Navigation Links
Researchers have a nose for how probiotics could affect hay fever
Date:11/26/2013

A study has shown that a daily probiotic drink changed how cells lining the nasal passages of hay fever sufferers reacted to a single out-of-season challenge. However, it did not lead to significant changes in hay fever symptoms, although this challenge test may not have accurately represented natural allergen exposure.

Our immune system must distinguish between "friends" that can be beneficial to our health and "foes" that can have harmful effects. There is now a growing body of evidence that the gut microbiota, the trillions of bacteria that live in our gut, influences that recognition. When it fails an immune response occurs. This is the case with hay fever, or seasonal allergic rhinitis, when the immune system reacts to pollen or fungal spores.

Previously, a research team at the Institute of Food Research (IFR) found that taking a drink containing the probiotic bacterium Lactobacillus casei changed how our immune system responds to grass pollen, measured through changes in molecules produced by the immune system.

A new study, published in the journal PLOS ONE, shows for the first time how these probiotics can interact with cells in our gut to produce systematic changes in cells lining our nasal cavity.

Funded by Yakult and the Biotechnology and Biological Sciences Research Council (BBSRC), clinicians and scientists at IFR and the University of East Anglia (UEA) on the Norwich Research Park gave 60 hay fever sufferers daily drinks for 16 weeks, outside of the hay fever season. One group was given a drink containing Lactobacillus casei Shirota, and the other group received very similar drinks without the probiotic. The study was double-blinded and placebo controlled, so neither the volunteers nor the scientists knew which group was receiving the probiotic. Samples were taken from the volunteers' nasal cavities and blood, both before and after being challenged with pollen to trigger their allergy. This was then repeated at the end of the 16-week intervention. Clinical measurements of the symptoms of hay fever were also recorded.

Volunteers who received the probiotic drink saw changes in allergic inflammation in their nasal lining, as well as changes in their blood, that are associated with immune responses. This is strong evidence of how the gut microbiota can influence cells of the gut lining, and have a systematic influence on our bodies and distant cells, such as those lining our nasal passages. But despite this, the probiotic had no detectable effect on the symptoms of hay fever.

Hay fever is a complicated condition to assess, and mimic in a clinical setting. The researchers used a single allergy challenge, applied to the volunteers' nasal passage, to provide a standard, reproducible test to help ensure all the subsequent results are comparable. In the real world hay fever is usually triggered by longer term exposure to the allergen, variable in strength and timing over a period of days or weeks. The IFR researchers are now exploring the possibility of carrying out a seasonal study to investigate whether the changes in the nasal mucosa seen in this single challenge study relate to changes in hay fever symptoms triggered by a more realistic natural exposure to pollen.


'/>"/>

Contact: Andrew Chapple
andrew.chapple@ifr.ac.uk
44-016-032-514-590
Norwich BioScience Institutes
Source:Eurekalert  

Related biology news :

1. 4 Johns Hopkins researchers named AAAS Fellows
2. Researchers use nanoscale patches to sensitize targeted cell receptors
3. 2 Cleveland Clinic researchers honored for contribution to science
4. Researchers describe 1 mechanism that favors rejection in transplantation of porcine cartilage in humans
5. UCLA, Emory researchers find a chemical signature for fast form of Parkinsons
6. Researchers map brain areas vital to understanding language
7. Researchers gain fuller picture of cell protein reactions
8. Scripps oceanography researchers engineer breakthrough for biofuel production
9. USF researchers show invasive sparrows immune cells sharpen as they spread
10. Researchers use CT and 3-D printers to recreate dinosaur fossils
11. Natural compound mitigates effects of methamphetamine abuse, University of Missouri researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers have a nose for how probiotics could affect hay fever
(Date:3/14/2016)... March 14, 2016 http://www.apimages.com ... --> - Renvoi : image disponible via ... --> --> DERMALOG, le ... de nouveaux lecteurs d,empreintes digitales pour l,enregistrement des ... sera utilisé pour produire des cartes d,identité aux ...
(Date:3/10/2016)... -- --> --> ... Access Management Market by Component (Provisioning, Directory Services, Password ... Size, by Deployment, by Vertical, and by Region - ... is estimated to grow from USD 7.20 Billion in ... Compound Annual Growth Rate (CAGR) of 12.2% during the ...
(Date:3/9/2016)... , March 9, 2016 ... government identified that more than 23,000 public service employees ... had been receiving their salary unlawfully.    --> ... country,s government identified that more than 23,000 public service ... or had been receiving their salary unlawfully.    ...
Breaking Biology News(10 mins):
(Date:5/27/2016)... Jersey and READING, ... -- Indegene ( http://www.indegene.com ), ... marketingorientierten Lösungen für die Life-Science-Branche, Pharmaunternehmen und ... bekannter weltweiter Anbieter von innovativen wissenschaftlichen Support-Services ... des Starts von IntraScience heute den Ausbau ...
(Date:5/26/2016)... Jersey and READING, England ... Indegene ( http://www.indegene.com ), a leading global ... life science, pharmaceutical and healthcare organisations and TranScrip ... innovative scientific support throughout the product lifecycle, today ... the launch of IntraScience.      (Logo: ...
(Date:5/26/2016)... ... 26, 2016 , ... After several promising treatments in Panama ... City of Knowledge in Panama, a 6 year-old Duchenne’s muscular dystrophy patient received ... year following FDA approval of a second application for a single patient, investigational ...
(Date:5/25/2016)... ... May 25, 2016 , ... Lajollacooks4u has become a ... consistently been rated one of its top attractions. Fortune 500 companies, such as ... in a unique and intimate team-building experience. , Each event kicks off with an ...
Breaking Biology Technology: