Navigation Links
Researchers gain new insights into how tumor cells are fed
Date:8/7/2011

Philadelphia, PA, August 8, 2011 Researchers have gained a new understanding of the way in which growing tumors are fed and how this growth can be slowed via angiogenesis inhibitors that eliminate the blood supply to tumors. This represents a step forward towards developing new anti-cancer drug therapies. The results of this study have been published today in the September issue of The American Journal of Pathology.

"The central role of capillary sprouting in tumor vascularization makes it an attractive target for anticancer therapy. Our observations suggest, however, that targeting just this mode of blood vessel formation may not be sufficient to result in a significant antitumor effect," commented lead investigators Sndor Paku, PhD, Semmelweis University, Budapest, and Balazs Dome, MD, PhD, Medical University of Vienna.

Investigators from the Semmelweis University, the National Institute of Oncology, and the National Koranyi Institute of Pulmonology, Budapest, Hungary, and the Medical University of Vienna, Vienna, Austria, used electron and confocal microscopy to examine tumor tissue in mice in which malignant tumor cells had been introduced. They proposed a novel mechanism for the development of tissue pillars (the most characteristic feature of intussusceptive angiogenesis, in which a vessel folds into itself to form two vessels). Moreover, they demonstrated a significant increase in pillar formation after treatment with the angiogenesis inhibitor vatalanib. Their observations support the notion that inhibition of just a single tumor vascularization mechanism can trigger alternative ones.

Prior to this study, the mechanism of pillar formation had not been fully understood. Investigation revealed a progression of events that generates a connection between the processes of endothelial bridging and intussusceptive angiogenesis resulting in rapid pillar formation from pre-existing building blocks. To describe this mechanism of
'/>"/>

Contact: David Sampson
ajpmedia@elsevier.com
215-239-3171
Elsevier Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. University of Virginia researchers uncover new catalysis site
2. U of Minnesota researchers discover a natural food preservative that kills food-borne bacteria
3. Researchers develop fully cooked food-aid product
4. U of M researchers use improved imaging technique; discover a better approach to diagnosing epilepsy
5. RUB researchers decipher the molecular basis of blue-green algae
6. Researchers discover the mechanism that determines cell position in the intestinal epithelium
7. Caltech researchers increase the potency of HIV-battling proteins
8. Researchers tap yeasts as source of green surfactants
9. Lawson researchers take control of cancer
10. U researchers look to dogs to better understand intricacies of bone cancer
11. Penn researchers help graft olfactory receptors onto nanotubes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/15/2014)... Conn. , Oct. 15, 2014 NXT-ID, Inc. (NASDAQ: ... biometric authentication company focused on the growing mobile commerce market releases ... MarketSite in Times Square on Monday October 13 th . ... CTO David Tunnel and angel investor Mr. Chad ... Pereira , CEO of NXT-ID thanked his investors and employees "for ...
(Date:10/14/2014)... Like discriminating thieves, prostate cancer tumors scavenge and hoard ... But such avarice may be a fatal weakness. ... to kill prostate cancer cells by delivering a trove ... the diseased cells brimming with the mineral, leaving non-cancer ... drugs already commercially available for other uses, could soon ...
(Date:10/14/2014)... Scientists have sequenced the house fly genome for the ... expect from an insect that thrives in pathogen-rich dung ... 14 in the journal Genome Biology , will ... of how flies quickly adapt to resist insecticides, which ... flies (Musca domestica) carry and transmit more than 100 ...
Breaking Biology News(10 mins):Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 2Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 3Prostate cancer's penchant for copper may be a fatal flaw 2House fly genome reveals expanded immune system 2
... -- Researchers at Polytechnique Montral have succeeded in changing ... transfection method. This major breakthrough in nanosurgery opens the ... treatment of cancers. , A light scalpel to ... Professor Michel Meunier and his team uses a femtosecond ...
... major challenges whether climate change, environmental pollution, urbanisation, ... sweeping shift in our approach to sustainability research ... European policy makers today during the launch of ... for our Unstable Earth" (RESCUE). A joint initiative ...
... series of 15 scientific papers published this week in ... Genetics and G3: Genes|Genomes|Genetics ) put ... called the Collaborative Cross a "library" of genetic ... about genetics and disease into new discoveries, tests, and ...
Cached Biology News:Europe needs a 'RESCUE' revolution 2Europe needs a 'RESCUE' revolution 3North Carolina-based genetic resources fuel big scientific progress 2North Carolina-based genetic resources fuel big scientific progress 3
(Date:10/22/2014)... and BOSTON , Oct. 22, ... a leading global specialty pharmaceutical company, and Rhythm, a ... an exclusive option to acquire Rhythm,s wholly owned subsidiary, ... peptide ghrelin agonist, for the treatment of diabetic gastroparesis ... has completed a successful Phase 2 trial of relamorelin ...
(Date:10/22/2014)... The North American crystal oscillator market report defines ... and forecast of revenue. This market was valued at ... $623.6 million by 2018, at a CAGR of 3.3% ... of the North American crystal oscillator market report, to ... also provides a glimpse of the segmentation of the ...
(Date:10/22/2014)... Massachusetts (PRWEB) October 22, 2014 ... announced the release of a new infographic, Understanding ... to create a beautifully designed, easy to follow informative ... transmission, areas of outbreak, symptoms and prevention. , "As ... discovered that the 2014 Ebola outbreak represents not only ...
(Date:10/22/2014)... 22, 2014 Currently offering a ... & D Weighing, Rice Lake, and Ohaus, Pipette.com ... . The Sartorius CPA Semi-Micro Balance is ideal ... precise, and user-friendly laboratory balance. , Sartorius is ... their laboratory balances are well known for their ...
Breaking Biology Technology:Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 2Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 3Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 4Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 5The North American crystal oscillator market is expected to reach $623.6 million by 2018 - New Report by MicroMarket Monitor 2The North American crystal oscillator market is expected to reach $623.6 million by 2018 - New Report by MicroMarket Monitor 3The North American crystal oscillator market is expected to reach $623.6 million by 2018 - New Report by MicroMarket Monitor 4Involution Studios' Ebola Infographic Provides Key Disease Information and Statistics at a Glance 2Pipette.com Launches the Addition of Sartorius CPA Semi-Micro Balance to Their Product Portfolio with Special Promotional Pricing 2Pipette.com Launches the Addition of Sartorius CPA Semi-Micro Balance to Their Product Portfolio with Special Promotional Pricing 3
... system receives Health Canada clearance to treat severe ... vascular dyschromia and wrinkles, MOUNTAIN VIEW, Calif., Aug. ... and market leader of aesthetic,laser skin treatments, today announced ... the recent Health Canada Clearance. The Canadian,debut of the ...
... Pork Back to Farm of Origin, NORTHFIELD, ... Brand, a leader in premium, all-natural fresh pork, ... DNA for reliable and accurate,traceability back to the ... use IdentiGEN,s DNA TraceBack(R) system, a USDA Process,Verified, ...
... ReceptorBio,Inc. announced today that it has entered into ... (Nasdaq: TELK ) that would enable ReceptorBio ... insulin,receptor activators. These compounds were identified through the,application ... provides for payments related to regulatory milestones and,royalties ...
Cached Biology Technology:Reliant Technologies Announces Canadian Launch of Fraxel re:pair(R) Laser: A New Class of Treatment Therapy for CO2 Laser Skin Resurfacing 2Reliant Technologies Announces Canadian Launch of Fraxel re:pair(R) Laser: A New Class of Treatment Therapy for CO2 Laser Skin Resurfacing 3Reliant Technologies Announces Canadian Launch of Fraxel re:pair(R) Laser: A New Class of Treatment Therapy for CO2 Laser Skin Resurfacing 4Nature's Premium(R) Brand First Fresh Pork in North America to Carry DNA TraceBack(R) Seal of Authenticity 2Nature's Premium(R) Brand First Fresh Pork in North America to Carry DNA TraceBack(R) Seal of Authenticity 3Nature's Premium(R) Brand First Fresh Pork in North America to Carry DNA TraceBack(R) Seal of Authenticity 4ReceptorBio Announces Diabetes License Agreement With Telik 2ReceptorBio Announces Diabetes License Agreement With Telik 3
Purified anti-LAT...
Nuclear/Cytosol Fractionation Kit Research Focus: other Storage Temperature: 4C Shipping Temperature: 4C...
Cytosol/Particulate Rapid Separation Kit Research Focus: other Storage Temperature: -20C Shipping Temperature: 4C...
Request Info...
Biology Products: