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Researchers gain insight into mechanism underlying Huntington's
Date:7/13/2009

with DNA replication and/or repair. These hairpin structures are highly thermo-stable and do not "melt" under normal physiologic conditions, and thus they are perceived as "fixed" in the DNA once formed, thereby leading to TNR expansions.

Using an extract of human cells, Li and his colleagues identified a novel DNA repair pathway referred to as DNA hairpin repair (HPR), which specifically targets TNR hairpin removal in the daughter DNA strand, ensuring the fidelity of the TNR sequences in the parental strand. It is proposed that defects or inadequacies in the HPR system may be responsible for TNR instability in the disease state.


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Contact: Keith Hautala
keith.hautala@uky.edu
859-323-6363
University of Kentucky
Source:Eurekalert

Page: 1 2

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