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Researchers find chink in the armor of viral 'tummy bug'
Date:12/23/2008

es: 'sialidase-sensitive' and 'sialidase-insensitive' strains," he said.

The team used nuclear magnetic resonance spectroscopy, 3D modelling and cell-based assays to observe the interaction between the virus and host cells.

"We found that a human strain previously through insensitive to sialidase does in fact recognise and bind to sialic acid, but it is a sialic acid not accessible to sialidase treatment." Professor von Itzstein said.

"This reveals that there is a common chink in the armour of these rotaviruses.

"This discovery is the first step in designing a broad-spectrum drug able to exploit this weakness to combat many types of human and animal rotaviruses."


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Contact: Jeannette Langan
j.langan@griffith.edu.au
61-755-528-654
Research Australia
Source:Eurekalert

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