Navigation Links
Researchers find chink in the armor of viral 'tummy bug'
Date:12/23/2008

Researchers at Griffith University's Institute for Glycomics in collaboration with colleagues at the University of Melbourne have moved a step closer to identifying a broad spectrum treatment for the dreaded 'viral tummy bug' or rotavirus.

These highly-infectious viruses are the leading cause of severe diarrhoea in young children, responsible for thousands of hospitalisations in the developed world, and hundreds of thousands of deaths each year in developing countries.

Institute Executive Director Professor Mark von Itzstein said research findings published in the world-leading Chemical Biology journal Nature Chemical Biology this week demanded a total rethink of how these viruses work.

"Rotaviruses are thought to infect the bodies by sticking to certain types of sugars called sialic acids on the surface of our stomach cells. They then enter cells and reproduce rapidly, causing illness," he said.

"Rotavirus vaccines are still in their infancy, as problems emerged with the first vaccine that was trialled a number of years ago. While other vaccines are now in clinical use, new directions are required in the development of potential drugs to prevent or treat this deadly virus."

He said that to better understand how carbohydrates are involved in rotavirus infection, researchers had focussed on treating mammalian cells with a protein called sialidase which cuts these surface sugars so the virus cannot attach.

Previous to his group's work most scientists believed only some of the many strains of rotavirus infection could be prevented with sialidase treatment while others were apparently immune to its effects.

This led to the conclusion that some viruses depend on sialic acid to infect the body while others were thought to cause infection independent of sialic acid.

"Unsuccessful attempts to reduce rotavirus infection with this treatment led scientists to group rotaviruses into two classes: 'sialidase-sensitive' and 'sialidase-insensitive' strains," he said.

The team used nuclear magnetic resonance spectroscopy, 3D modelling and cell-based assays to observe the interaction between the virus and host cells.

"We found that a human strain previously through insensitive to sialidase does in fact recognise and bind to sialic acid, but it is a sialic acid not accessible to sialidase treatment." Professor von Itzstein said.

"This reveals that there is a common chink in the armour of these rotaviruses.

"This discovery is the first step in designing a broad-spectrum drug able to exploit this weakness to combat many types of human and animal rotaviruses."


'/>"/>

Contact: Jeannette Langan
j.langan@griffith.edu.au
61-755-528-654
Research Australia
Source:Eurekalert

Related biology news :

1. Biomedical researchers create artificial human bone marrow in a test tube
2. Princeton researchers discover new type of laser
3. UT Southwestern researchers identify gene linked to inherited form of fatal lung disease
4. James Thomson receives 2008 Massry Prize honoring stem cell researchers
5. Researchers push nature beyond its limits to create higher-density biofuels
6. Researchers advance knowledge of little nano-machines in our body
7. No quick or easy technological fix for climate change, researchers say
8. Researchers find natures shut-off switch for cellulose production
9. Researchers compile molecular manual for 100s of inherited diseases
10. Pitt researchers create non-toxic clean-up method for potentially toxic nano materials
11. Researchers identify new anti-tumor gene
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/21/2016)... Unique technology combines v ... security   Xura, Inc. ... digital communications services, today announced it is working alongside ... customers, particularly those in the Financial Services Sector, the ... within a mobile app, alongside, and in combination with, ...
(Date:3/15/2016)... March 15, 2016 --> ... by Transparency Market Research "Digital Door Lock Systems Market - ... - 2023," the global digital door lock systems market in ... 2014 and is forecast to grow at a CAGR of ... small and medium enterprises (MSMEs) across the world and high ...
(Date:3/14/2016)... 2016 http://www.apimages.com ) - ... - Renvoi : image disponible via AP Images ... --> DERMALOG, le leader de ... lecteurs d,empreintes digitales pour l,enregistrement des réfugiés en ... pour produire des cartes d,identité aux réfugiés. DERMALOG ...
Breaking Biology News(10 mins):
(Date:4/27/2016)... ... April 27, 2016 , ... Global Stem Cells ... of an Asia-Pacific Symposium as other research and development initiatives for potential stem cell ... and top Global Stem Cells Group executives began meeting to establish a working agenda ...
(Date:4/27/2016)... 2016 ReportsnReports.com adds 2016 ... focus on US, EU, China ... the healthcare business intelligence collection of its growing ... report on the Flow Cytometry market spread across ... 282 tables and figures is now available at ...
(Date:4/26/2016)... ... 26, 2016 , ... BaseHealth , the comprehensive predictive ... as Chief Business Officer. Arianpour, a genomics pioneer and visionary commercial leader with ... recently Chief Commercial Officer of Pathway Genomics. He has held senior executive roles ...
(Date:4/26/2016)... ... 2016 , ... Heidelberg Instruments, a leader in design, development ... Volume Pattern Generator (VPG) line of lithography systems. The breakthrough VPG+ system is ... a solution for mid volume direct write lithography applications. It utilizes the ...
Breaking Biology Technology: