Navigation Links
Researchers 'grow Rett syndrome' in a Petri dish
Date:11/15/2010

(Cincinnati, OH) A groundbreaking study published Friday in the leading scientific journal, Cell, revealed that a team of investigators had successfully generated nerve cells using skin cells from four individuals with Rett syndrome. The study, funded in part by IRSF, was led by Dr. Alysson Muotri at the University of California, San Diego--a leading researcher in the stem cell field.

The article, titled 'A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells,' describes how the team used a newly-devised procedure to reprogram the skins cells - literally winding back their developmental clock to an earlier state and transforming them into stem cells. The researchers then employed a second novel technique, taking the newly-formed stem cells and driving them along a developmental path to form nerve cells. When Dr. Muotri and his team examined these new nerve cells closely, they observed characteristic hallmarks of nerve cells with Rett syndrome, including fewer synapses, smaller cell bodies and changes in the cells' signaling capabilities. The group then took their work a step further; testing several drugs previously shown to be effective in mouse models of Rett syndrome, they provided evidence of functional rescue, using human cells. In 1999, the laboratory of Dr. Huda Zoghbi at Baylor College of Medicine, made a seminal discovery, identifying a causative link between mutations in the gene methyl-CpG-binding protein 2 (MeCP2) and Rett syndrome. This led to further work showing the MeCP2 protein is critical for the proper functioning of nerve cells. In 2007 another study in the laboratory of Dr. Adrian Bird at the University of Edinburgh, Scotland showed that restoration of MeCP2 function in a mouse model of the disease reverses the neurological symptoms in adult mice. This finding provided a critical proof of concept that symptoms of the disorder may be reversible in humans. However, t
'/>"/>

Contact: Stephen Bajardi
917-267-4503
International Rett Syndrome Foundation
Source:Eurekalert

Page: 1 2

Related biology news :

1. U of A researchers can predict heart transplant patients health earlier
2. UCLA researchers discover a potential target for therapy for patients with a deadly prostate cancer
3. Jefferson researchers receive W.W. Smith Charitable Trust
4. Studying the metabolome of smokers, Lombardi researchers find early signs of damage
5. Johns Hopkins researchers reshape basic understanding of cell division
6. Researchers unlock the secret of bacterias immune system
7. Missouri Botanical Garden researchers discover 8 new species in Boliva national parks
8. University of Illinois researchers discover potential new virus in switchgrass
9. NYU Courant researchers develop algebraic model to monitor cellular change
10. Researchers developing real-time electronic monitoring for coastal waters
11. Researchers could use plants light switch to control cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/7/2015)... Sweden , May 7, 2015 ... touch fingerprint sensors, FPC1022 and FPC1035, FPC,s smallest ... and FPC1035 are mainly considered for integration on ... size gives smartphone OEMs increased possibilities to integrate ... The decreased size also improves possibilities for module ...
(Date:4/27/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... the growing mobile commerce market, announces that its Wocket® ... first week of May, 2015 and will be fulfilling ... Gino Pereira , Chief Executive Officer ... as Wocket® enters the consumer market. We would like ...
(Date:4/20/2015)... -- The announcement comes as demand for ... (GRM), Ireland,s foremost records management company, ... up an impressive track record of clients within the first ... records management sector in Dubai . As ... and employ a further eight staff members at its Irish ...
Breaking Biology News(10 mins):FPC Introduces its Smallest Touch Fingerprint Sensors to Date 2Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 2Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 3Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 2Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 3
... A report published today concludes that the African lion is ... African lion once ranged continuously from Senegal to Nigeria, but ... 250 adult lions restricted to four isolated and severely imperiled ... lions. Led by Panthera,s Lion Program Survey ...
... the Fukushima 1 Nuclear Power Plant in 2011, Japanese plant ... contamination on wild and cultivated plants. In a special issue ... examine the potential adverse effects of radioactivity on nature and ... on the efforts of a research group led by Yoshihiro ...
... Tobacco smoking by pregnant women has long been ... adverse effects on the development of a fetus. ... outcomes, including low birth weight, sudden infant death syndrome, ... and nicotine use in offspring. Despite this extensive literature, ...
Cached Biology News:Lions are critically endangered in West Africa 2Lions are critically endangered in West Africa 3Microalgae and aquatic plants can help to decrease radiopollution in the Fukushima area 2Maternal stress hormones and maternal smoking increase daughter's risk of nicotine dependence 2
(Date:5/21/2015)... - SQI Diagnostics Inc. ("SQI" or the "Company") (TSX-V: ... commercializes proprietary technologies and products for advanced microarray diagnostics, ... second fiscal quarter ended March 31, 2015. ... business with our existing customers and to develop new ... of SQI. "The delivery of a fully automated sqidlite™ ...
(Date:5/21/2015)... 2015 Specialty Pharmacy Times has ... admitted to BPA Worldwide as a business publication ... audience data for Specialty Pharmacy Times based on ... becoming a member of BPA Worldwide, Specialty Pharmacy ... clients with the most reliable, unequaled data,” said ...
(Date:5/21/2015)... 21, 2015  Prima Biomed Ltd. (NASDAQ: PBMD ... to become a leader in the development of immunotherapeutic ... the final CVac data from the Phase II CAN-003 ... for a clinically meaningful improvement in Overall Survival ("OS") ... In the group of second remission patients ...
(Date:5/21/2015)... , May 21, 2015  The EveryLife ... Hatch (R-UT) and Amy Klobuchar ... Now Accelerating Cures & Treatments, or OPEN ACT. ... disease patient advocacy organizations, this bipartisan legislation promises ... affordable medicines to rare disease patients by incentivizing ...
Breaking Biology Technology:SQI Diagnostics Reports Second Quarter Financial Results 2SQI Diagnostics Reports Second Quarter Financial Results 3SQI Diagnostics Reports Second Quarter Financial Results 4SQI Diagnostics Reports Second Quarter Financial Results 5SQI Diagnostics Reports Second Quarter Financial Results 6SQI Diagnostics Reports Second Quarter Financial Results 7SQI Diagnostics Reports Second Quarter Financial Results 8Specialty Pharmacy Times Joins BPA Worldwide 2Correction Continues after Big Move - BrokerBank Securities, Inc. 2Advocates Cheer Senate Leaders for Introducing Bipartisan Bill to Increase Number of Rare Disease Treatments 2
... 10 Thoratec,Corporation (Nasdaq: THOR ), a ... today that it will be participating in the,Bear ... Gary Burbach, president and chief executive officer, ... 3 p.m., Eastern Daylight Time (12 p.m.,Pacific Daylight ...
... civil settlement with the U.S. Department of Justice ... federal False Claims Act,relating to Anzemet(R) involving one ... The settlement relates to government claims that API ... increased the cost of,government reimbursements for the drug. ...
... Inc. (Pink,Sheets: BMXSF), is pleased to announce ... Agricultural Developments Pty. Ltd. (http://www.scadev.net ) ... renewable bio-fuels,waste water management and related renewable ... is developing large vertical,integrated Agri-Energy plants worldwide. ...
Cached Biology Technology:Biomaxx Systems Inc. Selected as Technical Consultant By Southern Cross Agricultural Developments 2
Fast, sensitive quantitation of Mouse IgM concentration....
Request Info...
... anti-rabbit IgG FITC is used as ... staining on tissues or culture cells ... in rabbits. It is highly recommended ... omitting the primary antibody, be included ...
1000X solution used for inducing CopyControl™ based vectors to high copy numbers...
Biology Products: