Navigation Links
Researchers generate functional neurons from somatic cells
Date:2/24/2009

Los Angeles, Calif. February 24, 2009 In a new study, researchers were able to generate functionally mature motor neurons from induced pluripotent stem (iPS) cells, which are engineered from adult somatic cells and can differentiate into most other cell types. A potential new source of motor neurons that does not require human eggs or embryos could be an enormous boon to research into conditions such as amyotrophic lateral sclerosis (ALS) and spinal cord injury and could open the door to eventual treatments. The study is published in Stem Cells.

This study is the first to use human iPS cells to generate electrically active motor neurons, a key hallmark of functional maturation that is essential for any future application of iPS cells. "To our knowledge, our results present the first demonstration of the electrical activity of iPS-derived neurons and further suggest the feasibility of using these cells to explore how changes in motor neuron activity contributes to the degeneration of these cells underlying these disorders," the authors state.

Led by William Lowry, and in collaboration with Bennett Novitch, Harley Kornblum, and Martina Wiedau-Pazos of the University of California Los Angeles, researchers compared the ability of different human cell lines to generate motor neuron progenitors and fully differentiated motor neurons. "These findings support the possibility that reprogrammed somatic cells might prove to be a viable alternative to embryo-derived cells in regenerative medicine," the authors note.

When measuring the electrophysical properties of the iPS-derived neurons, the researchers found that the iPS cells followed a normal developmental progression to mature, electrically active neurons.

"It seems possible that disease-specific somatic cells may be reprogrammed and utilized to model, and ultimately to treat a variety of human neurological disorders," says Miodrag Stojković, co-editor of the journal.


'/>"/>

Contact: Sean Wagner
journalnews@bos.blackwellpublishing.net
781-388-8550
Wiley-Blackwell
Source:Eurekalert

Related biology news :

1. UNH researchers studying spiny dogfish, Gulf of Maines mini shark
2. UT Southwestern researchers identify molecule that helps the sleep-deprived to mentally rebound
3. Case Western Reserve researchers develop wireless activation of brain circuits
4. Caltech and UCSD researchers shed light on how proteins find their shapes
5. Researchers call for nitrogen and phosphorus reductions to combat eutrophication in aquatic systems
6. Researchers explore new driver of transplant rejection: Platelets
7. Forget the antioxidants? McGill researchers cast doubt on role of free radicals in aging
8. Researchers isolate protein domain linked to tumor progression
9. CSHL researchers identify gene that helps plant cells keep communication channels open
10. Researchers identify gene linked to aggressive progression of liver cancer
11. Case Western Reserve researchers looking at light-induced toxins in air and water
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/6/2017)... 2017  SomaLogic announced today that it has ... by iCarbonX, the China -based ... Digital Health Ecosystem that can define each person,s ... biological, behavioral and psychological data, the Internet and ... SomaLogic will provide proteomics data and applications expertise ...
(Date:1/3/2017)... VEGAS , Jan. 3, 2017 Onitor, ... the introduction of Onitor Track, an innovative biometric data-driven ... men, showcasing this month at the 2017 Consumer Electronics ... In the U.S., the World Health ... more than two-thirds of adults who are overweight or ...
(Date:12/20/2016)... 2016   Valencell , the leading innovator ... STMicroelectronics (NYSE: STM), a global semiconductor leader serving ... today the launch of a new, highly accurate ... includes ST,s compact SensorTile turnkey multi-sensor ... sensor system. Together, SensorTile and Benchmark deliver the ...
Breaking Biology News(10 mins):
(Date:1/11/2017)... Angeles, California (PRWEB) , ... January 11, 2017 ... ... approach to support fertility specialists with accurate and reliable preimplantation genetic screening (PGS). ... we have achieved excellent results,” says Ovation Fertility Genetics Scientific Director Amy ...
(Date:1/11/2017)... 11, 2017  Brian Mehling, M.D., world-renowned stem cell ... Horizon International (BHI), will be attending the 47th Annual ... from January 17-20, 2017. This will be Dr. ... The theme of this year,s forum is Responsive and ... will address strategies for fostering greater social inclusion and ...
(Date:1/11/2017)... , ... January 11, 2017 , ... ... scientific grants to ground-breaking microbiome studies. Its most recent microbiome impact grant award ... who will study the effect of long-term use of oral antibiotics, prescribed for ...
(Date:1/11/2017)... ... January 11, 2017 , ... Symbios ... today that the National Science Foundation (NSF) has awarded Symbios a Small ... be used to commercialize the Symbios Tubular Plasma Reactor™ (TPR™) by scaling the ...
Breaking Biology Technology: