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Researchers find drug that stops progression of Parkinson's disease in mice
Date:3/8/2011

eurosurgical colleague Robert Breeze, MD, have done the operation in 61 patients, more than any other group in the world. The procedure can replace the need for drugs but even cell transplants do not prevent the progression of the disease.

Freed and Zhou are now looking for other drugs that might turn on the DJ-1 gene. One drawback of phenylbutyrate is that patients must take very large doses, 16 grams per day or 32 large tablets taken at frequent intervals. While the drug is approved by the FDA for treating a rare genetic disease in infants, whether it can stop Parkinson's in people remains to be seen.

But Zhou and Freed believe the discovery offers new hope for those suffering from Parkinson's disease.

"If we can say to someone that as of today we can stop your disease from getting worse, that would be a truly significant achievement," Freed said.


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Contact: David Kelly
david.kelly@ucdenver.edu
303-315-6374
University of Colorado Denver
Source:Eurekalert

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