Navigation Links
Researchers find hormone that predicts premature death in kidney patients
Date:9/8/2011

AURORA, Colo. (Sept. 9, 2011) Researchers at the University of Colorado School of Medicine have found that high levels of a specific hormone can predict which kidney patients will develop heart problems, require dialysis or die prematurely.

"This discovery allows us to predict at-risk patients before they require dialysis," said lead investigator Michel Chonchol, MD, an associate professor of medicine specializing in nephrology. "That's critical because approximately 23 percent of patients on dialysis die in the first year."

The findings were published Friday in the Journal of the American Society of Nephrology.

Chonchol and fellow CU School of Medicine researcher Jessica Kendrick, MD, studied the blood plasma of patients with advanced kidney disease and found that levels of fibroblast growth factor-23, a hormone known as FGF-23, increased as the patient's kidney function decreased.

The hormone regulates phosphorous levels in the body. As the kidneys fail, they are unable to excrete phosphorous which raises FGF-23 levels. The higher the hormone levels, the greater chance the patient will die.

"At this point we don't know how the hormone changes the body," Chonchol said.

By the time a patient is down to just 30 or 40 percent kidney function, the levels of FGF-23 can predict who will die, have a cardiac event or end up on dialysis. Almost 50 percent of the deaths result from cardiovascular issues like heart attack.

Until now, doctors relied on measuring phosphorous to assess phosphate balance in patients with kidney disease.

"Prior to a patient going on dialysis the phosphorous levels shoot up," Chonchol said.

But he found that long before phosphorous levels jump, FGF-23 levels have already increased. Identifying this earlier will allow doctors to intervene with drugs that can lower phosphorous which would then lower the hormone level.

"This has provided us a critical marker to look for," Chonchol said, "A marker that could save lives."

Kidney disease currently afflicts 20 million Americans and is a growing problem as the nation gets increasingly obese and diabetes continues to rise.

"The best ways to prevent kidney disease is through blood pressure control, diet, exercise and maintaining a healthy body weight," Chonchol said.


'/>"/>

Contact: David Kelly
david.kelly@ucdenver.edu
303-315-6374
University of Colorado Denver
Source:Eurekalert

Related biology news :

1. NC State researchers get to root of parasite genome
2. Researchers find animal with ability to survive climate change
3. Researchers find an essential gene for forming ears of corn
4. Researchers note differences between people and animals on calorie restriction
5. Researchers study acoustic communication in deep-sea fish
6. Researchers discover that growing up too fast may mean dying young in honey bees
7. Researchers study how pistachios may improve heart health
8. UI researchers find potentially toxic substance present in Chicago air
9. Researchers develop new self-training gene prediction program for fungi
10. Case Western Reserve University researchers track Chernobyl fallout
11. Childrens National researchers develop novel anti-tumor vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/14/2016)... HANOVER , Allemagne, March 14, 2016 /PRNewswire/ ... http://www.apimages.com ) - --> - ... ) - --> ... les solutions biométriques, fournit de nouveaux lecteurs d,empreintes ... lecteur LF10 de DERMALOG sera utilisé pour produire ...
(Date:3/11/2016)... -- --> --> ... Market by Technology (Pattern Recognition), by Component (Hardware, Software, ... (On-Premises and Cloud), by Industry Vertical and by Region ... global market is expected to grow from USD 12.49 ... at a CAGR of 19.1%. , ...
(Date:3/10/2016)... March 10, 2016   Unisys Corporation (NYSE: ... Protection (CBP) is testing its biometric identity solution at ... to help identify certain non-U.S. citizens leaving the ... test, designed to help determine the efficiency and accuracy of ... February and will run until May 2016. --> ...
Breaking Biology News(10 mins):
(Date:5/25/2016)... Calif. (PRWEB) , ... May 25, 2016 , ... Lajollacooks4u ... area and has consistently been rated one of its top attractions. Fortune 500 ... globe to participate in a unique and intimate team-building experience. , Each event kicks ...
(Date:5/25/2016)... ... May 25, 2016 , ... Founder of the Fitzmaurice ... surgery and surgery of the hand by the National Board of Physicians and ... above and beyond in his pursuit of providing the most comprehensive, effective treatment ...
(Date:5/25/2016)... ... May 25, 2016 , ... WEDI, the nation’s leading ... today announced that Charles W. Stellar has been named by the WEDI Board of ... January 2016. As an executive leader with more than 35 years of experience in ...
(Date:5/24/2016)... ... May 24, 2016 , ... Cell ... injuries, will be accelerated by research at Worcester Polytechnic Institute (WPI) that yielded ... healing and tissue regeneration. , The novel method, developed by WPI faculty members ...
Breaking Biology Technology: