Navigation Links
Researchers find snippet of RNA that helps make individuals remarkably alike
Date:5/5/2009

"No two people are alike." Yet when we consider the thousands of genes with frequent differences in genetic composition among different people, it is remarkable how much alike we are.

Uniformity, or singleness of form, is not unique to humans but a general property of life. Biologists have long pondered how this feature is produced in the face of such great variation in genetics as well as environmental conditions.

Northwestern University researchers now have identified a type of molecule that plays a specific role in maintaining uniformity: a little snippet of RNA called a microRNA. They found that a microRNA called miR-7 is critical to the robustness of the molecular network that helps regulate uniformity.

The findings are published online by the journal Cell and also are featured in a Cell podcast: http://www.cell.com/. This knowledge could lead to a better understanding of the workings of cancer cells, which do not act in controllable, uniform ways.

The Northwestern research builds on an idea that originated in the 1940's: Molecules within cells of the body work together in networks, each molecule interconnected with others.

"When something is changed, say the genetic sequence of a molecule or the temperature of the organism, the network responds to compensate for the change and keep things intact," said Richard W. Carthew, Owen L. Coon Professor of Molecular Biology in the Weinberg College of Arts and Sciences at Northwestern. Carthew led the research. "This design is similar to the principle that engineers use to design safety features into products."

There are hundreds of different types of microRNAs in animals. Their function is to dampen or shut down the production of proteins in the body. The Carthew group found one of these microRNAs, miR-7, dampens production of proteins that work in the same networks as miR-7.

In a study of Drosophila,
'/>"/>

Contact: Megan Fellman
fellman@northwestern.edu
847-491-3115
Northwestern University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Stowers researchers develop whole genome sequencing approach for mutation discovery
2. Pfizer supports open access publishing for researchers in low-income countries
3. Genetic secrets of date palm unlocked by researchers at Weill Cornell Medical College in Qatar
4. Researchers identify a molecule that increases the risk of cardiac insufficiency
5. Researchers discover that gene switches on during development of epilepsy
6. Researchers report moderately large potential for red tide outbreak in Gulf of Maine region
7. UT Southwestern researchers probe kidney damage, protection in lupus
8. Researchers use brain interface to post to Twitter
9. TGen researchers discover possible way to block the spread of deadly brain tumors
10. Burnham researchers present at 100th AACR Meeting
11. Yale researchers uncover secrets of salmonellas stealth attack
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... wildfires that have been plaguing the Northern Territories in ... Great Lakes in the U.S. continue on. NASA,s ... Resolution Imaging Spectroradiometer, MODIS, instrument on July 26, 2014. ... outlined in red. Copious amount of smoke are drifting ... havoc for residents of Yellowknife. Fire has caused ...
(Date:7/29/2014)... University of Maryland Schools of Dentistry (UM SOD) ... they have received a five-year $10.7 million grant ... Infectious Diseases (NIAID) of the National Institutes of ... of sexually-transmitted diseases (STDs). The grant, which renews ... represents a new direction for the research by ...
(Date:7/29/2014)... to go and almost 2500 registered participants, the final ... The event, a joint venture between the Federation of ... for Biochemistry and Molecular Biology (SFBBM), will take place ... the Palais des Congrs in Paris, France. , The ... life sciences in Europe this year. It features more ...
Breaking Biology News(10 mins):University of Maryland Schools of Dentistry and Medicine receive NIH grant 2University of Maryland Schools of Dentistry and Medicine receive NIH grant 3University of Maryland Schools of Dentistry and Medicine receive NIH grant 4Counting down to FEBS-EMBO 2014 in Paris, France 2
... as it has become known, began on March 11, ... recorded. Following the quake, a 40 to 50-foot tsunami ... estimated 20,000 missing or dead. The massive wave also ... plant. , The release of radioactivity from Fukushimaboth as ...
... may be the 21st century, but nearly half the ... or primitive stoves that burn wood, animal dung, charcoal ... ACS journal Environmental Science & Technology describes ... the obstacles that remain. Susan C. Anenberg ...
... its detection when mixed into meatballs and other food and ... is food for a thoughtful installment of the popular Newscripts ... News . C&EN is the weekly newsmagazine of the American ... Tullo, C&EN senior editor, uses the story to look behind ...
Cached Biology News:Meeting: 'Experts Convene to Examine Impacts of Fukushima on the Ocean' 2
(Date:7/29/2014)... a number of significant technological challenges in their ... originally created for the James Webb Space Telescope. ... Moseley, a scientist at NASA,s Goddard Space Flight ... actuated microshutter arrays that is, those activated ... functional as the current technology,s magnetically activated arrays. ...
(Date:7/29/2014)... HOUSTON (July 29, 2014) Tough, ultralight foam ... and shape through a chemical process invented at Rice ... "GO-0.5BN" looks like a nanoscale building, with floors and ... a pair of two-dimensional materials: floors and walls of ... boron nitride platelets. , The researchers say the ...
(Date:7/29/2014)... 29, 2014 According to the ... Imaging), Analytics (Image Analysis Software), Delivery Modes (Web Based/Cloud ... & Trends to 2018", published by MarketsandMarkets, analyzes and ... such as North America , ... and the Rest of the World (RoW). ...
(Date:7/29/2014)... HILLS, Calif. , July 29, 2014 /PRNewswire/ ... specializing in personalized medicine, treatment of infectious diseases ... strategies of prognosis and prevention of pathologies like ... of August 1, 2014, ImmunoClin Corporation will complete ... Washington, D.C. , a key ...
Breaking Biology Technology:Revolutionary microshutter technology hurdles significant challenges 2Revolutionary microshutter technology hurdles significant challenges 3Revolutionary microshutter technology hurdles significant challenges 4Tough foam from tiny sheets 2Digital Pathology Market worth $437 Million by 2018 2Digital Pathology Market worth $437 Million by 2018 3ImmunoClin Corporation (IMCL) Relocates Corporate Headquarters to Washington, DC 2ImmunoClin Corporation (IMCL) Relocates Corporate Headquarters to Washington, DC 3
... will discuss the fourth quarter and year end,financial results for the fiscal year ended June ... 30, 2008 at 11:15 a.m. ET., Conference Call and Webcast Access Information, ... Call - Live ... 11:15 a.m. ET Domestic Dial-In Number ...
... introduced for the first time in the U.S. at the 16th annual ... on Oct. 2-4. , ... HOUSTON (Business Wire EON) September 30, ... assist device (VAD) that benefited from years of hands-on leadership and support ...
... 30 Verenium,Corporation (Nasdaq: VRNM ), a ... high-performance specialty enzymes, announced today,that Janet Roemer, Executive ... present at the upcoming William Blair & Company ... to begin,at 10:40 a.m. ET on Tuesday, October ...
Cached Biology Technology:Palatin Technologies, Inc. Revised Call-In Number for Teleconference and Webcast to be held on September 30, 2008 2 The Modern DeBakey VAD™ To Be Introduced For the First Time in the U.S. : HeartAssist 5™ Pediatric VAD Features Industry Exclusive Direct Blood Flow Measurement System 2 The Modern DeBakey VAD™ To Be Introduced For the First Time in the U.S. : HeartAssist 5™ Pediatric VAD Features Industry Exclusive Direct Blood Flow Measurement System 3Verenium Corporation to Present at the William Blair & Company 2008 Small-Cap Growth Stock Conference 2Verenium Corporation to Present at the William Blair & Company 2008 Small-Cap Growth Stock Conference 3
Direct ELISA Assay Diluent - EDTA, 10 L...
... Turn routine agarose gel electrophoresis into ... 96 system. This bufferless, pre-cast system is ... preparations, restriction digests, and more. Fully automated, ... the E-Gel 96 system makes your high-throughput ...
SpectroQuest single beam 4nm UV/Vis spectrophotometer; stand-alone unit; large angled LCD screen; large sample compartment...
... Cloning Kit, 40 reactions. Optimized for ... all PCR products with blunt or ... by offering consistently better signal-to-noise ratios ... positive clones.Amplicons generated by proof-reading thermostable ...
Biology Products: