Navigation Links
Researchers find new hope for treatment of chronic leukemia
Date:8/17/2011

Wednesday, August 17, 2011, Cleveland: While testing a new drug designed to treat chronic leukemia, researchers at Cleveland Clinic discovered new markers that could identify which patients would receive maximum benefit from the treatment.

This information was released in the online edition of Blood, a weekly medical journal published by the American Society of Hematology.

Chronic lymphocytic leukemia (CLL), a cancer of the white blood cells that is incurable with standard treatment, is the most common type of leukemia in the Western Hemisphere. Conventional chemotherapy is effective at controlling CLL for many years, but the disease always relapses. CLL is characterized by an uncontrolled cell growth and division due to a defect in a process called programmed cell death, or apoptosis. A group of proteins called the Bcl-2 family is responsible for this defect.

Alex Almasan, Ph.D., a researcher in the Lerner Research Institute (LRI) of Cleveland Clinic in close collaboration with other researchers in both LRI and the Taussig Cancer Institute of Cleveland Clinic collected blood samples from patients with CLL and tested the ability of a new drug to kill the cancerous cells. The drug, Navitoclax, is already in early stage clinical testing for patients with CLL. Navitoclax appears to be effective for some patients, and until this research study, there had been no clear way to predict who will respond to its effects.

In addition, these studies can be informative to the currently ongoing clinical trials with Navitoclax in other hematologic malignancies or solid tumors.

"Follow-up studies on patients that have been treated with Navitoclax, particularly those that are poor responders, could determine whether the Bcl-2 family genes examined in this study may also be important for development of resistance to this agent," said Almasan.


'/>"/>

Contact: Dan Doron
dorond@ccf.org
216-312-0428
Lerner Research Institute
Source:Eurekalert

Page: 1

Related biology news :

1. Researchers find way to align gold nanorods on a large scale
2. UBC researchers discover key mechanism that regulates shape and growth of plants
3. Researchers discover oldest evidence of nails in modern primates
4. Researchers map pathway of infection for a common, potentially life-threatening respiratory virus
5. Researchers demonstrate green tea is effective in treating genetic disorder and types of tumors
6. Researchers discover freshwater mussel species thought to be extinct
7. NYU Langone researchers identify a signaling pathway as possible target for cancer treatment
8. Toronto researchers first to discover new genetic clue in the development of rheumatoid arthritis
9. Researchers decode workings of mysterious, but critical TB drug
10. Researchers fight cholera with computer forecasting
11. Vanderbilt researchers, international team, uncover genes linked to multiple sclerosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... , July 11, 2014 Research and ... "International Biometrics Technology Market - Industry Analysis Size Share ... their offering. http://photos.prnewswire.com/prnh/20130307/600769 ... crimes has created a need for high level security ... for personnel authentication such as username and passwords, tokens ...
(Date:7/11/2014)... the brains of all vertebrates, information is transmitted ... or chemical signal to be passed from one ... the most abundant type of synapse, can be ... for learning, memory, perception and cognition, and the ... brain function. For instance, every time we ...
(Date:7/10/2014)... 27, 2014  The American Academy of Forensic ... Standards and Technology (NIST) and the Department of ... and forensic science expert members to the Forensic ... element of the NIST,s Organization of Scientific Area ... first appointments made to the new FSSB that ...
Breaking Biology News(10 mins):International Biometrics Technology Market - Industry Analysis Size Share Growth Trends and Forecast to 2019 2Blame it on the astrocytes 2Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 2Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 3
... A recent report in Cancer Discovery , ... suggests that a new treatment may be on the ... of this disease. Mark Rubin, M.D., professor of ... said although fewer than 2 percent of men with ...
... large scale coastal development underway in the Middle East must ... degradation and losses in the fragile marine ecosystems shared by ... Saudi Arabia, and the United Arab Emirates warns a ... report, by UNU,s Canadian-based Institute for Water, Environment and Health, ...
... studies have linked vitamin D deficiency to an increased ... Medical Center Heart Institute shows that too much vitamin ... heart condition known as atrial fibrillation. Researchers at ... Healthcare system, studied more than 132,000 patients and found ...
Cached Biology News:Environmental troubles growing in Mid-East Gulf region due to rapid coastal development 2Environmental troubles growing in Mid-East Gulf region due to rapid coastal development 3Environmental troubles growing in Mid-East Gulf region due to rapid coastal development 4Environmental troubles growing in Mid-East Gulf region due to rapid coastal development 5Environmental troubles growing in Mid-East Gulf region due to rapid coastal development 6New study links excessive amounts of vitamin D to onset of atrial fibrillation 2New study links excessive amounts of vitamin D to onset of atrial fibrillation 3
(Date:7/10/2014)... Senior supply chain management executives from ... the challenges of “Reducing Cost, Lead Time, & Defects ... sourcing. Describing the partnership of the Bio Supply Management ... Institute ( SCMI) of the University of San ... the Kroc Institute of Peace and Justice in San ...
(Date:7/10/2014)... July 10, 2014 /PRNewswire-iReach/ -- Tute Genomics, ... today announced an agreement with Lineagen, Inc., ... Lineagen,s NextStep Dx PLUS.  Lineagen, focused ... neurological disorders, currently offers FirstStep Dx ... service used by healthcare providers as a ...
(Date:7/10/2014)... University of Adelaide research may help in the fight ... can detect tiny quantities of explosives with the use ... the journal Sensors and Actuators B: Chemical , ... can detect explosives in concentrations as low as 6.3 ... of only a few minutes. , "Traditionally explosives detection ...
(Date:7/10/2014)... observed the fractional quantum Hall effect in bilayer graphene ... be tuned by an electric field. , The ... confined to thin sheets are exposed to large magnetic ... thousands of individual electrons behave as a single system. ... well established, many details of this collective behavior remain ...
Breaking Biology Technology:Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 2Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 4Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 3Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 4Detecting trace amounts of explosives with light 2Columbia researchers observe tunable quantum behavior in bilayer graphene 2Columbia researchers observe tunable quantum behavior in bilayer graphene 3
... , LACHEN, SWITZERLAND and HOBOKEN, N.J., Sept. ... submitted its Biological License Application for octagam(R) 10% ... Food and Drug Administration (FDA) with the goal of ... 2010. The application was submitted for the treatment of Idiopathic Thrombocytopenic ...
... ... launched its revolutionary Trusted LASIK Surgeons directory service and website at ... vision and find a highly qualified LASIK surgeon who can help improve ... directory apart is a unique screening process ensuring that only those who ...
... fluid boils in tiny "microchannels" has led to formulas ... cool high-power electronics in electric and hybrid cars, aircraft, ... boil in cooling systems dramatically increases how much heat ... to below its boiling point, said Suresh Garimella, the ...
Cached Biology Technology:Octapharma Aims to Expand U.S. Immune Globulin Therapy Portfolio 2Octapharma Aims to Expand U.S. Immune Globulin Therapy Portfolio 3LASIK Surgery Specialist G. Brock Magruder, Jr., M.D. of LaserVue Lasik Center of Orlando Joins the Trusted LASIK Surgeons Directory 2LASIK Surgery Specialist G. Brock Magruder, Jr., M.D. of LaserVue Lasik Center of Orlando Joins the Trusted LASIK Surgeons Directory 3LASIK Surgery Specialist G. Brock Magruder, Jr., M.D. of LaserVue Lasik Center of Orlando Joins the Trusted LASIK Surgeons Directory 4LASIK Surgery Specialist G. Brock Magruder, Jr., M.D. of LaserVue Lasik Center of Orlando Joins the Trusted LASIK Surgeons Directory 5LASIK Surgery Specialist G. Brock Magruder, Jr., M.D. of LaserVue Lasik Center of Orlando Joins the Trusted LASIK Surgeons Directory 6LASIK Surgery Specialist G. Brock Magruder, Jr., M.D. of LaserVue Lasik Center of Orlando Joins the Trusted LASIK Surgeons Directory 7New findings could help hybrid, electric cars keep their cool 2New findings could help hybrid, electric cars keep their cool 3New findings could help hybrid, electric cars keep their cool 4
anti-JNK2 Immunogen: Recombinant human JNK2 protein Accession Number: NM_002752 Quality Assurance: Routinely evaluated by immunoblot. Molecular Weight: 46 and/or 54 kDa Available ...
Gloves are 9.25 long, latex, powder free, smooth and ambidextrous....
Request Info...
... Immunogen KLH-conjugated, synthetic ... 47-66 (PAEV-GPGAVGERTPRKKEPP) of human BRAF-HDAC ... (BHC110/LSD1). Quality Assurance ... Stability 2 years ...
Biology Products: