The liver is one of the few organs in our body that can regenerate itself, but how it occurs is a biological mystery. New research from BRIC, University of Copenhagen and the Finsen Laboratory, Rigshospitalet, has identified a protein complex that acts as a molecular switch turning on a self-regeneration program in the liver. The protein complex furthermore fine tunes liver metabolism, allowing this to run efficiently in parallel with the tissue damage repair. The new knowledge challenges the current focus on stem cells and may point towards future simplification of treatments used for repairing tissue damage.
"Our new data challenge the predominant 'stem cell-mania' as the results reveal important molecular mechanisms that enable ordinary liver cells to divide and repair tissue damage. This may point to ways of using ordinary liver cells for therapeutic purposes, as these cells may be easier to use than stem cells," says Head of Clinic and Professor Bo Porse who has lead the investigation.
Turning on self-renewal genes
When the specialised cell types of our body are formed from stem cells during development, they generally lose the ability to divide and make new cells. Tissue renewal is therefore a job for the stem cells present in our body. One exception is the specialised cells of the liver called hepatocytes. They are responsible for the metabolic functions of the liver, but can at the same time produce new liver cells. How that is possible is a bit of a mystery.
"Our results show how a protein complex is changed upon damage to the liver, making it function as a 'switch' turning on a self-renewal program in the hepatocytes. The protein complex literally turns on selected genes that enable division of the hepatocytes, while maintaining their metabolic functions," says postdoc Janus Schou Jakobsen, who has lead the experimental part of the investigation.
The extraordinary ability of the liver cells to divi
|Contact: Bo Porse|
University of Copenhagen