Navigation Links
Researchers find potential target for drug to treat allergic asthma
Date:3/5/2014

COLUMBUS, Ohio An enzyme that helps maintain immune system function by "throwing away" a specific protein has a vital role in controlling symptoms of allergic asthma, new research in mice suggests.

The finding suggests that this enzyme, called Cbl-b, could be a target for drugs used to treat allergic asthma and other autoimmune disorders.

This new study, led by Ohio State University researchers, is the first to link Cbl-b to allergic asthma in an animal model.

The findings parallel results from a 2012 Yale study in humans, which suggested that a mutation in the gene that produces Cbl-b was associated with higher risk for asthma in children. Other studies have suggested that inhibiting Cbl-b activity could reduce tumors and lower chances for cancer to spread.

Based on this assortment of findings, scientists believe Cbl-b could be manipulated in different ways depending on the disorder in question. Its activity could be elevated to keep excessive inflammation in check in people with allergic asthma, or it could be inhibited to treat cancer.

"We believe we have found one of the key molecules that can modulate the immune response," said Jian Zhang, associate professor of microbial infection and immunity at Ohio State and senior author of the study. "We can use this basic knowledge to try to find small molecules that can modify Cbl-b's function and use this to treat human diseases that include autoimmunity, asthma and tumors."

Allergic asthma is the most common form of asthma and is triggered by inhaling such allergens as dust mites, pet dander, pollen or mold, leading to inflamed and swollen airways of the lungs, according to the American Academy of Allergy Asthma & Immunology.

The Ohio State study is published in the current issue of the journal Cell Reports.

In this work, mice that are models for allergic asthma were injected with a substance that provoked an allergic response.
'/>"/>

Contact: Jian Zhang
Jian.Zhang@osumc.edu
614-292-9447
Ohio State University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Dartmouth researchers find promising results with local hyperthermia of tumors
2. Researchers develop antibody-targeted treatment for recurrent small-cell lung cancer
3. Researchers reveal the dual role of brain glycogen
4. Montreal researchers find a link between pollutants and certain complications of obesity
5. CNIO researchers discover new strategies for the treatment of psoriasis
6. Researchers trap moths with plant-produced sex pheromone
7. Researchers generate new neurons in brains, spinal cords of living adult mammals
8. Researchers at LSTM crack the genetic secret of mosquito resistance to DDT and ITNs
9. McMaster researchers discover secret of bowel movement
10. Researchers have identified a novel immunological mechanism of great importance for vaccine developm
11. Researchers pinpoint brain region essential for social memory
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... NXT-ID, Inc. (NASDAQ: NXTD and NXTDW) a biometric ... recent success of the Wocket™ smart wallet at CES 2015 in ... named as one of the "11 Hot Products at CES" in a ... CES So Far" by Newseveryday.com and "The top 10 gadgets from CES ...
(Date:1/22/2015)... , Jan. 21, 2015  Analyst Report Issued by Small Cap ... report showed that planet-wide, transactions at merchants on the leading ... total number of credit, debit, and prepaid cards reached 6.54 ... victims of fraudulent card usage in 2012, and credit and ...
(Date:1/22/2015)... and Markets ( http://www.researchandmarkets.com/research/wxdglm/global_wearable ) has ... Technologies Market and Applications, Opportunities, Industry Analysis, Segmentation, ... report to their offering. , ... be worn on the user,s body and have ...
Breaking Biology News(10 mins):CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3$4.80 Near Term Price Target with "Buy" given by CapRock Research for NXT-ID, Inc. (NASDAQ: NXTD) issued by Small Cap IR 2Global Wearable Technologies Market and Applications, Opportunities, Industry Analysis, Segmentation, Size, Growth, Share, Overview, Trends and Forecast 2014-2020 2
... National Institutes of Health is making available approximately ... for graduate students and postdoctoral scholars to prepare ... that could take them outside of conventional academic ... Broadening Experience in Scientific Training (BEST) awards are ...
... Geosphere has posted additions to several themed issues: ... Geodynamics and Consequences of Lithospheric Removal in the Sierra ... Snake River Plain-Yellowstone Region and Adjacent Areas; Origin and ... other articles cover terrestrial laser scanning and the earthquake ...
... University scientist Bryan Venters, Ph.D., has shed new light ... begun to explore a possible new approach to treating ... of Molecular Physiology and Biophysics who further developed the ... of Frank Pugh, Ph.D., at Pennsylvania State University before ...
Cached Biology News:NIH announces awards to strengthen the biomedical research workforce 2NIH announces awards to strengthen the biomedical research workforce 3Geosphere, GSA's dynamic online-only journal posts 9 new articles in Sept. 2Geosphere, GSA's dynamic online-only journal posts 9 new articles in Sept. 3Geosphere, GSA's dynamic online-only journal posts 9 new articles in Sept. 4Geosphere, GSA's dynamic online-only journal posts 9 new articles in Sept. 5Geosphere, GSA's dynamic online-only journal posts 9 new articles in Sept. 6Geosphere, GSA's dynamic online-only journal posts 9 new articles in Sept. 7Geosphere, GSA's dynamic online-only journal posts 9 new articles in Sept. 8Geosphere, GSA's dynamic online-only journal posts 9 new articles in Sept. 9Study helps bring genome's 'dark matter' into light 2
(Date:1/22/2015)... Controlled Substance Compliance Services (CSCS), a project ... the legal requirements around using controlled substances in pharmaceutical ... As their international operations expand and become increasingly complex, ... as a result of the first phase of the ...
(Date:1/22/2015)... 2015   Cypher Genomics, Inc., the leading ... SQNM ), the leading molecular diagnostics company, ... noninvasive prenatal tests (NIPT). Through this agreement, Sequenom ... to advance analysis of clinically-relevant fetal sub-chromosomal variants ...
(Date:12/25/2014)... The report “Service Quality Management and Telco ... Type - Global Advancements, Worldwide Forecasts & Analysis (2014-2019)” ... and forecasting of revenues. , Browse 152 market ... in-depth TOC on “Service Quality Management (SQM) and Telco ...
(Date:12/24/2014)...   BioLife Solutions , Inc. (NASDAQ: BLFS ), ... hypothermic storage and cryopreservation freeze media ... tissues  ("BioLife" or the "Company"), today announced that it will ... 2015 (the "Annual Meeting"). Because the expected date ...
Breaking Biology Technology:Global Compliance Service for Controlled Substances to Expand to China 2Cypher Genomics and Sequenom Announce Development Agreement 2Cypher Genomics and Sequenom Announce Development Agreement 3Cypher Genomics and Sequenom Announce Development Agreement 4Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4BioLife Solutions Sets Date for Annual Meeting of Stockholders 2
... HARBIN, China, Sept. 14 /PRNewswire-Asia-FirstCall/ -- ... ... ... keyed by longUrl, so we need to grab the first one. for (var r in data.results) { ...
... Optimer Pharmaceuticals, Inc. (Nasdaq: OPTR ... American and European fidaxomicin Phase 3 clinical trials ... (CDI) was presented at the 50th Annual Interscience ... Boston. (Logo: http://photos.prnewswire.com/prnh/20090413/LA97352LOGO ) ...
... CRANBURY, N.J., Sept. 14 Innophos Holdings, Inc. (Nasdaq: ... today announced that Randy Gress, Chief Executive Officer, will address ... September 30, 2010 at 8:00 a.m. (Eastern Time).   ... event, please go to www.innophos.com Investor Relations Events ...
Cached Biology Technology:Weikang Bio-Technology Issues 2010 and 2011 Fiscal Year Guidance 2Weikang Bio-Technology Issues 2010 and 2011 Fiscal Year Guidance 3Weikang Bio-Technology Issues 2010 and 2011 Fiscal Year Guidance 4Weikang Bio-Technology Issues 2010 and 2011 Fiscal Year Guidance 5Weikang Bio-Technology Issues 2010 and 2011 Fiscal Year Guidance 6Weikang Bio-Technology Issues 2010 and 2011 Fiscal Year Guidance 7Weikang Bio-Technology Issues 2010 and 2011 Fiscal Year Guidance 8Optimer Announces Presentation of Additional Data from Fidaxomicin Phase 3 Study for the Treatment of Clostridium difficile Infection (CDI) Presented at ICAAC 2Optimer Announces Presentation of Additional Data from Fidaxomicin Phase 3 Study for the Treatment of Clostridium difficile Infection (CDI) Presented at ICAAC 3Optimer Announces Presentation of Additional Data from Fidaxomicin Phase 3 Study for the Treatment of Clostridium difficile Infection (CDI) Presented at ICAAC 4Optimer Announces Presentation of Additional Data from Fidaxomicin Phase 3 Study for the Treatment of Clostridium difficile Infection (CDI) Presented at ICAAC 5Optimer Announces Presentation of Additional Data from Fidaxomicin Phase 3 Study for the Treatment of Clostridium difficile Infection (CDI) Presented at ICAAC 6Optimer Announces Presentation of Additional Data from Fidaxomicin Phase 3 Study for the Treatment of Clostridium difficile Infection (CDI) Presented at ICAAC 7
Vybrant® Multidrug Resistance Assay Kit...
...
... The CultureWell cell culture systems ... cultured cells for staining and imaging. ... preassembled with standard optical-quality coverslips in ... is provided sterile and ready to ...
... product contains 5 ml of DETACHaBEAD Mouse ... mouse CD4+ T cells from Dynabeads Mouse ... CD4+ T cells from Dynabeads Mouse CD4 ... are suitable for any downstream application including ...
Biology Products: