Navigation Links
Researchers find safer way to use common but potentially dangerous medication
Date:2/29/2012

rope, and Asia, tracked 1,342 patients on days six through 11 after beginning treatment with warfarin. The team considered factors such as individual body mass index, medication usage, age, gender, and whether or not the patients carried two genes that are known to influence the way warfarin affects the body.

From those data, Dr. Horne and his colleagues were able to create a mathematical model to predict individual patient response to warfarin. The group applied their new algorithm to 342 different patients to validate that it could accurately predict patient response to the drug and help determine more appropriate dosages.

"We discovered that the algorithm is significantly more precise and accurate in identifying the best dose for an individual patient," said Dr. Horne.

He said the body's response to warfarin stabilizes after the second week of treatment, and that the algorithm can determine the safest dose possible for the full course of warfarin treatment. Researchers believe future studies will demonstrate the financial, as well as clinical, benefits of conducting genetic tests needed to perfect the dosing for individual patients.

"This is a very hopeful first step in that direction," said Dr. Horne. "I expect we'll see more studies in the future that show the real effect this tool will have on the lives of patients."

The algorithm is the latest research on genetics and warfarin dosing at Intermountain Medical Center. An earlier project, led by Intermountain Heart Institute cardiologist Jeffrey L. Anderson, MD, examined the effectiveness of genetic testing on warfarin use.

Both group's findings are being used to build a computer tool that works within Intermountain Healthcare's electronic medical record system and that will perform warfarin calculations automatically, thereby increasing patient safety.

"This promises to be a powerful tool to tailor warfarin dosing to each individual patient," sai
'/>"/>

Contact: Jess C. Gomez
jess.gomez@imail.org
801-507-7455
Intermountain Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. SFU researchers help discover new HIV vaccine-related tool
2. Notre Dame researchers are providing insights into elephant behavior and conservation issues
3. Researchers develop worlds first biodegradable joint implant
4. Researchers identify novel pathway responsible for infection of a common STD pathogen
5. Researchers discover how vitamin D inhibits inflammation
6. Purdue researchers reveal role of protein mutation in Parkinsons disease
7. UVic researchers among presenters at global science conference
8. Researchers develop better control for DNA-based computations
9. Researchers warn nanoparticles in food, vitamins could harm human health
10. Worlds top technology researchers coming to Queens for TEI 2012
11. Researchers make living model of brain tumor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/16/2014)... body. Battles are won, lost or sometimes end ... as tumor dormancy—can last up to 25 years ... poorly understood. , A new computational model ... Professor of Chemistry at Princeton University, may help ... switch to a malignant state. Published today in ...
(Date:10/16/2014)... cultivated efficiently, they are anything but sustainable: environmental ... cultivation is becoming increasingly evident. Despite their disadvantages, ... are regarded as the sole possibility of achieving ... finds Bernhard Schmid, an ecology professor at the ... of agriculture and forestry. After all, a new ...
(Date:10/15/2014)... 15, 2014 Sandata Technologies, LLC, an ... community-based care, today announced it released a case ... Electronic Visit Verification™ Solution (EVV™)  for Quality Care ... health company founded in 1996 and has five ... The study details the challenges facing ...
Breaking Biology News(10 mins):Modeling tumor dormancy 2Plant communities produce greater yield than monocultures 2Plant communities produce greater yield than monocultures 3Sandata Announces Case Study with Quality Care Services, Inc. 2
... from brake linings and mining operations can affect salmon ... a Washington State University researcher. Jenifer McIntyre found the ... they won,t detect a compound that ordinarily alerts them ... is not getting the information it needs to make ...
... Switzerland. Research to be presented at the Annual Meeting of ... foremost society for research into all aspects of eating and ... reduces the quality of sleep in rats. Using radio-telemetry, ... consumed a high fat diet for 8 weeks. Compared to ...
... debilitating illnesses one can develop. Currently, the disease afflicts 6.5 ... to between 11 and 16 million, or 1 in 85 ... one to grow forgetful, confused and, eventually, catatonic. Recently approved ... consensus on the underlying mechanism of the disease. "We ...
Cached Biology News:Copper making salmon prone to predators 2Small molecule may play big role in Alzheimer's disease 2Small molecule may play big role in Alzheimer's disease 3Small molecule may play big role in Alzheimer's disease 4
(Date:10/22/2014)... NEW YORK , Oct. 22, 2014 ... growth in the in vitro diagnostic (IVD) test industry, ... Kalorama Information. The healthcare market researcher listed more than 25 ... that could be the future of IVD products. Kalorama details ... industry, The Worldwide Market for In Vitro Diagnostic ...
(Date:10/22/2014)... 22, 2014 Research and Markets ... "Global DNA Diagnostics Market (Product types, Application, Technology, ... Trends, Company Profiles, Demand, Insights, Analysis, Research, Report, ... report to their offering. This ... techniques, end users and Geography) Global Size, Industry ...
(Date:10/22/2014)... BOSTON , Oct. 22, 2014  Actavis ... specialty pharmaceutical company, and Rhythm, a biopharmaceutical company, today ... to acquire Rhythm,s wholly owned subsidiary, Rhythm Health, Inc., ... for the treatment of diabetic gastroparesis and other GI ... successful Phase 2 trial of relamorelin for the treatment ...
(Date:10/22/2014)... The Americas Inorganic Refrigerants Market report defines ... with analysis and forecast of revenue. , Browse ... Market report, to get an idea of the ... of the segmentation in the Americas inorganic refrigerants ... figures. , http://www.micromarketmonitor.com/market/americas-inorganic-refrigerants-4191654241.html , Inorganic ...
Breaking Biology Technology:Report: Radical New IVD Test Approaches Key To Growth 2Report: Radical New IVD Test Approaches Key To Growth 3Global DNA Diagnostics Market (Product types, Application, Technology, End User and Geography) - Forecast to 2020 2Global DNA Diagnostics Market (Product types, Application, Technology, End User and Geography) - Forecast to 2020 3Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 2Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 3Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 4Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 5The Americas Inorganic Refrigerants Market is estimated to grow to $71.6 million by 2018 - New Report by MicroMarket Monitor 2The Americas Inorganic Refrigerants Market is estimated to grow to $71.6 million by 2018 - New Report by MicroMarket Monitor 3
... The Silencer siRNA , ... column purification to prepare transfection-ready siRNAs. With , ... is one example of how siRNAs prepared by the , ... in gene silencing studies. , ...
... (LCM) is a method for obtaining pure populations of cells ... permits the selection and capture of , ... thin tissue sections. For LCM, frozen and OCT embedded, or ... tissue sections are processed, , ...
... by Sapna Chacko , ... High quality, DEPC treated, and non-DEPC , treated water , ... , Available in sizes to suit all your , ... for RNA isolation and analysis can contribute to experimental ...
Cached Biology Technology:Your Data: Silencing Hepatitis C Virus Replication With In Vitro Transcribed siRNAs 2Working With Laser Capture Microdissection Samples 2Working With Laser Capture Microdissection Samples 3Which Water to Use? 2Which Water to Use? 3Which Water to Use? 4Which Water to Use? 5Which Water to Use? 6
Blasticidin resistance gene (bsr), provided in a pORF plasmid. pORF is an expression plasmid selectable with Ampicillin....
... These 2800mL PYREX Fernbach-style culture flasks have ... the flask bottom to achieve maximal oxygen ... a large marking spot., A wide range ... bottles including:, Polypropylene colored caps for ...
...
... mouth PYREX Fernbach-style culture flasks have triple ... flask bottom to achieve maximal oxygen transfer ... have a Delong-style 38mm neck for use ... plastic closures see Nos. CLS2679638 or CLS2679738. ...
Biology Products: