Navigation Links
Researchers find molecular switch turning on self-renewal of liver damage
Date:3/7/2013

The liver is one of the few organs in our body that can regenerate itself, but how it occurs is a biological mystery. New research from BRIC, University of Copenhagen and the Finsen Laboratory, Rigshospitalet, has identified a protein complex that acts as a molecular switch turning on a self-regeneration program in the liver. The protein complex furthermore fine tunes liver metabolism, allowing this to run efficiently in parallel with the tissue damage repair. The new knowledge challenges the current focus on stem cells and may point towards future simplification of treatments used for repairing tissue damage.

"Our new data challenge the predominant 'stem cell-mania' as the results reveal important molecular mechanisms that enable ordinary liver cells to divide and repair tissue damage. This may point to ways of using ordinary liver cells for therapeutic purposes, as these cells may be easier to use than stem cells," says Head of Clinic and Professor Bo Porse who has lead the investigation.

Turning on self-renewal genes

When the specialised cell types of our body are formed from stem cells during development, they generally lose the ability to divide and make new cells. Tissue renewal is therefore a job for the stem cells present in our body. One exception is the specialised cells of the liver called hepatocytes. They are responsible for the metabolic functions of the liver, but can at the same time produce new liver cells. How that is possible is a bit of a mystery.

"Our results show how a protein complex is changed upon damage to the liver, making it function as a 'switch' turning on a self-renewal program in the hepatocytes. The protein complex literally turns on selected genes that enable division of the hepatocytes, while maintaining their metabolic functions," says postdoc Janus Schou Jakobsen, who has lead the experimental part of the investigation.

The extraordinary ability of the liver cells to divi
'/>"/>

Contact: Bo Porse
bo.porse@bric.ku.dk
(45) 35-45-60-23
University of Copenhagen
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. UGA researchers shed light on ancient origin of life
2. Researchers discover workings of brains GPS system
3. Researchers propose new solution to ensure biofuel plants dont become noxious weeds
4. Temple researchers discover key to heart failure, new therapies on horizon
5. Researchers discover gene that causes obesity in mice
6. U of M researchers utilize genetically corrected stem cells to spark muscle regeneration
7. Researchers id queens, mysterious disease syndrome as key factors in bee colony deaths
8. Study led by NUS researchers proves the existence of 3 overstretched DNA structures
9. U of M researchers identify genetic variation behind acute myeloid leukemia treatment success
10. 3 Johns Hopkins researchers recognized for medical inventions
11. University of Alberta researchers bake a better loaf of bread
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers find molecular switch turning on self-renewal of liver damage
(Date:4/17/2014)... that fish consumption advisories for expecting mothers are ... like persistent organic pollutants (POPs). , The ... University of Toronto Scarborough PhD student Matt Binnington ... levels of environmental contamination, a mother,s compliance with ... body influenced exposure in her children. , Their ...
(Date:4/17/2014)... A Kansas State University engineer has developed ... remotely detects improvised explosive devices. The same technique ... Dunn, the Steven M. and Kay L. Theede ... and nuclear engineering, and his research team have ... underground or in car trunks. The distance detection ...
(Date:4/17/2014)... in Europe, Asia and the United States are spreading ... impacting native honeybee populations at this time, according to ... including Nosema microsporidia and Varroa ... to these invasive pests, which suggests to us that ... and the United States currently are not necessary in ...
Breaking Biology News(10 mins):Fish consumption advisories fail to cover all types of contaminants 2Patented research remotely detects nitrogen-rich explosives 2East African honeybees are safe from invasive pests… for now 2East African honeybees are safe from invasive pests… for now 3
... who are especially reactive to stress are more vulnerable ... than their peers. But a new longitudinal study suggests ... do well when they,re raised in supportive environments. ... Columbia, the University of California, San Francisco, and the ...
... scientists at Rice University have discovered a new technique ... with tiny explosions. The scientists used lasers to make ... on cancer cells, they found they could tune the ... visible but harmless or large bubbles that burst the ...
... conducted at the University of Maryland,s bat lab shows Egyptian ... sonar directly at it. Instead, they alternately point the sound ... by researchers from Maryland and the Weizmann Institute of Science ... to pinpoint the location of a target, but also makes ...
Cached Biology News:High sensitivity to stress isn't always bad for children 2Rice physicists kill cancer with 'nanobubbles' 2'Zen' bats hit their target by not aiming at it 2'Zen' bats hit their target by not aiming at it 3
(Date:1/15/2014)... and SAN JOSE, California , ... biotechnology company developing antibody-drug conjugates for cancer, today announced the ... of Directors. Dr Reynolds has over 20 years, development experience ... Officer at Seattle Genetics. "I am delighted to ...
(Date:1/15/2014)... 15, 2014 More than 5 million ... 1 in 3 seniors will die with Alzheimer’s or ... jaw-dropping figures have shocked many Americans into looking for ... prevent these tragic age-related cognitive disorders. Jonathan Weisman, president ...
(Date:1/15/2014)... January 15, 2014 2013 was a ... Brain State Technologies®. They saw continued independent research led ... who were awarded a $1 million grant from the ... “Brain and Behavior” a peer reviewed journal, Amy Grant ...
(Date:1/14/2014)... Date: Friday, April 11, 2014 , Time: 6 p.m. ... Road, Warrington, Pa. , Details: The Hepatitis B ... a cure for hepatitis B and improving the quality of ... Ball on Friday, April 11 at Warrington Country Club in ...
Breaking Biology Technology:Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 3Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2
... love this provider of really useful, reliable, and not to mention ... fact came to light a few weeks ago when the Internet ... gourmet chefs to prepare meals (free to employees) for its brainy ... will soon be leaving to start a chain of natural foods ...
... all the time. A company hires an independent computer programmer ... uses to run an important part of its business. All ... ,Even when there is a written contract, the specifics of ... not addressed. , ,Years later (perhaps as a result of ...
... Wis. -- Researchers at the USDA Forest Service ... agencies and the pulp and paper industry in an ... of the paper commonly used in business and government ... , ,The federal government annually buys some 500,000 tons ...
Cached Biology Technology:Is Google's cafeteria a competitive weapon? 2Is Google's cafeteria a competitive weapon? 3Is Google's cafeteria a competitive weapon? 4Who owns software developed for your company? 2Who owns software developed for your company? 3Who owns software developed for your company? 4Reducing brightness to make a better paper 2Reducing brightness to make a better paper 3
... Ion Trap Time of Flight Mass Analyzer for superior sensitivity, mass ... 100 - 25,000 m/z, * Precursor ion selection range: 150 - ... accuracy: 5 ppm with internal reference, * Dynamic range: 4 orders ... ...
... Yeast Display Vector is specifically designed to ... surface of Saccharomyces cerevisiae. Displayed proteins can ... with known or putative ligands. pYD1 uses ... of two domains, Aga1 and Aga2, to ...
... pleiotropic cytokine produced by activated T cells, ... the growth of some tumour and normal ... Kaposis sarcoma cell proliferation, cytokine release from ... expression on hepatoma cells. Mouse OSM was ...
Mouse polyclonal antibody to BTAF1 - BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (Mot1 homolog, S. cerevisiae)...
Biology Products: