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Researchers find that one type of stem cell creates a niche for another type in bone marrow
Date:8/12/2010

ay to the bone marrow.

The collaborators found that genetic factors that are essential for HSC maintenance are highly concentrated within the neighboring MSCs. "The expression of these factors are least 500-fold higher in the MSCs than in other bone marrow cells, which shows why HSCs are so highly dependent on the MSCs," says Enikolopov.

"These results are a definitive indication that the MSCs are required for HSC maintenance as well as their homing to the bone marrow," says Tatyana Michurina, Ph.D., a research investigator in Enikolopov's laboratory who is an expert on both MSCs and HSCs. "After studying them as separate entities for years, it was such a surprise to discover that it was the MSCs that helped the HSCs to remain stem-like and primitive."

"These findings suggest that if we can control the niche, we can also manipulate the HSC population within," says Enikolopov. Pharmacological targeting of the niche might help enhance stem cell production for use in regeneration therapies or might help stave off adverse events like leukemia or other disorders where stem cells proliferate out of control.


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Contact: Hema Bashyam
bashyam@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3

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