Navigation Links
Researchers find chink in the armor of viral 'tummy bug'
Date:12/23/2008

Researchers at Griffith University's Institute for Glycomics in collaboration with colleagues at the University of Melbourne have moved a step closer to identifying a broad spectrum treatment for the dreaded 'viral tummy bug' or rotavirus.

These highly-infectious viruses are the leading cause of severe diarrhoea in young children, responsible for thousands of hospitalisations in the developed world, and hundreds of thousands of deaths each year in developing countries.

Institute Executive Director Professor Mark von Itzstein said research findings published in the world-leading Chemical Biology journal Nature Chemical Biology this week demanded a total rethink of how these viruses work.

"Rotaviruses are thought to infect the bodies by sticking to certain types of sugars called sialic acids on the surface of our stomach cells. They then enter cells and reproduce rapidly, causing illness," he said.

"Rotavirus vaccines are still in their infancy, as problems emerged with the first vaccine that was trialled a number of years ago. While other vaccines are now in clinical use, new directions are required in the development of potential drugs to prevent or treat this deadly virus."

He said that to better understand how carbohydrates are involved in rotavirus infection, researchers had focussed on treating mammalian cells with a protein called sialidase which cuts these surface sugars so the virus cannot attach.

Previous to his group's work most scientists believed only some of the many strains of rotavirus infection could be prevented with sialidase treatment while others were apparently immune to its effects.

This led to the conclusion that some viruses depend on sialic acid to infect the body while others were thought to cause infection independent of sialic acid.

"Unsuccessful attempts to reduce rotavirus infection with this treatment led scientists to group rotaviruses into two class
'/>"/>

Contact: Jeannette Langan
j.langan@griffith.edu.au
61-755-528-654
Research Australia
Source:Eurekalert

Page: 1 2

Related biology news :

1. Biomedical researchers create artificial human bone marrow in a test tube
2. Princeton researchers discover new type of laser
3. UT Southwestern researchers identify gene linked to inherited form of fatal lung disease
4. James Thomson receives 2008 Massry Prize honoring stem cell researchers
5. Researchers push nature beyond its limits to create higher-density biofuels
6. Researchers advance knowledge of little nano-machines in our body
7. No quick or easy technological fix for climate change, researchers say
8. Researchers find natures shut-off switch for cellulose production
9. Researchers compile molecular manual for 100s of inherited diseases
10. Pitt researchers create non-toxic clean-up method for potentially toxic nano materials
11. Researchers identify new anti-tumor gene
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... MUNICH , January 22, 2015 ... its tenth year  The European Patent Office to present ... Two British nominations to be featured: Christofer Toumazou ... week featuring former finalists and winners of the Award   ...
(Date:1/22/2015)... has launched its new NXG series of time clocks with ... higher standard for collecting attendance and labor data and complements ... touch screen interface and seamless connection to cloud-based iSolved, the ... for the small to mid-size employer. The G2 ...
(Date:12/22/2014)... , Dec. 22, 2014 Research and Markets ... addition of the "The Global Watermarking and ... http://photos.prnewswire.com/prnh/20130307/600769 ... digital media watermarking and fingerprinting markets. Watermarking aims ...
Breaking Biology News(10 mins):Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 2Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 3Infinisource's NXG series sets new time clock standard 2The Global Watermarking and Fingerprinting Markets 2
... 2009) Scientists from the Marine Biogeochemistry and Geology ... organized and led a team of university and government ... exploration in the Beaufort Sea and determine the spatial ... Utilizing the U.S. Coast Guard Cutter Polar Sea as ...
... a single bacterial gene into yeast, researchers from Delft ... in bioethanol production from agricultural waste material: ,More ethanol, ... This week the invention was published in the scientific ... Car fuel , Bioethanol is made by ...
... disease commonly known as chronic bronchitis or emphysema, is the ... live with COPD and while researchers have yet to find ... Institute at The University of Western Ontario in London, Canada, ... the disease. Parraga is a ...
Cached Biology News:International expedition investigates climate change, alternative fuels in Arctic 2Delft breakthrough in bioethanol production from agricultural waste 2Gaining a better picture of lung disease 2
(Date:12/25/2014)... (PRWEB) December 25, 2014 The report ... by Product Type & Provider Type - Global Advancements, ... market with an in-depth analysis and forecasting of revenues. ... spread through 221 pages and in-depth TOC on “Service ...
(Date:12/24/2014)... , Dec. 24, 2014   BioLife Solutions , Inc. (NASDAQ: ... of proprietary clinical grade hypothermic storage and ... for cells and tissues  ("BioLife" or the "Company"), today ... Stockholders on May 4, 2015 (the "Annual Meeting"). ...
(Date:12/24/2014)... BOSTON, MA (PRWEB) December 23, 2014 ... series is designed to introduce cutting edge communication ... partners of platform upgrades. This webinar series demonstrates ... their quest to leverage web conferencing’s most innovative ...
(Date:12/24/2014)... Nashville Fertility Center announced that Dr. George A. ... Reproductive Medicine (ASRM), a leading professional organization committed to advancing ... role as treasurer, Dr. Hill also fills a seat on ... the mission of ASRM. , Dr. Hill has actively ...
Breaking Biology Technology:Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4BioLife Solutions Sets Date for Annual Meeting of Stockholders 2SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 2Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 3
... 2011 Cmed Technology ... it will preview its forthcoming Timaeus Guided Trial Builder ... Meeting in Chicago, IL. Guided Trial Builder will introduce ... startup of electronic trials. It expands on the Timaeus ...
... of heat, researchers have developed a method that improves ... rechargeable batteries, which could be a cheaper alternative for ... grid. To connect solar and wind energy sources ... can store large amounts of energy created at the ...
... 7, 2011 DuPont (NYSE: DD ) ... at the JPMorgan Diversified Industries Conference to expect attractive ... selective investment in attractive areas, broad-based growth, especially in ... also reaffirmed DuPont,s 2011 earnings per share (EPS) outlook ...
Cached Biology Technology:Cmed Technology to Preview New Innovations to Speed and Streamline Electronic Trials at DIA Conference 2Cmed Technology to Preview New Innovations to Speed and Streamline Electronic Trials at DIA Conference 3The heat is on for sodium-manganese oxide rechargeable batteries 2The heat is on for sodium-manganese oxide rechargeable batteries 3The heat is on for sodium-manganese oxide rechargeable batteries 4DuPont Chair & CEO: Delivering Innovative Solutions and Long-term Growth 2DuPont Chair & CEO: Delivering Innovative Solutions and Long-term Growth 3