Navigation Links
Researchers genetically link Lou Gehrig's disease in humans to dog disease
Date:1/21/2009

COLUMBIA, Mo. An incurable, paralyzing disease in humans is now genetically linked to a similar disease in dogs. Researchers from the University of Missouri and the Broad Institute have found that the genetic mutation responsible for degenerative myelopathy (DM) in dogs is the same mutation that causes amyotrophic lateral sclerosis (ALS), the human disease also known as Lou Gehrig's Disease. As a result of the discovery, which will be published in the Proceedings of the National Academy of Sciences this week, researchers can now use dogs with DM as animal models to help identify therapeutic interventions for curing the human disease, ALS.

"We uncovered the genetic mutation of degenerative myelopathy, which has been unknown for 30 years, and linked it to ALS, a human disease that has no cure," said Joan Coates, a veterinary neurologist and associate professor of veterinary medicine and surgery in the MU College of Veterinary Medicine. "Dogs with DM are likely to provide scientists with a more reliable animal model for ALS. Also, this discovery will pave the way for DNA tests that will aid dog breeders in avoiding DM in the future."

Previously, ALS research has relied heavily on transgenic rodents that expressed the mutant human gene SOD1, which causes ALS. Researchers found that dogs with DM also had mutations in their SOD1 gene. Many rodent models possess very high levels of the SOD1 protein that can produce pathologic processes distinct from those occurring in ALS patients. Since the SOD1 mutation is spontaneous in dogs, the clinical spectrum in dogs may represent more accurately that of human ALS.

"Compared with the rodent models for ALS, dogs with DM are more similar to people in size, structure and complexity of their nervous systems, and duration of the disease," said Gary Johnson, associate professor of veterinary pathobiology in the MU College of Veterinary Medicine. "The results from clinical trials conducted w
'/>"/>

Contact: Kelsey Jackson
JacksonKN@missouri.edu
573-882-8353
University of Missouri-Columbia
Source:Eurekalert

Page: 1 2

Related biology news :

1. Texas Medical Center researchers win collaborative grants
2. Researchers describe protease inhibitor that may aid in diabetic retinopathy treatment
3. Researchers examine developing hearts in chickens to find solutions for human heart abnormalities
4. JDRF-funded researchers discover proteins regulating human beta cell replication
5. Researchers to use K-States BSL-3 Lab for $1 million study of fungus threatening wheat crops
6. Researchers identify potential new weapon in battle against HIV infection
7. U-M researchers discover new genes that fuse in cancer
8. Researchers first to see reactive oxygen species in vital enzyme
9. Dartmouth researchers find new protein function
10. Burnham researchers discover on switch for cell death signaling mechanism
11. Salk researchers develop novel glioblastoma mouse model
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/20/2015)... DENVER , July 20, 2015  Acuity ... Mobility Report: The Convergence of Commerce and Privacy" ... billion mobile biometric apps will be downloaded to ... users. The mobile biometrics market is projected to ... app revenue during the seven-year forecast period.    ...
(Date:7/9/2015)... , July 9, 2015  Synaptics Inc. (NASDAQ: SYNA ... today that it will report financial results for the ... 30, 2015 after the close of market. The company ... investors at 2:00 p.m. PT (5:00 p.m. ET), during ... To participate on the live call, analysts and investors ...
(Date:7/9/2015)... JOSE, Calif. , July 9, 2015 ... the leading developer of human interface solutions, ... technology, the industry,s first fully hardware encapsulated ... Match-in-Sensor secure authentication technology is literally off ... storage and biometric matching within the fingerprint ...
Breaking Biology News(10 mins):Biometrics on Smart Mobile Devices to Redefine Digital Identity with 12.9 Billion Biometric App Downloads between 2014 and 2020 2Synaptics to Report Fourth Quarter, Fiscal Year 2015 Results on July 30 2Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 2Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 3
... an extracellular matrix (ECM) containing proteins such as collagen, ... in regulating cell function. ECM proteins bind to integrins ... regulate cellular morphology, adhesion, cell migration, cell proliferation, and ... field, Extracellular Matrix Biology covers all aspects ...
... The world may seem painted with endless color, but ... red, green, and blue. Now a Tel Aviv University-developed ... analyze the world we live in. With the ability to ... Mr. Spock,s sci-fi "Tricorder," is being used to "diagnose" contaminants ...
... Shenzhen, China - BGI, the world,s largest genomic organization, ... the superior performance of RNA-Seq in predicting patient outcomes ... launched by the U.S. Food and Drug Administration (FDA). ... phase of the MicroArray Quality Control (MAQC), aimed at ...
Cached Biology News:Thousand-color sensor reveals contaminants in Earth and sea 2BGI to play a pivotal role in demonstrating the superior performance of RNA-Seq 2
(Date:7/27/2015)... ... July 27, 2015 , ... Visual Assay was named as a finalist ... most innovative technologies and services of the past year. More than 70 judges selected ... The winners will be announced at the 2015 R&D 100 Awards Dinner on November ...
(Date:7/24/2015)... 24, 2015 Ryan & Maniskas, LLP ... States District Court for the Northern District of ... that purchased the common stock of Avalanche Biotechnologies, Inc. ("Avalanche" ... 2014 and June 15, 2015, inclusive (the "Class Period"). ... move the Court for appointment as a lead plaintiff of ...
(Date:7/24/2015)... -- Champions Oncology (OTC-BB: CSBR), a company engaged in the ... the development and use of oncology drugs, today announced ... the fourth quarter and fiscal year quarter ended April ... open. The company will host a conference ... a.m. EDT (6:00 a.m. PDT). To participate in the ...
(Date:7/24/2015)... 2015 The global next ... 27.8 billion by 2022, growing at an estimated CAGR ... new study by Grand View Research, Inc. Development of ... result in significant reduction in cost of sequencing one ... usage rates of next generation sequencing throughout the forecast ...
Breaking Biology Technology:Visual Assay® Named Finalist in 53rd Annual R&D 100 Awards 2Ryan & Maniskas, LLP Announces Class Action Lawsuit Against Avalanche Biotechnologies, Inc. 2Ryan & Maniskas, LLP Announces Class Action Lawsuit Against Avalanche Biotechnologies, Inc. 3Champions Oncology to Announce Fourth Quarter Financial Results on Tuesday, July 28 2Next Generation Sequencing (NGS) Market To Reach $27.8 Billion By 2022: Grand View Research, Inc. 2Next Generation Sequencing (NGS) Market To Reach $27.8 Billion By 2022: Grand View Research, Inc. 3Next Generation Sequencing (NGS) Market To Reach $27.8 Billion By 2022: Grand View Research, Inc. 4Next Generation Sequencing (NGS) Market To Reach $27.8 Billion By 2022: Grand View Research, Inc. 5
... A couple weeks ago, I asked, "Just what is this Web ... wide use of a phrase to label everything from start-ups ("Oh, ... site") to a point on the technology evolution timeline ("we're in ... question were almost as varied. , ,For Romasha Roy Choudhury ...
... - Merge Technologies, Inc. has received a written ... the company's failure to file financial reports for the quarter ... for delisting its common stock from NASDAQ. , ,Representatives ... before the NASDAQ Listing Qualifications Panel to request that the ...
... Milwaukee, Wis . - David Melbye hasn't been a ... has a significant information technology project under his belt. ... District , is wrapping up a major IT overhaul ... the district's governing commission. While he's pleased with the ...
Cached Biology Technology:Readers' Web 2.0 definitions 2Readers' Web 2.0 definitions 3Readers' Web 2.0 definitions 4CIO Leadership Series: David Melbye, Milwaukee Metro Sewerage District 2CIO Leadership Series: David Melbye, Milwaukee Metro Sewerage District 3CIO Leadership Series: David Melbye, Milwaukee Metro Sewerage District 4CIO Leadership Series: David Melbye, Milwaukee Metro Sewerage District 5
... microarrays are derived from frozen embedded tissue ... control procedures to ensure the highest quality. ... in one block, sectioned at a thickness ... Sections are large (3-5mm in diameter) in ...
... The DNA Engine Opticon real-time PCR ... LEDs for fluorescence excitation (450-495 nm) and ... nm). The Opticon system is built on ... includes a thermal gradient feature. This item ...
... Precision-designed for Optimal Microdissection , CapSure HS ... precise and rapid extraction of populations of ... samples with Laser Capture Microdissection., Ensure ... Molecular Analysis , All CapSure LCM Caps ...
... VersArray ChipReader systems are highly sensitive ... of microarrays. These are advanced scanners that ... response and background level, and optimizing the ... the top end of the range for ...
Biology Products: