Navigation Links
Researchers harness the power of plants to fight hemophilia
Date:3/30/2010

Hemophilia, a disease linked with legends of European monarchs, frail heirs and one flamboyant charlatan called Rasputin, still afflicts many people today.

And the very treatments that can help can also put patients' lives at risk.

The standard treatment is infusion with an expensively produced protein that helps the blood to clot. But in some patients the immune system fights the therapy, and in a subset of those, it sets off an allergic reaction that can result in death.

Now researchers at the University of Florida and the University of Central Florida have devised a way that potentially could help patients develop tolerance to the therapeutic protein before they are in need of treatment.

They genetically modified plants to encapsulate the tolerance-inducing protein within cell walls so that when ingested, it can travel unscathed through the stomach and be released into the small intestines where the immune system can act on it. The low-cost plant-based system, now being tested in mice, eventually could help improve the lives of many people who have hemophilia and dramatically reduce related health-care costs. The approach also has the potential for use with other conditions such as food allergies and autoimmune diseases.

"We're hoping that our research will, in the future, result in better and more cost-effective therapies," said Roland Herzog, Ph.D., an associate professor of pediatrics, molecular genetics and microbiology in the UF College of Medicine and a member of the UF Genetics Institute, who was one of the study's leaders.

The findings were published Monday in the Proceedings of the National Academy of Sciences.

Hemophilia is characterized by defects in the gene that produces a protein required for blood to clot. People with hemophilia can suffer from spontaneous internal bleeding or severe bleeding resulting from minor injuries. Males get the disease, which is linked to the X chr
'/>"/>

Contact: Czerne M. Reid
czerne@ufl.edu
352-273-5814
University of Florida
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. U of I researchers say foliar fungicides may not be the answer for hail-damaged corn
2. Researchers look at reducing yield loss for crops under stress
3. UT Southwestern researchers find clues to TB drug resistance
4. U of I researchers identify new soybean aphid biotype
5. Researchers equip robot sub with sensory system inspired by blind fish
6. JDRF funded researchers test topical drug to treat diabetic macular edema
7. IU researchers target vascular disease linked to cancer-causing gene mutation
8. NYU School of Medicine presents biomedical researchers Dart/NYU Biotechnology Achievement Awards
9. Princeton researchers find that high-fructose corn syrup prompts considerably more weight gain
10. Researchers find Clostridium difficile is more common than MRSA in southeast community hospitals
11. Einstein researchers discover 2 new ways to kill TB
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... is available in German . ... up gases similar to a sponge that soaks up ... storing hydrogen or greenhouse gases. However, loading of many ... of Technology (KIT) now report in Nature Communications ... the MOF surface. This can be prevented by water-free ...
(Date:7/31/2014)... July 31, 2014 -- Do people make a rational ... raise them that way? Is it a matter of ... and a colleague from Rice University say that neither ... people lean left while others lean right. , A ... deep-seated psychology are at the core of political differences, ...
(Date:7/31/2014)... first discovered the photovoltaic effect in 1839, humankind has ... sunlight for its own purposes. In a new research ... FASEB Journal , scientists may have ... sunlight by focusing on a naturally occurring combination of ... conservationor persistence over time and across speciessuggests that this ...
Breaking Biology News(10 mins):Free pores for molecule transport 2Scientists find growing consensus: Political attitudes derive from body and mind 2Scientists shine bright new light on how living things capture energy from the sun 2
... the American Association of University Women (AAUW), will be ... Meeting of the Entomological Society of America (ESA). Her ... on Sunday, November 13, 2011. An important subtheme ... area where ESA President Delfosse feels there is an ...
... Researchers at Hewlett Packard and the University of ... physical and chemical properties of an electronic device that ... Memristors, short for memory resistors, are a newly ... have inspired experts to seek ways of mimicking the ...
... Gene expression is the process of converting the ... product such as a protein or any of several ... gene programs regulated by different physiological processes throughout the ... specialized cell. But a new study by researchers from ...
Cached Biology News:Christianne Corbett to speak at Entomology 2011 2'Computer synapse' analyzed at the nanoscale 2Plasticity of hormonal response permits rapid gene expression reprogramming 2
(Date:7/31/2014)... Graphite Metallizing Corporation announces GRAPHALLOY® ... bearings are uniquely suited to prevent loss of lubrication ... the high temperatures . , Recently, a manufacturer ... engineers at Graphite Metallizing to overcome problems with movement ... operation, pans containing blocks of powder mixture are loaded ...
(Date:7/31/2014)... ALBANY, New York , July 31, 2014 /PRNewswire/ ... published by Transparency Market Research "Electrodes for Medical Devices ... Fetal Scalp Electrodes, Therapeutic Electrodes - TENS, Pacemakers, Defibrillators, ... Share, Growth, Trends and Forecast, 2013 - 2019," the ... USD 633.6 million in 2012 and is estimated to ...
(Date:7/31/2014)... Francisco, California (PRWEB) July 31, 2014 ... systems that inform therapeutic decision-making in oncology, today announced ... August 14, 2014 to discuss the Company's financial results ... provide an update about the business in the current ... audio call beginning on Thursday, August 14, 2014, at ...
(Date:7/31/2014)... 2014  Smith & Nephew (LSE:SN, NYSE: ... today announced its entry into the forefoot market ... Repair System. Comprised of three separate repair options, ... ligament repair and reconstruction, a metatarsal osteotomy guide, ... (PIP) fusion, also known as hammer toe correction. ...
Breaking Biology Technology:Graphite Metallizing Announces Bearings for High Temperature Oven Applications 2Graphite Metallizing Announces Bearings for High Temperature Oven Applications 3Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 2Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 3Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 4Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 5Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 6CollabRx, Inc. Schedules First Quarter Fiscal Year 2015 Financial Conference Call and Business Update 2Smith & Nephew scores a HAT-TRICK with its entry into the high-growth hammer toe repair market 2Smith & Nephew scores a HAT-TRICK with its entry into the high-growth hammer toe repair market 3Smith & Nephew scores a HAT-TRICK with its entry into the high-growth hammer toe repair market 4
... N.C., May 11, 2011 Micell Technologies, Inc. ... presented at the EuroPCR conference in Paris, France ... "MiStent DES: A Novel Third Generation DES with ... The MiStent Drug-Eluting Coronary Stent System ("MiStent DES") ...
... 2011 Reportlinker.com announces that a new market ... Healthcare Information Technology ... REPORT HIGHLIGHTS * BCC estimates ... technologies covered in this report at more than ...
... Research being presented at Digestive Disease Week ... benefits for qualifying patients undergoing bariatric surgery, the ... considered when determining whether the surgery is appropriate ... of physicians and researchers in the field of ...
Cached Biology Technology:Micell Technologies Reports Preclinical Data for MiStentâ„¢ Drug-Eluting Coronary Stent to be Presented at EuroPCR 2Micell Technologies Reports Preclinical Data for MiStentâ„¢ Drug-Eluting Coronary Stent to be Presented at EuroPCR 3Reportlinker Adds Healthcare Information Technology 2Reportlinker Adds Healthcare Information Technology 3Reportlinker Adds Healthcare Information Technology 4Reportlinker Adds Healthcare Information Technology 5Reportlinker Adds Healthcare Information Technology 6Reportlinker Adds Healthcare Information Technology 7Reportlinker Adds Healthcare Information Technology 8Reportlinker Adds Healthcare Information Technology 9Reportlinker Adds Healthcare Information Technology 10Reportlinker Adds Healthcare Information Technology 11New approaches, technological advances offer promise for obesity treatment 2
... industry's first siRNA sequence design software in ... these tools consistent with new experimental strategies ... of RNAi. With the introduction of ... tools, OligoEngine is pleased to offer the ...
... perform many sophisticated DNA analysis and protein analysis ... just another sequence analysis product. Imagine having the ... to be performed each time you have a ... which specify exactly how your output will look ...
... Western Blot Signal Enhancer does for enzyme-/substrate-based blotting ... it increases the signal up to 10-fold (or ... ,The Western Blot Signal Enhancer membrane treatment ... added to your current Western blotting protocol. ...
These stopping screens are for the biolistic PDS-1000 He and Hepta systems. Supplied as 500 screens....
Biology Products: