Navigation Links
Researchers generate functional neurons from somatic cells

Los Angeles, Calif. February 24, 2009 In a new study, researchers were able to generate functionally mature motor neurons from induced pluripotent stem (iPS) cells, which are engineered from adult somatic cells and can differentiate into most other cell types. A potential new source of motor neurons that does not require human eggs or embryos could be an enormous boon to research into conditions such as amyotrophic lateral sclerosis (ALS) and spinal cord injury and could open the door to eventual treatments. The study is published in Stem Cells.

This study is the first to use human iPS cells to generate electrically active motor neurons, a key hallmark of functional maturation that is essential for any future application of iPS cells. "To our knowledge, our results present the first demonstration of the electrical activity of iPS-derived neurons and further suggest the feasibility of using these cells to explore how changes in motor neuron activity contributes to the degeneration of these cells underlying these disorders," the authors state.

Led by William Lowry, and in collaboration with Bennett Novitch, Harley Kornblum, and Martina Wiedau-Pazos of the University of California Los Angeles, researchers compared the ability of different human cell lines to generate motor neuron progenitors and fully differentiated motor neurons. "These findings support the possibility that reprogrammed somatic cells might prove to be a viable alternative to embryo-derived cells in regenerative medicine," the authors note.

When measuring the electrophysical properties of the iPS-derived neurons, the researchers found that the iPS cells followed a normal developmental progression to mature, electrically active neurons.

"It seems possible that disease-specific somatic cells may be reprogrammed and utilized to model, and ultimately to treat a variety of human neurological disorders," says Miodrag Stojković, co-editor of the journal.


Contact: Sean Wagner

Related biology news :

1. UNH researchers studying spiny dogfish, Gulf of Maines mini shark
2. UT Southwestern researchers identify molecule that helps the sleep-deprived to mentally rebound
3. Case Western Reserve researchers develop wireless activation of brain circuits
4. Caltech and UCSD researchers shed light on how proteins find their shapes
5. Researchers call for nitrogen and phosphorus reductions to combat eutrophication in aquatic systems
6. Researchers explore new driver of transplant rejection: Platelets
7. Forget the antioxidants? McGill researchers cast doubt on role of free radicals in aging
8. Researchers isolate protein domain linked to tumor progression
9. CSHL researchers identify gene that helps plant cells keep communication channels open
10. Researchers identify gene linked to aggressive progression of liver cancer
11. Case Western Reserve researchers looking at light-induced toxins in air and water
Post Your Comments:
(Date:4/6/2017)... Forecasts by Product Type (EAC), ... End-Use (Transportation & Logistics, Government & Public Sector, Utilities ... Generation Facility, Nuclear Power), Industrial, Retail, Business Organisation (BFSI), ... you looking for a definitive report on the $27.9bn ... ...
(Date:4/4/2017)... 4, 2017   EyeLock LLC , a leader ... United States Patent and Trademark Office (USPTO) has issued ... linking of an iris image with a face image ... the company,s 45 th issued patent. ... timely given the multi-modal biometric capabilities that have recently ...
(Date:3/30/2017)... YORK , March 30, 2017 Trends, ... type (physiological and behavioral), by technology (fingerprint, AFIS, iris ... voice recognition, and others), by end use industry (government ... and immigration, financial and banking, and others), and by ... Europe , Asia Pacific , ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... They call it the ... network, a depiction of a system of linkages and connections so complex and ... professor of computer science at Worcester Polytechnic Institute (WPI) and director of the ...
(Date:10/12/2017)... JOHNSTON, Iowa (PRWEB) , ... October 12, 2017 ... ... company based in Vilnius, Lithuania, announced today that they have entered into a ... collaboration is to provide CRISPR researchers with additional tools for gene editing across ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... Wound Market with the addition of its newest module, US Hemostats & Sealants. ... for thrombin hemostats, absorbable hemostats, fibrin sealants, synthetic sealants and biologic sealants used ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... launched Rosalindâ„¢, the first-ever genomics analysis platform specifically designed for life science ... in honor of pioneering researcher Rosalind Franklin, who made a major contribution ...
Breaking Biology Technology: