Navigation Links
Researchers get a first look at the mechanics of membrane proteins
Date:4/17/2011

CHAMPAIGN, Ill. In two new studies, researchers provide the first detailed view of the elaborate chemical and mechanical interactions that allow the ribosome the cell's protein-building machinery to insert a growing protein into the cellular membrane.

The first study, in Nature Structural and Molecular Biology, gives an atom-by-atom snapshot of a pivotal stage in the insertion process: the moment just after the ribosome docks to a channel in the membrane and the newly forming protein winds its way into the membrane where it will reside.

A collaboration between computational theoretical scientists at the University of Illinois and experimental scientists at University of Munich made this work possible. Using cryo-electron microscopy to image one moment in the insertion process, the researchers in Munich were able to get a rough picture of how the many individual players the ribosome, membrane, membrane channel and newly forming protein come together to get the job done. Each of these structures had been analyzed individually, but no previous studies had succeeded in imaging all of their interactions at once.

"The computational methodology contributed by the Illinois group was crucial in interpreting the new cryo-EM reconstruction in terms of an atomic level structure, and testing the interpretation through simulation," said co-author Roland Beckmann at the University of Munich. "Our joint study is unique in so closely and successfully combining experimental and computational approaches."

To image the ribosome's interaction with the membrane, Beckmann's team used small disks of membrane held together with belts of engineered lipoproteins. University of Illinois biochemistry professor Stephen Sligar developed and pioneered the use of these "nanodiscs."

The Illinois team used the cryo-EM images as well as detailed structural information about the ribosome and other molecules to construct an atom-by-atom mod
'/>"/>

Contact: Diana Yates
diya@illinois.edu
217-244-1073
University of Illinois at Urbana-Champaign
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Jefferson researchers unlock key to personalized cancer medicine using tumor metabolism
2. NIH researchers complete whole-exome sequencing of skin cancer
3. New genetic tool helps researchers to analyze cells most important functions
4. NIH researchers identify cause and new treatment for common recurrent fever in children
5. UMMS researchers develop new technology to screen and analyze genetic mutations
6. Livermore researchers develop battery-less chemical detector
7. Researchers ID microbe responsible for methane from landfills
8. Researchers identify new role for cilia protein in mitosis
9. Researchers link herpes to Alzheimers disease
10. Researchers say children need horticultural interventions
11. Berkeley Lab researchers make first perovskite-based superlens for the infrared
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers get a first look at the mechanics of membrane proteins
(Date:7/28/2014)... wild relative of the domestic tomato, has been published ... headed by Professors Neelima Sinha and Julin Maloof at ... genome information may help breeders produce tastier, more stress-tolerant ... journal Nature Genetics , was lead by Bjrn ... UC Davis labs carried out work on the transcriptome ...
(Date:7/28/2014)... no cure for Alzheimer,s disease and other forms of ... to finding treatment. , University of Washington bioengineers have ... harmful changes of the body,s normal proteins into a ... Parkinson,s, heart disease, Type 2 diabetes and Lou Gehrig,s ... shift from their normal state into an abnormally folded ...
(Date:7/28/2014)... New research has identified areas of the Earth that ... climate change. , Europe is particularly vulnerable, as it ... four per cent, of any continent in ,refugia, ... natural environmental conditions remain relatively constant during times of ... Europe are mostly in Scandinavia and Scotland. , ...
Breaking Biology News(10 mins):New protein structure could help treat Alzheimer's, related diseases 2New protein structure could help treat Alzheimer's, related diseases 3Study finds Europe's habitat and wildlife is vulnerable to climate change 2
... show a combination of depressive symptoms and elevated levels of ... likely to develop major depression than those who show neither ... In a study published today in the Proceedings ... University of Cambridge have identified the first biomarker a ...
... non-coding RNAs can be used to predict if individuals ... Cancer Genome Atlas project. The results, which are published ... the levels of specific types of non-coding RNAs can ... These RNAs can also be used to classify cancer ...
... cancers so difficult to treat is that malignant cells from ... and blood vessels to invade new locations. Now, researchers have ... cancer by using a film of nanofibers thinner than human ... invading new areas, the migrating cells latch onto the specially-designed ...
Cached Biology News:First biological marker for major depression could enable better diagnosis and treatment 2First biological marker for major depression could enable better diagnosis and treatment 3First biological marker for major depression could enable better diagnosis and treatment 4Small non-coding RNAs could be warning signs of cancer 2Researchers hijack cancer migration mechanism to 'move' brain tumors 2Researchers hijack cancer migration mechanism to 'move' brain tumors 3Researchers hijack cancer migration mechanism to 'move' brain tumors 4
(Date:7/25/2014)... July 25, 2014 According to a ... Drugs Market - Global Industry Analysis, Size, Share, Growth, ... drugs market is estimated at USD 161,056.5 million in ... of 10.1% from 2014 to 2020, to reach an ... The biological drugs market is witnessing a significant growth ...
(Date:7/25/2014)... 25, 2014 The Conferee Networking committee ... for Conferee Networking. These two-hour sessions provide a unique ... and resolve problems, discuss new techniques, or brainstorm new ... submit a topic for consideration is August 31, 2014, ... The Conferee Networking committee will review the topics, and ...
(Date:7/25/2014)... AVIV, Israel , July 25, 2014  Galmed ... clinical-stage biopharmaceutical company focused on the development and commercialization ... liver diseases and cholesterol gallstones, today announced financial results ... First Half 2014 Financial Summary: , Reported cash ... 2014, compared with $137,000 at December 31, 2013.  ...
(Date:7/25/2014)... July 25, 2014 At the request ... granted a 60-day extension for the public comment period ... Rule for Model Aircraft established by Congress as part ... The 60-day extension establishes the new deadline for comments ... Department of Transportation/FAA notice published in the Federal Register ...
Breaking Biology Technology:Biological Drugs Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 2Biological Drugs Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 3Pittcon 2015 Announces Call for Topics for Conferee Networking Sessions 2Galmed Pharmaceuticals Reports First Half 2014 Financial Results 2Galmed Pharmaceuticals Reports First Half 2014 Financial Results 3Galmed Pharmaceuticals Reports First Half 2014 Financial Results 4Galmed Pharmaceuticals Reports First Half 2014 Financial Results 5Galmed Pharmaceuticals Reports First Half 2014 Financial Results 6FAA Grants Comment Extension at the Request of AMA 2
... Oct. 7 Sydney-based Clinical Genomics Pty Ltd and ... collaboration to develop improved diagnostics for cancers of the ... research program, Clinical Genomics and researchers from CSIRO,s Preventative ... a number of biomarker genes capable of differentiating between ...
... ... Mass., and Applied CleanTech, based in Israel, today announced that they ... agricultural liquid waste into ethanol fuel for cars. Joint use of ... found to boost ethanol production, address sewage sludge disposal problems, and ...
... Pa., Oct. 6 Isolagen, Inc. has reorganized ... (OTC Bulletin Board: FCSC), a biotechnology company focused ... and scientific applications. The Company has named a ... Administration (FDA) is currently reviewing the biologics license ...
Cached Biology Technology:Clinical Genomics Continues Collaborative Research With CSIRO 2Cellulose from Wastewater Can Now be Turned into Fuel for Cars 2Cellulose from Wastewater Can Now be Turned into Fuel for Cars 3Cellulose from Wastewater Can Now be Turned into Fuel for Cars 4Isolagen, Inc. Reorganizes as Fibrocell Science, Inc. 2Isolagen, Inc. Reorganizes as Fibrocell Science, Inc. 3Isolagen, Inc. Reorganizes as Fibrocell Science, Inc. 4
Troponin I (22B11)...
... low temperature freezers offer a superior ... of biological samples with high capacities. ... inner doors ensure excellent warming protection ... ,Application oriented accessories simplify tracking of ...
Chicken polyclonal to UCK2 ( Abpromise for all tested applications). Antigen: Full length protein, corresponding to amino acids 1-261 of Human UCK2 Entrez Gene ID: 7371 Swiss Protein ID: ...
Thermo Labsystems offers a basic reader for 96-well microplates that is especially adapted for ELISA and other colorimetric assays....
Biology Products: