Navigation Links
Researchers find process of cervical ripening differs between term and preterm birth
Date:6/20/2011

entified risk factors for preterm birth include smoking, alcohol consumption, advanced maternal age, genetics, cervical insufficiency, previous preterm birth and infection.

"In about half of all preterm births, the cause is unknown. It's critical to determine the multiple causes of preterm birth so that effective therapies can be developed for each kind," said Dr. Roxane Holt, a maternal-fetal medicine fellow and co-lead author of the study.

"When patients present in preterm labor, we don't have a lot of therapy to stop the labor," she said.

UT Southwestern researchers compared preterm birth models in mice. They injected lipopolysaccharide (LPS) to promote infection-like conditions and an inflammatory response in one model. In the other, they administered mifepristone (RU486) to simulate the withdrawal of the gestation-supporting hormone progesterone, which normally takes place at the end of a pregnancy.

Researchers report that cervical changes in inflammation-induced conditions are caused by an influx of white blood cells and an increased expression of pro-inflammatory markers with no increase in the expression of genes induced in term ripening. Preterm ripening induced by progesterone withdrawal results from the combined activation of processes that occur during term ripening and shortly postpartum.

"These findings, if translatable in women, suggest one therapy may not be effective for all preterm births, and that early identification of the cause of prematurity is necessary to determine the correct therapy," Dr. Mahendroo said.


'/>"/>

Contact: Robin Russell
robin.russell@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Rensselaer researchers secure $2.7 million NIH grant to advance scarless surgery
2. USC researchers find new clues about protein linked to Parkinsons disease
3. GW researchers receive award from NCI to study cancer from a neglected tropical disease
4. MSU plant scientist named one of the nations most innovative researchers
5. Leaky genes put evolution on the fast track, Pitt and UW-Madison researchers find
6. Researchers predict record Gulf of Mexico dead zone due to Mississippi River flooding
7. Researchers identify why dopamine replacement therapy has a paradoxical effect on cognition
8. Researchers improve method for finding genetic mistakes that fuel cancer
9. Johns Hopkins researchers link cell division and oxygen levels
10. U-M researchers find potential new way to fight sepsis
11. Penn researchers show new evidence of genetic arms race against malaria
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... Mont. In the same week that the U.S. ... of skin cancer, researchers at Montana State University published ... the genetic code in every cell responds when ... fundamental understanding of DNA damage by the UV rays ... cancer, aging and some degenerative eye diseases. , ...
(Date:7/31/2014)... fat cells, are inherently different. Each of these cell ... role in metabolism. In the human body, white adipose ... function is energy storage. On the other hand, brown ... only found in a few places in the adult ... of brown adipocytes, appear mixed with brown adipocytes in ...
(Date:7/30/2014)... paving the way for a breakthrough that may ... exposed to poisonous chemicalsparticularly those in pesticides and ... current issue of the journal ChemBioChem ... compounds commonly used in pesticides and warfare agents. ... of Engineering Associate Professor of Chemical and Biological ...
Breaking Biology News(10 mins):New paper describes how DNA avoids damage from UV light 2New paper describes how DNA avoids damage from UV light 3Hope for the overweight 2Engineering a protein to prevent brain damage from toxic agents 2
... tools of chemistry and astronomy will use the unique ... basic chemistry from the restrictive bonds of Earth. ... scientists to explore new types of chemical reactions that ... center will combine laboratory experiments, theoretical studies, and radio-telescope ...
... pulses inside us all, guiding our daily cycle from ... be doing much more than just that simple metronomic ... hamsters, biologist Norman Ruby has shown that having a ... to remember what they have learned. Without it, he ...
... Jerusalem has found a way to genetically enhance the scent of ... Smell plays an important role in our lives: It influences ... even a partner. And yet, smell is not just what we ... Alexander Vainstein, who is heading the team at the Robert H. ...
Cached Biology News:Research center to free chemistry from Earth's bonds 2Circadian clock may be critical for remembering what you learn, Stanford researchers say 2Circadian clock may be critical for remembering what you learn, Stanford researchers say 3Circadian clock may be critical for remembering what you learn, Stanford researchers say 4Scent on demand: Hebrew University scientists enhance the scent of flowers 2
(Date:7/30/2014)... Calif. , July 30, 2014 ... a biopharmaceutical company leading the discovery and development of ... report financial results and highlights for the quarter ended ... the U.S. financial markets close. Regulus ... August 6, 2014, at 5:00 pm Eastern Daylight Time ...
(Date:7/30/2014)... W. R. Grace & Co. (NYSE: ... REVELERIS® Prep purification system , a dual-mode instrument ... researchers to perform both flash and preparative liquid ... the REVELERIS® Prep purification system, researchers can easily ... a simple touch of the screen, giving them ...
(Date:7/30/2014)... , July 30, 2014 A study ... the safety and efficacy of CSL Behring,s C1 ... kidney transplants in highly sensitized patients. C1-INH is ... the complement system. The study shows ... increases in the levels of complement components 3 ...
(Date:7/30/2014)... 30, 2014  Replikins Ltd. today released new data ... virus. Before the current outbreaks, the mean Ebola Reston ... acids) between 1995 and 2002 was 1.1; the mean ... and sixteen-fold in 2013, thus predicting the current outbreaks ... has been shown to be able to predict outbreaks ...
Breaking Biology Technology:Regulus Announces Timing for Second Quarter 2014 Financial Results Webcast and Conference Call 2Regulus Announces Timing for Second Quarter 2014 Financial Results Webcast and Conference Call 3Grace Launches New REVELERIS® Prep Purification System 2Study Suggests C1-INH May Aid in Prevention of Antibody-Mediated Rejection Following Kidney Transplant 2Study Suggests C1-INH May Aid in Prevention of Antibody-Mediated Rejection Following Kidney Transplant 3
... Carbon nanotubes have been employed for a variety of ... , While they have proven useful for these purposes, ... at the molecular level. For example, how do nanotubes ... the atomic scale" Answering this question could lead to ...
... NxStage Medical,Inc. (Nasdaq: NXTM ), a leading ... financial results for the third,quarter 2007 on Friday, November ... NxStage will also host a conference call at 10:00 ... third quarter 2007 financial results. To,listen to the conference ...
... Oct. 16 MacroChem,(OTC Bulletin Board: MACM) will ... at the Hilton New York on October 18 ... located outside the Sutton Room, throughout each day ... Robert,J. DeLuccia, will provide a company overview, including ...
Cached Biology Technology:Researchers measure carbon nanotube interaction 2NxStage(R) Medical to Report Third Quarter 2007 Financial Results on Friday, November 2nd 2MacroChem To Participate in PIPEs Conference October 18th and 19th in New York City 2MacroChem To Participate in PIPEs Conference October 18th and 19th in New York City 3
... purification systems provide high speed purification of ... offer increased throughput and reproducible results. The ... mL and KingFisher 96, covering sample volumes ... consists of an instrument, specially designed plastics ...
... Savant SpeedVac Concentrators set the standard for centrifugal ... uses a combination of centrifugal force, heat and ... run., SC110A comes equipped with:, , TEFLON-coated ... , Three ...
... to have active, real-time sample temperature monitoring. ... the worlds first, fully modular SpeedVac System. ... together to form an integrated unit or ... also the first SpeedVac to have sample ...
... The Jouan RC Standard Bio for ... applications of molecular biology and biochemistry for ... The RC systems can be expanded with ... wide selection of rotors (eliminating sample loss ...
Biology Products: