Navigation Links
Researchers find that one type of stem cell creates a niche for another type in bone marrow
Date:8/12/2010

up with a multi-institutional group led by Paul Frenette, M.D., of Mount Sinai School of Medicine, and which also included scientists from Harvard Medical School and the Albert Einstein College of Medicine.

Examining bone marrow sections from the nestin-expressing mice and based on the presence of various molecules on the populations of cells found within, the team identified the nestin-expressing cells as MSCs. These cells, which outnumber the HSCs 10:1, were either in direct contact with the HSCs or in clusters around them.

"This close proximity suggested that there might be some kind of molecular signaling or cross-talk going on that might control HSC maintenance," explains Enikolopov, who has been investigating the consequence of this kind of cell-cell dialogue during tissue and organ development. "One hypothesis is that this interaction directs and regulates growth by teaching different types of cells where they ought to locate themselves and what they should do there."

This seems to be the case, at least in the bone marrow, as the collaborators found that altering the numbers of MSCs has a corresponding effect on the numbers of HSCs. Increasing the numbers of MSCs by injecting mice with a growth hormone caused HSCs to double in number. Inhibiting MSC proliferation via infusions of growth-inhibiting proteins, on the other hand, was followed by a dip in HSC numbers.

The collaborators also explored the consequence of completely eradicating bone marrow MSCs using genetic tools developed in Enikolopov's lab. The CSHL scientists created mice in which only nestin-expressing cellsthe MSCswere programmed to carry a receptor for a toxin molecule. Injecting mice with the toxin thus selectively wiped out the MSCs. As a result, the scientists observed a four-fold reduction in the numbers of HSCs in the bone marrow of these mice. In the absence of bone marrow MSCs, large numbers of HSCs injected into the mice also failed to make their w
'/>"/>

Contact: Hema Bashyam
bashyam@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. NC State researchers get to root of parasite genome
2. Researchers find animal with ability to survive climate change
3. Researchers find an essential gene for forming ears of corn
4. Researchers note differences between people and animals on calorie restriction
5. Researchers study acoustic communication in deep-sea fish
6. Researchers discover that growing up too fast may mean dying young in honey bees
7. Researchers study how pistachios may improve heart health
8. UI researchers find potentially toxic substance present in Chicago air
9. Researchers develop new self-training gene prediction program for fungi
10. Case Western Reserve University researchers track Chernobyl fallout
11. Childrens National researchers develop novel anti-tumor vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/16/2015)... , June 16, 2015 Fingerprint Cards ... communicated that it will amount to at least 340 MSEK ... to the rapid increase in market growth and orders received ... communicated guidance that revenue for 2015 will exceed 1,500 MSEK ... to approximately 2,200 MSEK. Due to receipt of ...
(Date:6/15/2015)... 15, 2015 A new report [ ... the majority of US consumers using mobile banking applications want ... as fingerprint and voiceprint, instead of having to prove who ... Telstra,s " Mobile Identity   -   The Fusion of ... smartphones now the primary channel used by Gen X and ...
(Date:6/12/2015)... June 12, 2015  Securus Technologies, a leading ... for public safety, investigation, corrections and monitoring, announced ... to electronically capture, analyze and identify participants of ... methods. This system can: ... enrollment and subsequent sign-on process is actually the ...
Breaking Biology News(10 mins):Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 2Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 3One in Four US Consumers Would Share Their DNA With Their Bank to Secure Financial and Personal Information, Telstra Report Finds 2One in Four US Consumers Would Share Their DNA With Their Bank to Secure Financial and Personal Information, Telstra Report Finds 3One in Four US Consumers Would Share Their DNA With Their Bank to Secure Financial and Personal Information, Telstra Report Finds 4Securus Announces Patent Issued for Authorized Presence Verification During Video Visitation 2
... skin. Cancer is not a static disease but during ... defences adapting to new environmental circumstances, protecting against chemotherapy ... Until now little was known about the mechanisms ... is a particularly intriguing way in which a tumour ...
... of carbon in the world,s oceans, which cover 70 ... climate cycles, with many questions remaining unanswered. Between 200 ... "twilight zone" where insufficient sunlight penetrates for microorganisms to ... resident at these depths capture carbon dioxide that they ...
... of spring-run Chinook salmon in California by the end ... at UC Davis, the Stockholm Environment Institute and the ... for managing water resources to protect the salmon runs, ... Thompson, director of the Center for Aquatic Biology and ...
Cached Biology News:Why cancer cells change their appearance? 2Up from the depths: How bacteria capture carbon in the 'twilight zone' 2Warming streams could be the end for salmon 2
(Date:7/1/2015)... 1, 2015   Decision Resources Group ... of Otezla are its oral administration, alternative mechanism ... by surveyed rheumatologists. Otezla was the first oral ... of active psoriatic arthritis in the ... care includes conventional oral treatments including disease-modifying antirheumatic ...
(Date:7/1/2015)... Calif. , July 1, 2015   ... on the development of groundbreaking drugs to treat ... announced today that Robert G. Miller , ... at Sutter Health,s California Pacific Medical Center in San ... ALS Association for $1.5 million to help fund ...
(Date:7/1/2015)... ... July 01, 2015 , ... A newly launched business plan ... lower the barriers to innovation in life sciences R&D. The Pistoia Alliance President’s Startup ... prizes of US$15,000 and a period of expert mentorship from a senior industry figure ...
(Date:7/1/2015)... ... 01, 2015 , ... NEMA 4 (IP66) Medical Joysticks can ... Joysticks have an impermeable molecular barrier protection against bio-hazardous agents. Original Equipment ... increase healthcare worker safety and reduce financial costs. , CTI Electronics announces a ...
Breaking Biology Technology:Surveyed Rheumatologists Report That Otezla's Oral Administration is its Single Greatest Advantage Over Currently Available Treatment Options 2Surveyed Rheumatologists Report That Otezla's Oral Administration is its Single Greatest Advantage Over Currently Available Treatment Options 3Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 2Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 3Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 4Pistoia Alliance Launches Startup Challenge 2Pistoia Alliance Launches Startup Challenge 3Sanitized Medical Joysticks for a Safer and Healthier Work Environment 2
... April 30 Today John C. Lechleiter,Ph.D., president ... LLY ), provided,insight into the future of ... players, significant investments in the sector are rewarded. ... a gathering of,policymakers, business leaders and academics, under ...
... 30 Intense global competition,and today,s networked economy ... Alliances as the strategy of the next century. ... it to be sustainable and,mutually beneficial., How ... study on Forging,Partnerships That Work is a roadmap ...
... Inc. (Nasdaq: PBIO ) today announced that the ... 2008 financial results and to,provide a business update. Anyone ... through a live web-cast. The,teleconference and web-cast information is ... Time: 9:00 a.m. Eastern Time (ET), To attend ...
Cached Biology Technology:Lilly CEO Urges Policy Prescriptions to Help Ensure Public and Private Biotech Investments Generate Dividends and U.S. Job Growth 2Lilly CEO Urges Policy Prescriptions to Help Ensure Public and Private Biotech Investments Generate Dividends and U.S. Job Growth 3Biopharmaceutical Alliances: Forging Partnerships That Work 2Pressure BioSciences, Inc. to Discuss First Quarter 2008 Financial Results and Provide Business Update 2
IMAGEQUANT 100 IQTL, 1 EA. Category: ImageQuant CCD Imagers....
ImageQuant 100 UV, 1 EA. Category: ImageQuant CCD Imagers....
The FlowTACS Apoptosis Detection Kit is designed specifically for in situdetection of apoptotic...
...
Biology Products: