Navigation Links
Researchers get $7.5M grant to combat nerve agents
Date:11/14/2011

A $7.5 million award will help researchers harness the body's own defenses to counteract nerve agents and create new types of antidotes for exposure to pesticides and other poisons.

The grant, from the National Institutes of Health (NIH), extends a previous grant and establishes a new Center of Excellence at Ohio State University, where chemists will collaborate with the U.S. Army Medical Research Institute of Chemical Defense (USAMRICD) at Aberdeen Proving Ground, Md., and the Weizmann Institute of Science in Israel.

At the new Ohio State center, chemists Thomas J. Magliery and Christopher M. Hadad will lead a team that employs sophisticated methods of protein engineering, high-throughput screening and computational chemistry at the university and the Ohio Supercomputer Center (OSC). Their goal is to improve enzymes' ability to destroy a broad array of chemical agents inside the body.

Magliery is an assistant professor of chemistry and biochemistry, and Hadad is a professor of chemistry and associate dean in the Division of Natural and Mathematical Sciences of the College of Arts and Sciences at Ohio State.

"Dr. Hadad's research group is consistently one of the largest and most sophisticated user groups of computing cycles at the center," said Ashok Krishnamurthy, interim co-executive director of OSC. "It is gratifying for OSC to provide him with the resources that helped formalize such an important collaboration. Hopefully, it will lead to significant steps toward counteracting these toxic agents."

Nerve agents are chemicals that attack the nervous system, causing paralysis and seizures and ultimately killing the victim through asphyxiation. They do so by bonding with the enzyme acetylcholinesterase so that it can't transmit chemical messages from the brain to the rest of the body.

Once attached to the enzyme, nerve agents can't be removed, explained Magliery. So the researchers are focusing on ways to stop the deadly chemicals before they can attach in the first place. They have engineered souped-up versions of naturally occurring human enzymes that will scavenge nerve agents from the bloodstream. No tests involving actual nerve agents will take place at Ohio State.

"Nerve agents like sarin, and even related pesticides, are a significant threat in the hands of terrorists, and we're really lacking in ways to treat mass casualties," said Magliery, co-leader of the new Ohio State center. "Fortunately, there are enzymes already in human blood that can deactivate these agents. We just have to engineer them to be more efficient, and we have to be able to produce and formulate them as drugs."

Hadad leads an effort to model the chemical structure of candidate enzymes on the powerful parallel supercomputer systems at OSC, while Magliery is producing synthetic versions of the new enzymes for further testing and preclinical evaluation by the Army.

"The preliminary results from the first round of this grant showed that these enzymes can be engineered to have enough activity to use as therapeutic agents," said Magliery. "But there are still challenges ahead. There are a lot of related agents, and there are few enzymes used as drugs today."

Hadad outlined one of the main challenges. "In nature, each enzyme generally has only one function one thing that it does very well," he said. "But we need an enzyme that will deactivate many different nerve agents.

"We need one molecule that can do it all."

Magliery added that the ideal enzyme would remain active for days or weeks at a time, pulling toxic agents from the body over and over again. It could be administered as an antidote immediately after an attack, or as an inoculation against future attacks.

Soldiers and first responders are among the likely recipients of such a preventive dose, but so are people whose jobs regularly expose them to nerve agents, even in small quantities. For instance, 300,000 American farm workers suffer pesticide poisoning each year, according to the U.S. Environmental Protection Agency. Household pesticides pose the same dangers, so an enzymatic drug could save lives in poison control centers as well.


'/>"/>

Contact: Mr. Jamie Abel
jabel@osc.edu
614-292-6495
Ohio Supercomputer Center
Source:Eurekalert  

Related biology news :

1. Researchers uncover why the body cant defend against tuberculosis
2. Results triple researchers projections with use of adult stem cells for heart failure
3. Researchers develop more effective way to discover and test potential cancer drugs
4. Researchers closer to the super bug puzzle
5. Einstein researchers discover key to cell specialization
6. 200 thousand dollars awarded to genomics researchers to spark new research technology development
7. Becoming part of global, shoestring team requires researchers only to play fair, share
8. Pitt researchers develop eButton, an easier way to monitor food intake, exercise, and lifestyle
9. Berkeley Lab researchers create first of its kind gene map of sulfate-reducing bacterium
10. Do plants perform best with family or strangers? Researchers consider social interactions
11. University of Saskatchewan, Royal Ontario Museum researchers track half-billion year old predator
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers get $7.5M grant to combat nerve agents
(Date:5/6/2017)... RAM Group , Singaporean based ... in biometric authentication based on a novel  ... to perform biometric authentication. These new sensors are based on ... Ram Group and its partners. This sensor will have ... and security. Ram Group is a next generation ...
(Date:4/19/2017)... ALBANY, New York , April 19, 2017 /PRNewswire/ ... highly competitive, as its vendor landscape is marked by ... in the market is however held by five major ... and Safran. Together these companies accounted for nearly 61% ... majority of the leading companies in the global military ...
(Date:4/17/2017)... MELBOURNE, Florida , April 17, 2017 ... security technology company, announces the filing of its 2016 Annual Report ... Securities and Exchange Commission. ... Report on Form 10-K is available in the Investor Relations section ... well as on the SEC,s website at http://www.sec.gov . ...
Breaking Biology News(10 mins):
(Date:7/16/2017)... ... July 16, 2017 , ... OHAUS Corporation, a leading ... of its new line of Extreme Environment Shakers today. , Extreme Environment Shakers ... humidity for optimal cell growth such as cell cultures, solubility studies and extraction ...
(Date:7/14/2017)... ... July 14, 2017 , ... Sonic Manufacturing Technologies is ... has installed a solar system on its roof top. “We will be independent ... Sonic, Kenneth Raab stated. The company’s proud history of social responsibility and participation ...
(Date:7/14/2017)... ... July 13, 2017 , ... LGC Maine Standards ... US FDA 510 (k) clearance for use on Siemens Sysmex® CS-2500 System analyzers. ... D-Dimer kit, prepared using the CLSI EP06-A “equal delta” sample preparation, offers five ...
(Date:7/13/2017)... ... ... Thousands of pilots from across the country will visit the AMA’s International Aeromodeling ... Muncie to compete in various categories of model flying competition. Each pilot comes to ... , RC Pylon (July 14-21): One of the most fun competitions to watch! RC ...
Breaking Biology Technology: