between alterations in neural connections, which are known to cause early cognitive deficit, and the neurodegeneration characteristic of Alzheimer's disease.

During the development of the brain, hundreds of thousands of neurons die if they do not establish the necessary connections - synapses - with their cell targets. The process of regulating neuron survival and death is fundamental in the organization of brain connections forming the adult brain.

The effect of synaptic activity on the survival of these neurons however is not limited to the developing brain; it is also fundamental in the adult brain. The loss of synaptic activity, which results into the characteristic cognitive impairment seen in neurodegenerative diseases such as Alzheimer's, precedes and contributes to the neuronal death observed in these pathologies. Despite the importance of this process, there is no exact knowledge of the molecular mechanisms implied in neuron survival generated by this activity.

In the study directed by Jos Rodrguez lvarez, researcher of the UAB Institute of Neurosciences, scientists determined the relation of a gene and the neuron survival regulated by synaptic activity. Through a massive analysis of gene activity, researchers identified several dozens of genes whose functions are regulated by this activity. Of all the genes, the research demonstrates the key role played by the Nurr1 gene in the survival of neurons. Among the discoveries made, researchers observed that when the activity of this gene is silenced, the neuron dies. The research concludes that this identification provides a bet
'/>"/>

Contact: Maria Jesus Delgado
MariaJesus.Delgado@uab.cat
34-935-814-049
Universitat Autonoma de Barcelona
Source:Eurekalert

Page: 1 2

Related biology news :

1. NC State researchers get to root of parasite genome
2. Researchers find animal with ability to survive climate change
3. Researchers find an essential gene for forming ears of corn
4. Researchers note differences between people and animals on calorie restriction
5. Researchers study acoustic communication in deep-sea fish
6. Researchers discover that growing up too fast may mean dying young in honey bees
7. Researchers study how pistachios may improve heart health
8. UI researchers find potentially toxic substance present in Chicago air
9. Researchers develop new self-training gene prediction program for fungi
10. Case Western Reserve University researchers track Chernobyl fallout
11. Childrens National researchers develop novel anti-tumor vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... July 1, 2014 Smart technology emphasis ... convenience and improved security: NXT-ID, Inc. (OTCBB: NXTD), eBay Inc. ... GOOG ), Apple Inc. (NASDAQ: AAPL ), Visa ... MA) NXT-ID, Inc., (OTCQB: NXTD) a biometric authentication company ... that the second series of 30 second spots on CNBC ...
(Date:7/10/2014)... Conn. , July 2, 2014 NXT-ID, Inc., (OTCQB: ... reports that CEO Mr. Gino Pereira was interviewed ... show in Tampa Florida . Mr. Pereira ... host Cedric Harris and how the Wocket™ aims ... alternative.  Cedric Harris tells Gino ...
(Date:7/10/2014)... , July 7, 2014 Fingerprint Cards, ... major design win (DW). A Chinese Top 5 smartphone OEM ... start of mass production in October 2014.   ... Top 5 smartphone OEM, which has a planned date for ... target sales volume for this phone of 3 million units. ...
Breaking Biology News(10 mins):Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 2Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 3Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 4Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 5Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 2Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 3Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 4FPC Wins DW for 1021 Touch Sensor for Flagship Smartphone from Chinese Top 5 Smartphone OEM 2
... can be converted to electricity, potentially providing power for sensors, ... researchers at Case Western Reserve University report. The finding ... the country that could bring the creation of insect cyborgs ... out of science fiction and into reality. In this case, ...
... In the two and a half years since Adam Bogdanove, ... Pathology and Microbiology, along with Matthew Moscou, a former graduate ... from plant pathogenic bacteria find and bind specific sequences in ... discovery. Last year it was first shown that the ...
... cost-effective, a group of researchers from National Tsing Hua University ... have created a DNA-based memory device that is "write-once-read-many-times" (WORM), ... to encode information. The device, described in a paper accepted ... a thin film of salmon DNA that has been embedded ...
Cached Biology News:Implanted biofuel cell converts bug's chemistry into electricity 2Implanted biofuel cell converts bug's chemistry into electricity 3ISU scientist helps find structure of gene-editing protein named Method of the Year 2
(Date:7/10/2014)... 10, 2014 Product and process ... low abundance and are often “lost in the ... , Join presenters Dr. Rowel Tobias, Senior Scientist, ... Anders, Head of Quality at Nanotherapeutics, Inc., to ... can speed detection and quantitation while achieving the ...
(Date:7/10/2014)... Unraveling life’s mysteries can intrigue, amaze, and ... purchased a DNA test to unravel the ... a lifetime of memories, sharing, and closeness. In fact, ... genuinely brought the family closer together. , Recently, ... history and prior to taking the genetic ancestry ...
(Date:7/10/2014)... July 10, 2014 Senior supply chain ... professional associations, addressed the challenges of “Reducing Cost, Lead ... Industries” through strategic sourcing. Describing the partnership of the ... Supply Chain Management Institute ( SCMI) of the ... June 24 at the Kroc Institute of Peace and ...
(Date:7/10/2014)... PROVO, Utah , July 10, 2014 ... genome annotation and interpretation, today announced an ... sequencing (NGS) analytics for Lineagen,s NextStep Dx ... evaluation of neurodevelopmental and neurological disorders, currently ... chromosomal microarray (CMA) testing service used by ...
Breaking Biology Technology:Novel Ms Techniques Speed Detection of Biopharmaceutical Product and Process Impurities, New Webinar Hosted by Xtalks 2Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 2Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 3Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 4Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 5Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 2Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 4Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 3Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 4
... the growing open source clincial trials software. This release contains ... regulated industry sponsored clinical trials. , ... ... announces the availability of OpenClinica 2.5, the popular open source ...
... Mass., Sept. 19 Boston Scientific,Corporation (NYSE: BSX ... Life,Sciences Conference, which is being held September 22 - ... Chief Executive Officer, will make a,30-minute presentation which will ... Thursday, September 25, beginning at approximately 9:00,a.m. ET., ...
... Sept. 19 Abbott (NYSE:,ABT) will announce its 2008 ... market opens., The announcement will be followed by ... a.m. Central time (9 a.m. Eastern), and will be,accessible ... An archived edition of the call will be,available after ...
Cached Biology Technology:Akaza Research Releases New Version of OpenClinica Electronic Data Capture (EDC) Software; Targets Industry Clinical Trials 2Akaza Research Releases New Version of OpenClinica Electronic Data Capture (EDC) Software; Targets Industry Clinical Trials 3
Kit for BASE20/50 dual control unit, includes mounting plate, HOLDER50T, HEATERPAD50, SRTDX temperature probe(s)....
... 10 nM is available for in ... described in: Z. Hassani, G.-F. Lemkine, P. ... and B.-A. Demeneix. Lipid-mediated siRNA delivery down ... brain at picomolar levels. J. Gene Med., ...
... The IHC Select Immunoperoxidase Secondary Detection ... rat or goat IgG in the Primary ... antigens present in the specimen. Any excess ... Secondary Antibody Reagent (conjugated to biotin) is ...
... Cellular uptake of long double stranded RNA ... interference in a diverse group of organisms ... RNA interference leads to the inhibition of ... of the target messenger RNA (mRNA). Attempts ...
Biology Products: