Navigation Links
Researchers get close-up view of water pores needed in the eye's lens
Date:8/5/2013

Researchers have achieved dynamic, atomic-scale views of a protein needed to maintain the transparency of the lens in the human eye. The work, funded in part by the National Institutes of Health, could lead to new insights and drugs for treating cataract and a variety of other health conditions.

Aquaporin proteins form water channels between cells and are found in many tissues, but aquaporin zero (AQP0) is found only in the mammalian lens, which focuses light onto the retina, at the back of the eye. The lens is primarily made up of unique cells called lens fibers that contain little else besides water and proteins called crystallins. Tight packing of these fibers and of the crystallin proteins within them helps create a uniform medium that allows light to pass through the lens, almost as if it were glass.

Abnormal development or age-related changes in the lens can lead to cataracta clouding of the lens that causes vision loss. Besides age, other risk factors for cataract include smoking, diabetes, and genetic factors. Mutations in the AQP0 gene can cause congenital cataract and may increase the risk of age-related cataract.

"The AQP0 channel is believed to play a vital role in maintaining the transparency of the lens and in regulating water volume in the lens fibers, so understanding the molecular details of how water flows through the channel could lead to a better understanding of cataract," said Dr. Houmam Araj, who oversees programs on lens, cataract and oculomotor systems at NIH's National Eye Institute (NEI), which helped fund the research.

Closing of AQP0 channels is regulated by a calcium-sensitive protein called calmodulin, but the precise mechanism has been unclear. Some models have suggested that calmodulin simply acts as a plug to fill the open channel. The new study, published in Nature Structural and Molecular Biology, reveals a more nuanced process in which calmodulin essentially grasps the open channe
'/>"/>

Contact: Jean Horrigan
neinews@nei.nih.gov
301-496-5248
NIH/National Eye Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Practice makes the brains motor cortex more efficient, Pitt researchers say
2. MIT researchers reveal how the brain keeps eyes on the prize
3. Mount Sinai researchers develop first successful laboratory model for studying hepatitis C
4. Montana State University researchers highlight bears use of Banff highway crossings
5. HudsonAlpha and UAB researchers work to identify optimal treatments for ER+ breast cancer
6. UPCI researchers target cell sleep to lower chances of cancer recurrence
7. U-M researchers land $2M grant to cooperate with nature on growing algae for energy
8. UT Southwestern researchers identify novel mechanism that helps stomach bug cause illness
9. Researchers uncover cellular mechanisms for attention in the brain
10. Notre Dame researchers develop system that uses a big data approach to personalized healthcare
11. U of M researchers unveil nations first porcine virus rapid detection test
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... America (ESA) has elected ten new Fellows of the ... outstanding contributions to entomology in one or more of ... Fellows will be recognized during Entomology 2014 -- ESA,s ... 16-19, 2014 in Portland, Oregon. , DR. NILSA ... of Plant, Soil and Entomological Sciences at the University ...
(Date:7/30/2014)... DURHAM, N.C. -- A study of dominance in female baboons ... maintain close ties with mom, and to have lots of ... not by size or strength, but by the rank of ... higher-ranked her daughter will be. For this reason, dominance rank ... Females born to high-ranking mothers are guaranteed a good spot ...
(Date:7/30/2014)... 30, 2014 ResearchMoz presents ... Biometric Systems Market 2014-2024   Business Strategies, Industry Trends, ... Systems Market 2014-2024" offers the reader detailed analysis ... next ten years, alongside potential market opportunities to ... To view the table of contents ...
Breaking Biology News(10 mins):Entomological Society of America recognizes 2014 fellows 2Entomological Society of America recognizes 2014 fellows 3Entomological Society of America recognizes 2014 fellows 4Entomological Society of America recognizes 2014 fellows 5Entomological Society of America recognizes 2014 fellows 6Entomological Society of America recognizes 2014 fellows 7Entomological Society of America recognizes 2014 fellows 8Entomological Society of America recognizes 2014 fellows 9Entomological Society of America recognizes 2014 fellows 10Entomological Society of America recognizes 2014 fellows 11Entomological Society of America recognizes 2014 fellows 12Entomological Society of America recognizes 2014 fellows 13Entomological Society of America recognizes 2014 fellows 14Entomological Society of America recognizes 2014 fellows 15Entomological Society of America recognizes 2014 fellows 16Entomological Society of America recognizes 2014 fellows 17Supportive moms and sisters boost female baboon's rank 2Supportive moms and sisters boost female baboon's rank 3Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 2Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 3Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 4Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 5Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 6Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 7Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 8Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 9Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 10
... Pacific Branch of the Entomological Society of America (ESA) ... symposium in Waikoloa, Hawaii on the coffee berry borer, ... was recently discovered in the Kona District of Hawaii. ... 2010 to find ways of controlling this pest and ...
... DALLAS March 1, 2011 Researchers at UT Southwestern ... that,s sufficient to induce cellular leptin resistance, a problem that ... and should stop eating. "Leptin resistance is a ... unclear," said Dr. Joel Elmquist, professor of internal medicine and ...
... shape of the protein that gives human tissues their ... of new synthetic elastic polymers. University of Manchester ... States, used state-of-the-art techniques to reveal the structure of ... tissues in humans and other mammals to stretch, for ...
Cached Biology News:Coffee berry borer in Hawaii and prospects for control 2Signaling path in brain may prevent that 'I'm full' message, UT Southwestern scientists discover 2Solving the riddle of nature's perfect spring 2
(Date:7/31/2014)... Rancho BioSciences , the scientific ... Array Suite with tranSMART . Scientists that ... send data in tranSMART to Array Suite for further ... tranSMART including the new 1.2 release. Array Suite ... for the analysis of high dimensional quantification data, including ...
(Date:7/31/2014)... (PRWEB) July 31, 2014 ... and collaboration company, is proud to announce the ... LMS complements Adobe Connect’s elearning tools to quickly ... delivers content with training tools for desktop and ... with LMS is the perfect online training solution, ...
(Date:7/30/2014)... TARRYTOWN, N.Y. and PARIS ... REGN) and Sanofi (EURONEXT: SAN and NYSE: SNY) today ... Food and Drug Administration (FDA) rare pediatric disease priority ... (BLA) submission for alirocumab.  The priority review voucher entitles ... which provides for an expedited 6-month review from the ...
(Date:7/30/2014)... -- Replikins Ltd. today released new data on changes in ... current outbreaks, the mean Ebola Reston gene Replikin Count ... and 2002 was 1.1; the mean Replikin Count increased ... 2013, thus predicting the current outbreaks in humans. ... to be able to predict outbreaks (1).  For example, ...
Breaking Biology Technology:Rancho BioSciences, in Partnership with Omicsoft, have Integrated Array Suite with tranSMART 2Rancho BioSciences, in Partnership with Omicsoft, have Integrated Array Suite with tranSMART 3SoundConnect Enhances Portfolio with Adobe Connect Learning Management System (LMS) 2Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 2Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 3Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 4Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 5Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 6
... , CINCINNATI , Feb. 11 Kendle (Nasdaq: ... and full-year 2009 financial results after the market closes on Wednesday, ... and simultaneous webcast on Thursday, Feb. 25 at 8:00 ... Conference Call Instructions , To participate in the telephone ...
... ON , Feb. 11 /PRNewswire-FirstCall/ - YM BioSciences Inc. ... small molecule (CYT387) and on its novel vascular disrupting agent (CYT997) ... Australia . CYT387 is an oral JAK1/2 inhibitor, originating from the ... Wilks , the founder of Cytopia Limited, now YM Australia. CYT997 ...
... , Feb. 11 Advanced Cell Technology, Inc. ... obtained from induced pluripotent stem (iPS) cells exhibit abnormal expansion ... print) in the journal STEM CELLS by ACT ... School , and the University of Illinois , compares ...
Cached Biology Technology:Kendle Announces Details Regarding Fourth Quarter and Full-Year 2009 Earnings Conference Call and Webcast 2Kendle Announces Details Regarding Fourth Quarter and Full-Year 2009 Earnings Conference Call and Webcast 3YM BioSciences presents CYT387 and CYT997 data at international cancer conference 2YM BioSciences presents CYT387 and CYT997 data at international cancer conference 3YM BioSciences presents CYT387 and CYT997 data at international cancer conference 4Therapeutic Cells Derived From Reprogrammed (iPS) Stem Cells Display Early Aging 2Therapeutic Cells Derived From Reprogrammed (iPS) Stem Cells Display Early Aging 3Therapeutic Cells Derived From Reprogrammed (iPS) Stem Cells Display Early Aging 4
...
MOUSE ANTI PORCINE SLA 1:FITC Immunogen: Porcine peripheral blood mononuclear cells....
This antibody detects an ~92 kDa protein corresponding to the apparent molecular mass of the beta subunit of Hypoxia Inducible Factor-1 (HIF-1beta) on Western blots....
...
Biology Products: