Navigation Links
Researchers get a first look at the mechanics of membrane proteins
Date:4/17/2011

CHAMPAIGN, Ill. In two new studies, researchers provide the first detailed view of the elaborate chemical and mechanical interactions that allow the ribosome the cell's protein-building machinery to insert a growing protein into the cellular membrane.

The first study, in Nature Structural and Molecular Biology, gives an atom-by-atom snapshot of a pivotal stage in the insertion process: the moment just after the ribosome docks to a channel in the membrane and the newly forming protein winds its way into the membrane where it will reside.

A collaboration between computational theoretical scientists at the University of Illinois and experimental scientists at University of Munich made this work possible. Using cryo-electron microscopy to image one moment in the insertion process, the researchers in Munich were able to get a rough picture of how the many individual players the ribosome, membrane, membrane channel and newly forming protein come together to get the job done. Each of these structures had been analyzed individually, but no previous studies had succeeded in imaging all of their interactions at once.

"The computational methodology contributed by the Illinois group was crucial in interpreting the new cryo-EM reconstruction in terms of an atomic level structure, and testing the interpretation through simulation," said co-author Roland Beckmann at the University of Munich. "Our joint study is unique in so closely and successfully combining experimental and computational approaches."

To image the ribosome's interaction with the membrane, Beckmann's team used small disks of membrane held together with belts of engineered lipoproteins. University of Illinois biochemistry professor Stephen Sligar developed and pioneered the use of these "nanodiscs."

The Illinois team used the cryo-EM images as well as detailed structural information about the ribosome and other molecules to construct an atom-by-atom mod
'/>"/>

Contact: Diana Yates
diya@illinois.edu
217-244-1073
University of Illinois at Urbana-Champaign
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Jefferson researchers unlock key to personalized cancer medicine using tumor metabolism
2. NIH researchers complete whole-exome sequencing of skin cancer
3. New genetic tool helps researchers to analyze cells most important functions
4. NIH researchers identify cause and new treatment for common recurrent fever in children
5. UMMS researchers develop new technology to screen and analyze genetic mutations
6. Livermore researchers develop battery-less chemical detector
7. Researchers ID microbe responsible for methane from landfills
8. Researchers identify new role for cilia protein in mitosis
9. Researchers link herpes to Alzheimers disease
10. Researchers say children need horticultural interventions
11. Berkeley Lab researchers make first perovskite-based superlens for the infrared
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers get a first look at the mechanics of membrane proteins
(Date:3/24/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/hdgz7h/global_iris ... Iris Recognition Market 2015-2019" report to their offering. ... market to grow at a CAGR of 23.5 percent ... the present scenario and the growth prospects of the ... calculate the market size, the report considers the revenue ...
(Date:3/24/2015)... BEACH GARDENS, Fla. , March 24, 2015 ... biometric identity management solutions, today announced that its ... premium clothing accessory retailer Goorin Bros . ... The Crossmatch biometrics-based solution secures access to the ... from the increased risk of data breaches. ...
(Date:3/23/2015)... LOS ANGELES , March 23, 2015  In ... in Federal fraud case conviction losses. This figure accounts ... fraud, which, according to The Nilson Report, exceeds $11 ... an investigative tool after a crime has occurred. Investor ... Agent and polygraph expert Joe Paolella partnered ...
Breaking Biology News(10 mins):Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2Polygraph Test Now Used to Protect Investors From Fraud 2Polygraph Test Now Used to Protect Investors From Fraud 3
... Assistant Professor Frank J. Slack at Yale University has identified ... lung cancer, presenting new possibilities for diagnosis and treatment. The ... and Developmental Cell. , The oncogene Ras is out of ... over-expressed or activated by mutation. According to Slack, a member ...
... at the Marine Biological,Laboratory (MBL) has published ... that supports her hypothesis that, when combined, ... as BCE--can act synergistically to alter a ... have previously studied the effects,of these pollutants ...
... a longtime University of Chicago collaborator, Goldstein conducted an experiment ... these skinny, graceful fish can swim from salt water to ... prompt an equally drastic physiological change: Our cells would take ... and rapidly causing death. So how do skates do it? ...
Cached Biology News:Yale Scientists Find MicroRNA Regulates Ras Cancer Gene 2Clam embryo study shows pollutant mixture adversely affects nerve cell development 2Clam embryo study shows pollutant mixture adversely affects nerve cell development 3Sea skate experiment sheds light on human cell transport 2
(Date:4/21/2015)... 2015  This research service analyzes the various PEVC ... biotechnology industry. The deals are analyzed based on their ... on the geographic region and buyer types. The study ... into account various deal multiples such as enterprise value, ... company. Executive Summary Key ...
(Date:4/21/2015)... April 21, 2015 The North American chromatography systems ... from 2014 to 2019. Based on geography, this market has ... and Mexico . The U.S. accounted for ... . The major factors driving the growth of chromatography systems ... industries are the prime users of chromatography techniques. ...
(Date:4/21/2015)... and Markets ( http://www.researchandmarkets.com/research/z24n33/global ) has announced ... 2019" report to their offering. The ... 3.7 Billion in 2013 with the anticipation of its ... The report is an outcome of an ... opportunities listed in the section of the bioinformatics trends. ...
(Date:4/21/2015)... 2015 Research and Markets ( ... "Complete 2015-16 Induced Pluripotent Stem Cell (iPSC) ... Stem cell research and experimentation have been ... stem cells have the unique ability to divide ... allows them to differentiate into a wide variety ...
Breaking Biology Technology:Funding Patterns in the Global Pharma and Biotech Industry 2North American Chromatography systems Market by Types, & by End-Users - Forecast to 2019 2North American Chromatography systems Market by Types, & by End-Users - Forecast to 2019 3Global Bioinformatics Market Outlook Report 2014-2019 - The US$ 3.7 Billion Market is Expected to Grow at a CAGR of 19% during 2015-2019 2Global Bioinformatics Market Outlook Report 2014-2019 - The US$ 3.7 Billion Market is Expected to Grow at a CAGR of 19% during 2015-2019 3Global Complete 2015-16 Induced Pluripotent Stem Cell (iPSC) Industry Report 2
... power they use. The more power they use, the hotter ... overheat. It doesn,t take a rocket scientist to understand what ... of electronics, thermal control is always one of the limiting ... to help cool down electronic components. However, Jeffrey ...
... BioStorage Technologies, the premier global provider of ... has opened its new state-of-the-art biorepository facility in ... company,s strategic growth plan, and represents a 4.6MM ... near the second largest FedEx hub in the ...
... 2011 Reportlinker.com announces that a new ... catalogue: Future Directions in ... Big Pharma has begun ... Pfizer and Novartis in 2009, and Cephalon ...
Cached Biology Technology:NASA is making hot, way cool 2NASA is making hot, way cool 3BioStorage Technologies Expands U.S. Operations with Opening of New Biorepository Facility 2BioStorage Technologies Expands U.S. Operations with Opening of New Biorepository Facility 3Reportlinker Adds Future Directions in Regenerative Medicine 2Reportlinker Adds Future Directions in Regenerative Medicine 3Reportlinker Adds Future Directions in Regenerative Medicine 4Reportlinker Adds Future Directions in Regenerative Medicine 5Reportlinker Adds Future Directions in Regenerative Medicine 6
PURA Immunogen: PURA (NP_005850, 183 a.a. ~ 293 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
Rabbit polyclonal to CAMK 1D beta ( Abpromise for all tested applications). entrezGeneID: 57118 SwissProtID: Q5SQQ7...
Acetyl-Histone H2B (Lys20) Antibody...
...
Biology Products: