Navigation Links
Researchers find new gene linked to breast cancer
Date:10/7/2007

BRCA1 or HMMR can lead to genetic instability and interfere with cell division.

These findings made us wonder whether HMMR might also be a breast cancer susceptibility gene, says study author Stephen Gruber, M.D., Ph.D., M.P.H., the H. Marvin Pollard Professor of Internal Medicine at the U-M Medical School. Gruber is an associate professor of internal medicine and of human genetics in the U-M Medical School, and of epidemiology in the U-M School of Public Health. He directs the Cancer Genetics program in the U-M Comprehensive Cancer Center, which focuses on inherited cancer risks.

To understand whether variation in HMMR increases breast cancer risk, the researchers looked at the genes of 923 Jewish Israeli women with breast cancer and similar women without breast cancer in a study led by Gadi Rennert, M.D., director of the CHS National Cancer Control Center in Haifa, Israel. The Ashkenazi Jewish population in Israel carries a higher risk of breast cancer than other ethnicities.

This component of the study found that women with a variation in the HMMR gene had a higher risk of breast cancer, even after accounting for mutations in the BRCA1 or BRCA2 genes. In particular, the risk of breast cancer in women under age 40 who carry the HMMR variation was 2.7 times the risk in women without this variation.

The researchers further verified the finding in a second group of Ashkenazi Jewish women in New York who had a family history of breast cancer but no identified BRCA1 or BRCA2 mutations and a third study of Jewish women with and without breast cancer in New York. In total, 2,475 women with breast cancer and 1,918 healthy women were studied in Israel and New York.

Overall, the risk of breast cancer was 23 percent higher in women who had one copy of genetic variant, and 46 percent higher in women who had inherited two copies. In addition, those women were diagnosed an average of 12 months younger than women from the control
'/>"/>

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. NYU researchers simulate molecular biological clock
5. Researchers reveal the infectious impact of salmon farms on wild salmon
6. Researchers identify target for cancer drugs
7. Vital step in cellular migration described by UCSD medical researchers
8. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
9. UCSD researchers maintain stem cells without contaminated animal feeder layers
10. Researchers discover molecule that causes secondary stroke
11. Researchers find missing genes of ancient organism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... suggests that the effects of a commonly used anesthetic ... , The study, published in this week,s issue of ... biologists at the University of California, San Diego and ... to concerns, arising from multiple studies on humans over ... may increase their susceptibility to long-term cognitive and behavioral ...
(Date:7/28/2014)... identified areas of the Earth that are high priorities ... Europe is particularly vulnerable, as it has the lowest ... of any continent in ,refugia, areas of biological ... remain relatively constant during times of great environmental change. ... in Scandinavia and Scotland. , The biggest refugia ...
(Date:7/28/2014)... that can help advance the genetic engineering of ... has been developed by researchers with the U.S. ... a multi-institutional partnership led by Lawrence Berkeley National ... an assay that enables scientists to identify and ... components in the biosynthesis of plant cell walls. ...
Breaking Biology News(10 mins):Study suggests disruptive effects of anesthesia on brain cell connections are temporary 2Study suggests disruptive effects of anesthesia on brain cell connections are temporary 3Study finds Europe's habitat and wildlife is vulnerable to climate change 2How sweet it is 2How sweet it is 3
... aspires to a lifetime of addiction. But their brains ... journal Neuropsychopharmacology this week, Rockefeller University researchers ... can sustain lifelong and permanent changes in their reward ... and make such adolescents more vulnerable to the drug,s ...
... of Palm Vein Authentication Technology with, Single-Sign On Solutions ... ... Passwords, SUNNYVALE, Calif., Sept. 9 Fujitsu Computer ... products including,hard disk drives, peripherals and biometric security solutions, ...
... novel way to improve survival and recovery rate after ... Stem Cell Research by scientists at Singapore,s Institute ... and The Netherlands, University Medical Center Utrecht. ... the first non-cell based therapeutic application of human embryonic ...
Cached Biology News:Abuse of painkillers can predispose adolescents to lifelong addiction 2Fujitsu Announces PalmSecure(TM) LOGONDIRECTOR 2Fujitsu Announces PalmSecure(TM) LOGONDIRECTOR 3Fujitsu Announces PalmSecure(TM) LOGONDIRECTOR 4Human embryonic stem cell secretions minimized tissue injury after heart attack 2Human embryonic stem cell secretions minimized tissue injury after heart attack 3
(Date:7/28/2014)... It’s a hard truth: Nearly half of recent veterans who ... are failing to obtain a diploma or certificate within a ... an analysis by The Resume Place , a major ... college majors, which leads to underemployment, unemployment or just plain ... of post-9/11 veterans using GI Bill education benefits ...
(Date:7/28/2014)... DUBLIN , July 28, 2014 Research ... "Global Particle Size Analysis Market 2014-2018" report to their ... Particle size analysis is a technique used to determine ... powder or liquid. It is crucial to analyze the size ... material. Therefore, particle size analysis is performed to determine the ...
(Date:7/25/2014)... , July 25, 2014 Amgen (NASDAQ: ... Directors today declared a $0.61 per share dividend for ... paid on Sept. 5, 2014, to all stockholders of ... 14, 2014.  About Amgen Amgen is ... suffering from serious illnesses by discovering, developing, manufacturing and ...
(Date:7/25/2014)... July 25, 2014 According to a ... Drugs Market - Global Industry Analysis, Size, Share, Growth, ... drugs market is estimated at USD 161,056.5 million in ... of 10.1% from 2014 to 2020, to reach an ... The biological drugs market is witnessing a significant growth ...
Breaking Biology Technology:Resume Place: To Choose the Best College Majors, Veterans Need Early Career Counseling, Data Shows 2Resume Place: To Choose the Best College Majors, Veterans Need Early Career Counseling, Data Shows 3Resume Place: To Choose the Best College Majors, Veterans Need Early Career Counseling, Data Shows 4Global Particle Size Analysis Market 2014-2018 2Amgen Announces 2014 Third Quarter Dividend 2Amgen Announces 2014 Third Quarter Dividend 3Biological Drugs Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 2Biological Drugs Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 3
... Registry reveals that 70% of deaths in the stable stroke ... other than stroke, NICE, France, May 15 New ... Congress, highlight that among,those who die after a stroke the ... overall death rate is 4.45%, with,3.23% of these CV deaths ...
... , Chinese researchers have recently made a golden ... is a large ring-shaped molecule containing 36 gold atoms. The ... Universities of Beijing, Hong Kong, and Nanjing report their unusual ... is held together exclusively by goldgold bonds and is thus ...
... opportunities for micro and nano technologies. These challenges are ... the control and understanding of their behaviour. , This ... fibre analysis at the micro and nano-scale using state-of-the ... techniques. , Topics include fundamental effects of topography in ...
Cached Biology Technology:Stable Stroke Patients More Likely to Die From a Nonstroke Cardiovascular Event Than a Further Stroke 2Stable Stroke Patients More Likely to Die From a Nonstroke Cardiovascular Event Than a Further Stroke 3Stable Stroke Patients More Likely to Die From a Nonstroke Cardiovascular Event Than a Further Stroke 4Stable Stroke Patients More Likely to Die From a Nonstroke Cardiovascular Event Than a Further Stroke 5Golden nanocrown 2Micro and Nano Scale Characterization of Fibers 2
EML1 (K-16)...
Bovine Renal Artery Endothelial Cells (BRAEC) (>500,000 cells)...
Bovine Brain Microvascular Endothelial Cells (BBMVEC) (>500,000 cells)...
... ,• Eliminates nonspecific products due to ... specificity allows extension through DNA regions which ... Leaves an 'A' overhang ,TEMPase II ... DNA Polymerase that remains inactive at ...
Biology Products: