Navigation Links
Researchers find cancer-inhibiting compound under the sea
Date:8/7/2008

chers could deliver useful compounds because natural products were considered too costly and time-consuming to research and develop.

Many common medications, from pain relievers to cholesterol-reducing statins, stem from natural products that grow on the earth, but there is literally an ocean of compounds yet to be discovered in our seas. Only 14 marine natural products developed are in clinical trials today, Luesch said, and one drug recently approved in Europe is the first-ever marine-derived anticancer agent.

"Marine study is in its infancy," said William Fenical, Ph.D., a distinguished professor of oceanography and pharmaceutical sciences at the University of California, San Diego. "The ocean is a genetically distinct environment and the single, most diverse source of new molecules to be discovered."

The history of pharmacy traces its roots back thousands of years to plants growing on Earth's continents, used by ancient civilizations for medicinal purposes, Fenical added. Yet only in the past 30 years have scientists begun to explore the organisms in Earth's oceans, he said. Fewer than 30 labs exist worldwide and research dollars have only become available in the past 15 years.

HDACs are already targeted by a drug approved for cutaneous T-cell lymphoma manufactured by the global pharmaceutical company Merck & Co. Inc. However, UF's compound does not inhibit all HDACs equally, meaning a largazole-based drug might result in improved therapies and fewer side effects, Luesch said.

Since 2006, Luesch and his team of researchers have screened cyanobacteria provided by collaborator Valerie Paul, Ph.D., head scientist at the Smithsonian Marine Station in Fort Pierce. They check the samples for toxic activity against cancer cells and last year encountered one exceptionally potent extract the one that ultimately yielded largazole.

To conduct further biological testing on the compound, Luesch and his team have been
'/>"/>

Contact: Linda Homewood
homewood@ufl.edu
352-273-6873
University of Florida
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Researchers discover new strategies for antibiotic resistance
8. Researchers find new taste in fruit flies: carbonated water
9. Binghamton University researchers investigate evolving malaria resistance
10. UIC researchers find promising new targets for antibiotics
11. Researchers develop simple method to create natural drug products
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... consumption could be as good for your mental as ... conducted by the University of Warwick,s Medical School using ... by BMJ Open focused on mental wellbeing ... consistently associated with an individual,s fruit and vegetable consumption. ... five or more portions of fruit and vegetables a ...
(Date:9/23/2014)... including humans, have parasitic DNA fragments called "jumping genes" ... in the process. And that phenomenon can result in ... University of Rochester now report that the "jumping genes" ... a multi-function protein stops keeping them in check in ... a study published today in Nature Communications , ...
(Date:9/22/2014)... of cut grass in recent years has been identified ... research says the aroma also summons beneficial insects to ... the plant signals the environment via the emission of ... queue for parasitic wasps to come to the plant ... pest insect," said Dr. Michael Kolomiets, Texas A&M AgriLife ...
Breaking Biology News(10 mins):Eating five a day may keep the blues away 2A multi-function protein is key to stopping genomic parasites from 'jumping' 2Mown grass smell sends SOS for help in resisting insect attacks, researchers say 2Mown grass smell sends SOS for help in resisting insect attacks, researchers say 3
... found that infants who were fed formula enriched with ... months scored significantly better than a control group on ... three to six years. Specifically, the children ... rule-learning and inhibition between the ages of three to ...
... increased the number of fruits and vegetables eaten and ... children had two secret weapons, according to a University ... and other relatives involved because family togetherness is a ... school, target only the child, but we know that ...
... University of Colorado Cancer Center member recently published in ... that in young, female cancer survivors, quality of life ... 59 cancer survivors to 66 healthy controls and found ... anxiety than the general population. Of note, survivors reported ...
Cached Biology News:DHA-enriched formula in infancy linked to positive cognitive outcomes in childhood 2Latino families in study eat more fruits and veggies, drink less soda 2Latino families in study eat more fruits and veggies, drink less soda 3Perception of fertility affects quality of life in young, female cancer survivors 2
(Date:9/23/2014)... 23, 2014 Texas Fertility Center (TFC) ... South Austin, expanding a Central Texas footprint that includes ... The satellite office for the region’s most established practice ... the South Austin, Buda, Kyle and San Marcos communities. ... fertility treatment directly to individuals and couples living in ...
(Date:9/23/2014)... (PRWEB) September 23, 2014 The ... a developer of cellular modems , platforms ... in the Startup category for the 2014 Tekne ... held at the Minneapolis Convention Center on Thursday, ... and individuals who have shown superior technology innovation ...
(Date:9/22/2014)... CLARA, Calif. , Sept. 22, 2014 ... leading source of health information, today released the findings ... novel insights regarding physician and patient perspectives on health ... Eric Topol , a leading authority in the fields ... Editor-in-Chief of Medscape and Chief Academic Officer of Scripps ...
(Date:9/22/2014)... circulating tumor cells (CTCs) in a mouse model of ... several groups of CTCs, including significant differences from the ... generate metastases. In their study reported in the ... from the Massachusetts General Hospital (MGH) Cancer Center identified ... factors that may prove to be targets for improved ...
Breaking Biology Technology:Opening Doors to a Family: Texas Fertility Center Announces Newest Fertility Clinic in South Austin 2Opening Doors to a Family: Texas Fertility Center Announces Newest Fertility Clinic in South Austin 3NimbeLink Named Finalist for 15th Annual Tekne Awards 2NimbeLink Named Finalist for 15th Annual Tekne Awards 3WebMD/Medscape Digital Technology Survey Reveals Unique Insights Into How Patients and Physicians Perceive the Role, Potential and Risks Associated with Digital Health Technologies 2WebMD/Medscape Digital Technology Survey Reveals Unique Insights Into How Patients and Physicians Perceive the Role, Potential and Risks Associated with Digital Health Technologies 3WebMD/Medscape Digital Technology Survey Reveals Unique Insights Into How Patients and Physicians Perceive the Role, Potential and Risks Associated with Digital Health Technologies 4Massachusetts General study reveals gene expression patterns in pancreatic CTCs 2Massachusetts General study reveals gene expression patterns in pancreatic CTCs 3
... freeze budget proposal? Legislative Republicans voted for it because they ... convinced the freeze was good policy and secretly hoped Doyle ... Democrats and Gov. Jim Doyles proposal to raise the state ... vote for such a populist bill if it reaches the ...
... , ,* * * * * * * * * ... DEMOmobile 2003, and the experience has only strengthened our belief that ... The energy from the 400-plus attendees and 37 demonstrating companies was ... connectivity -- both in our homes and our businesses -- has ...
... - Representatives of the Medical College of Wisconsin, UW-Medical ... on a Milwaukee business television show, Avante's Leaders in ... on WISN. , ,Dr. Jeffrey Smith, clinical assistant professor ... School was joined by Mike Klein, founder and ...
Cached Biology Technology:Doyle and the Legislature Have Much To Agree Upon When It Comes To The Economy 2Doyle and the Legislature Have Much To Agree Upon When It Comes To The Economy 3The News From DEMOmobile 2003 2The News From DEMOmobile 2003 3The Information Age of Healthcare - Leaders featured on local new economy show 2The Information Age of Healthcare - Leaders featured on local new economy show 3
Anti-gamma Glutamyl Transferase (gammaGT) Host: mouse monoclonal Species Reactivity: human Applications: WB, IP, FC Storage: 4C...
Anti-DDDDK-Tag (Enterokinase Cleavage Site), Agarose Conjugate Research Focus: tag Storage: 4C Shipping Temperature: 4C...
Anti-ACTH Immunogen: Porcine ACTH conjugated to BSA. Available Date: 38566...
Rabbit polyclonal to SERHL ( Abpromise for all tested applications). entrezGeneID: 94009 SwissProtID: Q9H4I8...
Biology Products: