Navigation Links
Researchers find gene responsible for neurodegenerative disease in dogs, possibly in humans
Date:8/24/2010

A North Carolina State University researcher has helped to locate and identify a gene responsible for a fatal neurodegenerative disease that affects American Staffordshire terriers. This same gene may be responsible for a similar rare, fatal disease in humans. Its discovery will lead to improved screening and diagnosis of the disease in dogs and is the first step in working toward a cure for both canines and humans.

Dr. Natasha Olby, associate professor of neurology, was part of a multi-national team of researchers who located the gene responsible for a variant of neuronal ceroid lipofuscinoses (NCL), a family of diseases that result in mental and motor deterioration and eventually death in the dogs.

The team's results were published in the Aug. 17 issue of the Proceedings of the National Academy of Sciences.

NCLs, while rare in humans, are most common in children, although an adult-onset form of the disease known as Kufs' disease does occur. In this adult disease, neurons within the brain gradually die, causing loss of vision, epilepsy, dementia and loss of coordination.

Olby saw the first case of a canine version of adult-onset NCL in American Staffordshire terriers in 2000. Over subsequent years, she found that the disease was a widespread and hereditary problem within the breed, affecting one of every 400 registered dogs. The disease kills the neurons in the cerebellum, which controls balance. Over time, the cerebellum shrinks, motor control deteriorates, and the patient dies or is euthanized.

"The disease became so prevalent because it was a recessive disease with a late onset," says Olby. "Carriers of a single copy of the mutated gene never develop symptoms, and dogs with two copies of the gene might not show symptoms until five or six years of age, so the mutation was able to take hold in the breeding population."

Through genetic analysis, the research group was able to locate the specific
'/>"/>

Contact: Tracey Peake
tracey_peake@ncsu.edu
919-515-6142
North Carolina State University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers study cinnamon extracts
2. K-state researchers explore physiological effects of space travel with NASA grant
3. Researchers connect APC protein to autism and mental retardation
4. MIT researchers develop a better way to grow stem cells
5. U of M researchers identify 2 FDA approved drugs that may fight HIV
6. Researchers advance understanding of enzyme that regulates DNA
7. Juelich researchers take a look inside molecules
8. Researchers: Cures to diseases may live in our guts
9. Researchers discover how the storehouses of plant cells are formed
10. Mount Sinai researchers discover new mechanism behind cellular energy conversion
11. ISU researchers discover cause of immune system avoidance of certain pathogens
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/11/2014)... 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/twhjll/biometrics_market ) has announced the addition of ... 2015-2019"  report to their offering. ... advances in technology. With continuous advances in technology, ... the latest standard that meets the needs and ...
(Date:12/10/2014)... Dec. 8, 2014 You,ve been here before: you ... can,t remember your password, site key or the answer to ... first grade teacher? Today, Hoyos Labs ... app that will finally put an end to the frustration ... TM . 1U leverages a user,s smartphone to acquire ...
(Date:12/10/2014)... --Research and Markets ( http://www.researchandmarkets.com/research/xclcvw/biometrics_market ) ... Market in Japan 2014-2018" report to their ... The integration of biometrics and smart ... upgradation of the driver,s license is one of ... the aforementioned projects, biometrics is being used as ...
Breaking Biology News(10 mins):Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2
... seaweed which helps to create a protective physical barrier ... an effective antiviral in the treatment of the common ... against influenza viruses, including the pandemic H1N1 influenza strain. ... viruses, effectively blocking the virus from attaching to cells ...
... in Canada is revealing how plants struggled to endure a ... by a landslide and exquisitely preserved 2 to 8 million ... will respond to global warming. They also suspect that ... Arctic ice continues to melt. As the wood is exposed ...
... Athens, Ga. University of Georgia researchers have ... of pneumonia within minutes, potentially replacing existing tests that ... researchers, whose findings are detailed online in the journal ... atypical or "walking pneumonia," in true clinical samples with ...
Cached Biology News:Ancient forest emerges mummified from the Arctic 2Ancient forest emerges mummified from the Arctic 3UGA researchers develop rapid diagnostic test for common type of pneumonia 2
(Date:12/24/2014)... AUSTIN, Texas , Dec. 24, 2014 /PRNewswire/ ... company focused on gynecologic disease, announced today that ... with investors including Oracle Investment Management, Jack ... Vermillion directors. Total proceeds were $10.5 million, before ... working capital and general corporate purposes. ...
(Date:12/24/2014)... (PRWEB) December 23, 2014 GMO corn ... biotechnology company, Syngenta, are in the process of being ... The consolidated case is In Re: Syngenta AG MIR ... District Court for the District of Kansas. , Management ... been handed over to U.S. District Judge John W. ...
(Date:12/24/2014)... (PRWEB) December 23, 2014 On ... law H.R. 83, the Omnibus and Continuing Resolution ... time, made hydrocephalus a condition eligible to receive ... (CDMRP) administered by the Department of Defense (DoD). ... its allies on Capitol Hill, is celebrating this ...
(Date:12/24/2014)... Nashville Fertility Center announced that Dr. George ... Society for Reproductive Medicine (ASRM), a leading professional organization ... In his new role as treasurer, Dr. Hill ... will have a voice in furthering the mission of ... since 1984 when he joined while conducting fellowship training ...
Breaking Biology Technology:Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3Carey Danis & Lowe Reports on Syngenta GMO Corn Transfer Order 2Rare Brain Condition Now Eligible for Department of Defense Research Dollars 2Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 2Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 3
... , , , , , The BioRobot ... designed to meet the needs , of scientists requiring standardized protocols in environments such ... , , ... , , Standardized ...
... , , , , , , ... Welcome to the third of a series of articles providing useful hints for ... cell culture conditions. The series will continue in future issues of QIAGEN , ... , , Media ...
... , , , , , ... , , , , , , ... is a powerful and sensitive technique , used by scientists ... mix and thermal cycling conditions can be adjusted to use almost any DNA , ...
Cached Biology Technology:BioRobot MDx standardize your automated protocols in clinical , laboratories 2BioRobot MDx standardize your automated protocols in clinical , laboratories 3BioRobot MDx standardize your automated protocols in clinical , laboratories 4BioRobot MDx standardize your automated protocols in clinical , laboratories 5The QIAGEN Guide to Animal Cell Culture 2The QIAGEN Guide to Animal Cell Culture 3Using the TripleMaster PCR System for Robust Amplification of , GC-Rich DNA Templates 2Using the TripleMaster PCR System for Robust Amplification of , GC-Rich DNA Templates 3Using the TripleMaster PCR System for Robust Amplification of , GC-Rich DNA Templates 4Using the TripleMaster PCR System for Robust Amplification of , GC-Rich DNA Templates 5Using the TripleMaster PCR System for Robust Amplification of , GC-Rich DNA Templates 6Using the TripleMaster PCR System for Robust Amplification of , GC-Rich DNA Templates 7Using the TripleMaster PCR System for Robust Amplification of , GC-Rich DNA Templates 8Using the TripleMaster PCR System for Robust Amplification of , GC-Rich DNA Templates 9Using the TripleMaster PCR System for Robust Amplification of , GC-Rich DNA Templates 10Using the TripleMaster PCR System for Robust Amplification of , GC-Rich DNA Templates 11
... AVOID FREEZE/THAW CYCLES. An assay kit ... by Western blotting. PARP is an enzyme ... During apoptosis, PARP is cleaved by caspase-3. ... kDa to 85 kDa is a hallmark ...
... handy dispensers save space and ... hats, and other garb. They ... bins for small parts used ... Clear acrylic. Open-slot design for ...
... is expressed in g per ml and is ... pH 6.8, of a 1 mg per ml ... concentration to agglutinate a 2% suspension of human ... at 25 C. Preparation Note: Affinity ...
... dispensers save space and organize gloves, ... garb. They are the perfect benchtop ... in labs, processing and manufacturing. Clear ... the particles they attract. Open-slot design ...
Biology Products: