Navigation Links
Researchers find first evidence for a genetic cause for Barrett's oesophagus
Date:9/9/2012

also showing a likely association with BE; this suggests that genetic effects may partly underpin the epidemiological observation that obesity is a risk factor for BE."

He continued: "In man, the MHC region occurs on chromosome 6 and consists of 150 genes, of which at least 50 per cent have functions in immunity, auto-immune responses or surveillance. Finding a gene here suggests that the immune system is not under control and is in over-drive in patients with BE. This suggests that it could be controlled by anti-inflammatory agents."

The researchers plan to test another 10,000 patients in order to replicate these results and to see if they can find any other genes that can predict who will go on to develop BE.

"We now know that BE can be inherited like Crohn's or coeliac disease. We have shown that it is likely that the body's control of inflammation and subtle changes to repair mechanisms dictate predisposition to the disease. Our findings make it possible to screen people to predict who will progress to develop BE, and enable us to design new drugs to treat the condition. Given that reflux oesophagitis is the commonest medical condition in the Western adult population, affecting one in three people, these finding have a huge potential impact," concluded Professor Jankowski.

BE occurs in about two per cent of the population, with the highest risk among men over 50 years old in developed countries. The risk of developing oesophageal adenocarcinoma among people with BE has been estimated to be approximately 0.4-1 per cent a year. Oesophageal cancer is the eighth most common cancer worldwide with nearly 482,000 new cases diagnosed and about 406,500 deaths each year [3].


'/>"/>
Contact: Emma Mason
e.mason@qmul.ac.uk
Queen Mary, University of London
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
3. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
4. UNH researchers find African farmers need better climate change data to improve farming practices
5. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
6. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
7. Researchers print live cells with a standard inkjet printer
8. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
9. Researchers reveal how a single gene mutation leads to uncontrolled obesity
10. Researchers discover novel therapy for Crohns disease
11. New paper by Notre Dame researchers describes method for cleaning up nuclear waste
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... sick can take up residence in and on the ... troublesome symptom, according to new research at Washington University ... average, healthy individuals carry about five types of viruses ... BioMed Central Biology . The study is the first ... healthy people. , The research was conducted as ...
(Date:9/16/2014)... chunk of rock hit the Yukatan peninsula near the site ... 100 teratons of TNT. It left a crater more than ... and volcanism are widely accepted to have wiped out the ... But what happened to the plants on which the dinosaurs ... University of Arizona reveals that the meteorite impact that spelled ...
(Date:9/16/2014)... would likely increase oil sands extraction, according to 26 ... organization Near Zero. The results are detailed in the ... supporters and opponents of the pipeline. , ... significantly higher greenhouse gas emissions, with the exact amount ... report examines three main scenarios discussed by participants in ...
Breaking Biology News(10 mins):Healthy humans make nice homes for viruses 2Healthy humans make nice homes for viruses 3Meteorite that doomed the dinosaurs helped the forests bloom 2Meteorite that doomed the dinosaurs helped the forests bloom 3Keystone XL would likely raise oil sands production and greenhouse gas emissions 2
... release is available in German . , ... cannot tell us about their cognitive skills or give ... in Svante Paabo,s team at the Max Planck Institute ... DNA of Neanderthals, they have made some new and ...
... Low-density lipoprotein (LDL), a transporter of cholesterol, may also ... according to a report published online this week in ... LDL (nLDL) and the vascular endothelial growth factor receptor ... vessel formation. LDL is responsible for transporting cholesterol ...
... spot for Botswana, developed while reading the best-selling #1 ... chance to do any sleuthing of their own in ... Illinois scientist Karen Chapman-Novakofski acquired a Batswana doctoral student ... and nutrition of that country,s elderly. "In Botswana, ...
Cached Biology News:Red hair and freckles... 2U of I scientist does nutritional detective work in Botswana 2U of I scientist does nutritional detective work in Botswana 3
(Date:9/17/2014)... MA (PRWEB) September 17, 2014 ... Safety (ACRES) , a multi-stakeholder non-profit collaborative building ... efficiency in clinical research, today announced Phase 3 ... , Amir H. Kalali, Vice-President, ... and Arti Bajpai, President, Compliance and Quality Integration ...
(Date:9/16/2014)... NEW YORK , Sept. 16, 2014 This ... by the following Product Segments: Software, Hardware, and Biocontent. The ... Canada , Japan , ... Latin America , and Rest of World. Annual estimates ... Also, a seven-year historic analysis is provided for these markets. ...
(Date:9/16/2014)... , Sept. 16, 2014  Biocom, the association representing ... community, recognizes the 9 th Annual National Health ... of IT technologies in improving our health care system. ... is one of the world,s most vibrant hubs for ... mobile health applications to genomic testing to remote patient ...
(Date:9/16/2014)... COLUMBIA, Mo. From cell phones to cars ... everyday life. Scientists and technology companies constantly are ... Now, for the first time using a water-based ... created a long-lasting and more efficient nuclear battery ... as a reliable energy source in automobiles and ...
Breaking Biology Technology:Global Standards Initiative for Clinical Research Sites Advances 2Global Standards Initiative for Clinical Research Sites Advances 3Global Standards Initiative for Clinical Research Sites Advances 4Global Bioinformatics Industry 2Global Bioinformatics Industry 3Global Bioinformatics Industry 4Global Bioinformatics Industry 5Global Bioinformatics Industry 6Global Bioinformatics Industry 7Global Bioinformatics Industry 8Global Bioinformatics Industry 9Global Bioinformatics Industry 10Global Bioinformatics Industry 11Global Bioinformatics Industry 12Global Bioinformatics Industry 13Global Bioinformatics Industry 14Global Bioinformatics Industry 15Global Bioinformatics Industry 16Global Bioinformatics Industry 17Global Bioinformatics Industry 18Global Bioinformatics Industry 19Global Bioinformatics Industry 20Global Bioinformatics Industry 21Global Bioinformatics Industry 22Global Bioinformatics Industry 23Biocom Recognizes National Health IT Week 2
...   Hospitals, health systems to benefit,from ... and other,performance management solutions Elsevier ... products,and services, has struck an exclusive partnership with ... learning solutions for process,improvement. Elsevier will market ...
... carbon, has the potential to make consumer electronic devices ... shrinking scale of electronics, also make graphene difficult to ... In September 2010, a UCLA research team ... and were able to fabricate graphene transistors with unparalleled ...
... 2011 Pharmacyclics, Inc. (Nasdaq: PCYC ) ... agreements with various institutional investors and its CEO for ... in a registered direct offering at $8.85 per share, ... of the offering, before deducting expenses, are expected to ...
Cached Biology Technology:Elsevier Strikes Exclusive eLearning Partnership with The Quality Group 2Elsevier Strikes Exclusive eLearning Partnership with The Quality Group 3Elsevier Strikes Exclusive eLearning Partnership with The Quality Group 4UCLA team reports scalable fabrication of self-aligned graphene transistors, circuits 2Pharmacyclics Announces Results of Registered Direct Offering 2Pharmacyclics Announces Results of Registered Direct Offering 3
... Proteolytic degradation is critical to the ... and regulatory proteins as important and ... metabolism, heat shock and stress response, ... receptors and ion channels, cell cycle ...
Each Yeast-GFP clone represents an individual S. cerevisiae strain containing an open reading frame with a C-terminal Aequorea Victoria GFP (S65T) fusion tag....
... be used for the identification of potential biomarkers ... and other diseases. Due to the fact that ... it provides an attractive alternative to blood plasma ... ProteoSpin Urine Protein Concentration Micro Kit provides ...
... forces with the Mickle Laboratory Engineering Company ... This tissue sectioning system has been designed ... experiments and to be especially applicable to ... or from small organs. Its special features ...
Biology Products: