Navigation Links
Researchers find first evidence for a genetic cause for Barrett's oesophagus
Date:9/9/2012

in the sequence of single nucleotides the molecules, A, T, C or G that make up DNA in two chromosomes. They then tested these two single nucleotide polymorphisms (SNPs) in a further 4,500 patients.

"After these stages, the two SNPs on chromosomes 6p21 and 16q24 showed compelling evidence that they were associated with the development of Barrett's oesophagus," said Professor Jankowski. "This is the first time a genetic link has been shown. Our findings provide a basis for genetically screening 30 per cent of the Western population who get acid reflux to see which 10 to 20 per cent of them three per cent of the population overall will go on to develop BE. These genetic variations will also form the basis for developing new targets for therapy.

"Given that BE is known to be a precursor to oesophageal cancer, it is quite possible that these genetic variations could also be risk factors for developing the cancer and they may give us clues as to the biological mechanisms involved."

The researchers found that one of the genetic variations was close to a gene, FOXF1, which is known to be involved in the development of the gastrointestinal tract (the oesophagus, stomach and intestines), and the other to the major histocompatability complex (MHC) region where there are genes involved with the immune system, inflammation and the sense of smell.

"Our results provide direct evidence for a genetic cause for Barrett's oesophagus," said Professor Jankowski. "Although it's not completely clear yet what roles are played by the underlying genes, the location of one of the SNPs near to the gene FOXF1 suggests there may be structural factors in the stomach and oesophagus that predispose a person to develop the condition. This is consistent with evidence that a structural deficit, namely hiatus hernia, is known to be strongly associated with BE. We also found evidence to show that SNPs that are known to be associated with increased body weight were
'/>"/>

Contact: Emma Mason
e.mason@qmul.ac.uk
Queen Mary, University of London
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
3. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
4. UNH researchers find African farmers need better climate change data to improve farming practices
5. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
6. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
7. Researchers print live cells with a standard inkjet printer
8. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
9. Researchers reveal how a single gene mutation leads to uncontrolled obesity
10. Researchers discover novel therapy for Crohns disease
11. New paper by Notre Dame researchers describes method for cleaning up nuclear waste
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... is available in German . ... Norway and they are a common sight on the roads ... cars topped the list of new vehicle registrations for the ... in Germany, where electric vehicles claim only a small portion ... roads in Germany, only a mere 8000 are electric powered. ...
(Date:7/24/2014)... a virus living inside your gut that has gone ... by researchers at San Diego State University has found ... to a newly described virus, named crAssphage, which infects ... Bacteroidetes . This phylum of bacteria is thought ... diseases. The research appears today in Nature Communications ...
(Date:7/23/2014)... The U.S. Environmental Protection Agency (EPA) today ... the University of Massachusetts Amherst School of Public ... three-year, $700,000 Science to Achieve Results (STAR) grant ... by Native subsistence hunters in subarctic North America ... exposure and to provide culturally-relevant recommendations for mitigation. ...
Breaking Biology News(10 mins):Nano-supercapacitors for electric cars 2Nano-supercapacitors for electric cars 3Newly discovered gut virus lives in half the world's population 2Newly discovered gut virus lives in half the world's population 3Studying impacts of indoor air pollution on tribal communities 2Studying impacts of indoor air pollution on tribal communities 3
... is underway that hopes to use a patient's own immune ... immunotherapy, is a specialty procedure performed in only a handful ... Medical Center. , Julian A. Kim, M.D., chief of surgical ... grant from the National Institutes of Health for a five-year ...
... 12 surgeons and 21 surgical residents, video game skill ... a simulated surgery skills course, according to a report ... of the JAMA/Archives journals. , James C. Rosser Jr., ... colleagues asked 33 surgeons (21 residents and 12 attending ...
... new study has pinpointed a natural ingredient of human ... for human AIDS, from infecting immune cells and multiplying. ... progression of HIV to full-blown AIDS and—because it works ... to the development of another class of drugs in ...
Cached Biology News:Discovery of an HIV inhibitor in human blood points to new drug class 2Discovery of an HIV inhibitor in human blood points to new drug class 3
(Date:7/24/2014)... July 24, 2014  ECC West Africa, LLC (ECC) ... with University College Hospital (UCH) Ibadan Board of ... to finance, design, construct, and operate and maintain a ... . Under the first of the 4-phase project, ... and funding applications. UCH Ibadan intends to finance and ...
(Date:7/24/2014)... materialise. Yet, scientists are making progress in devising ... such approach relies on quantum dotsa kind of ... field. A new study demonstrates that changing the ... with electrical impulses can help better control them. ... used as quantum information units, which would produce ...
(Date:7/24/2014)... , July 24, 2014 Research and ... "Global Cell Culture Market 2014-2018" report to their ... Cell culture is the in vitro growth of ... research, cell studies, and biopharmaceutical production. Cell culture is ... Cell culture instruments and cell culture consumables are necessary ...
(Date:7/24/2014)... July 24, 2014 SRI International has been ... National Institute of Allergy and Infectious Diseases (NIAID), part ... development of potential therapies for HIV infection and AIDS. ... HIV and AIDS and the complications and opportunistic infections ... preventing sexual transmission of HIV. According ...
Breaking Biology Technology:ECC Signs a Contract for the Finance, Design, and Construction of a Premier Cancer Institute in Ibadan, Nigeria 2Global Cell Culture Market 2014-2018: Key Vendors are Becton, Dickinson and Co, EMD, GE Healthcare, Lonza Group, Sigma Aldrich and Thermo Fisher Scientific 2National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 2National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 3
... professor of materials science and engineering at Virginia ... the Friedrich Wilhelm Bessel Research Award presented by ... is for scholars, internationally renowned in their field, ... ago and who are expected to continue to ...
... Investor Uprising ( www.investoruprising.com ) has released "A Guide ... best biotech Exchange Traded Funds (ETFs) and mutual funds, ... Website. (Logo: http://photos.prnewswire.com/prnh/20110411/NY80781LOGO-a) "A ... market, identifying the leading biotech mutual funds and ETFs. ...
... 2011 Aaron Mitchell, managing principal at global management consulting ... consultants of 2011 by Consulting Magazine. Mitchell was recognized for ... over several years and during a major, recent product launch. ... the top consultants," said Mitchell, who has more than 10 ...
Cached Biology Technology:Virginia Tech's Kathy Lu receives Humboldt Foundation research award 2Investor Uprising Publishes Free Biotech Investment Report 2Investor Uprising Publishes Free Biotech Investment Report 3Managing Principal at ZS Associates Named One of Consulting Magazine's Top 25 Consultants of 2011 2