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Researchers find snippet of RNA that helps make individuals remarkably alike
Date:5/5/2009

when the researchers eliminated miR-7, the networks remained intact but only under uniform environmental conditions. When the researchers perturbed the environment by modulating the temperature, the networks failed to keep things intact, and animals suffered from developmental defects. If the microRNA was present, however, the networks resisted the temperature fluctuation, and animals were normal and healthy.

MicroRNAs, found in all plants and animals, may have evolved as tiny buffers within multicellular organisms to allow the remarkable unity of form in a constantly changing environment.

"This idea has health implications as well," said Carthew. "Cancer cells are notoriously heterogeneous and do not act in controllable ways. Interestingly, microRNAs are among the most frequently mutated targets in cancers, leading some to speculate that their absence is linked to cancer's heterogeneous behavior."


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Contact: Megan Fellman
fellman@northwestern.edu
847-491-3115
Northwestern University
Source:Eurekalert

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